Toxicokinetics and metabolisms of benzophenone-type UV filters in rats

Toxicology

Volumn 248, Issue 2-3, 2008, Pages 89-95

  Jeon, Hee Kyung ^a   Sarma, Sailendra Nath ^a   Kim, Youn Jung ^a   Ryu, Jae Chun ^a  

^a Korea Institute of Science and Technology   (South Korea)

Author keywords

Benzophenone type UV filters; Gas chromatography mass spectrometry; Metabolism; Rats; Toxicokinetics

Indexed keywords

2,2 DIHYDROXY 4 METHOXYBENZOPHENONE; 2,3,4 TRIHYDROXYBENZOPHENONE; 4 HYDROXYBENZOPHENONE; BENZOPHENONE; BENZOPHENONE DERIVATIVE; BENZORESORCINOL; FLUMECINOL; OXYBENZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEMETHYLATION; FILTER; HYDROXYLATION; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICOKINETICS; ULTRAVIOLET RADIATION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BENZOPHENONES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; PHOTOSENSITIZING AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SUNSCREENING AGENTS; TIME FACTORS; ULTRAVIOLET RAYS;

RATTUS;

EID: 44149123304     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.02.009     Document Type: Article

References (22)

1. Bos O.J., Remijn J.P., Fischer M.J., Wilting J., and Janssen L.H. Location and characterization of warfarin binding site human serum albumin. Biochem. Pharmacol. 37 (1988) 3905-3909
2. Cosmetic Ingredient Review Panel. Final report on the safety assessment of the benzophenones-1, -3, -4, -5, -9 and -11. J. Am. Coll. Toxicol. 2 (1983) 35-77
3. EI Dareer S.M., Kalin J.R., Tillery K.F., and Hill D.L. Disposition of 2-hydroxy-4-methoxylbenzophenone in rats dosed orally, intravenously, or topically. J. Toxicol. Environ. Health 19 (1986) 491-502
4. Fluck E.R., Poirier L.A., and Ruelius H.W. Evaluation of a DNA polymerase-deficient mutant of E. coli for the rapid detection of carcinogens. Chem. Biol. Interact. 15 (1976) 219-231
5. Food and Drug Administration. Report on sunscreen drug product for over the counter human drugs. Fed. Reg. 32 (1978) 412
6. French, J.E., 1992. NTP Technical Report on Toxicity Studies of 2-Hydroxy-4-Methoxybenzophenone. National Toxicology Report No. 21, NIH Publication No. 92-3344.
7. Gabrielsson J., and Weiner D. Non-compartmental analysis. Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications (1994), Swedish Pharmaceutical Press, Stockholm p. 621
8. Jeon H.K., Chung Y., and Ryu J.C. Simultaneous determination of benzophenone-type UV filters in water and soil by gas chromatography-mass spectrometry. J. Chromatogr. A 1131 (2006) 192-202
9. Jeon H.K., Sarma S.N., Kim Y.J., and Ryu J.C. Forward gene mutation assay of seven benzophenone-type UV filters using L5178Y mouse lymphoma cell. Mol. Cell. Toxicol. 3 (2007) 23-30
10. Kadry A.M., Okereke C.S., Abdel-Rahman M.S., Friedman M.A., and Davis R.A. Pharmacokinetics of benzophenone-3 after oral exposure in male rats. J. Appl. Toxicol. 15 (1995) 97-102
11. Kaidbey K., and Grange R.W. Comparison of methods for assessing photoproection against ultraviolet A in vivo. J. Am. Acad. Dermatol. 16 (1987) 346-353
12. Lademann J., Schanzer S., Jacobi U., Schaefer H., Pflucker F., Driller H., Beck J., Meinke M., Roggan A., and Sterry W. Synergy effects between organic and inorganic UV filters in sunscreens. J. Biomed. Opt. 10 (2005) 14008
13. Mortelmans K., Haworth S., Lawlor T., Speck W., Tainer B., and Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ. Mutagen. 8 (1986) 1-119
14. Nakagawa Y., Suzuki T., and Tayama S. Metabolism and toxicity of benzophenone in isolated rat hepatocytes and estrogenic activity of its metabolites in MCF-7 cells. Toxicology 156 (2000) 27-36
15. NAS/NRC. The 1977 Survey of Industry on the Use of Food Additives. Vol. 1-3 Committee on GRAS List Survey-Phase III (1979), Food and Nutrition Board, National Research Council, National Academy of Sciences, Washington, DC
16. National Toxicity Program (NTP), 1991. NTP Technical Report on the Toxicity Studies of 2-hydroxy-4-methoxylbenzophenone in F244/N Rats and B6C3F1 Mice (Dosed Feed and Dermal Studies). NTP. Tox. 21. NTP, Research Triangle Park, NC.
17. Okereke C.S., Kadry A.M., Abdel-Rahman M.S., Davis R.A., and Friedman M.A. Metabolism of benzophenone-3 in rats. Drug Metab. Dispos. 21 (1993) 788-791
18. Sahral G.S., and Sharman B.R. Hydroxy ketones III. Fries reaction of the esters of o- and m-methoxybenzoic acid and a study of the mechanism. J. Sci. Ind. Res. (India) 16B (1957) 125-128
19. Spahn-Langguth H., and Benet L.Z. Acyl glucuronides revisited: is the clucuronidation process a toxification as well as a detoxification mechanism?. Drug Metab. Rev. 24 (1992) 5-48
20. US Food and Drug Administration Code of Federal Regulations, 1990. Title 21 CFR, Pt 177.1010. National Archives, Washington.
21. Zeiger E., Anderson B., Haworth S., Lawlor T., Mortelmans K., and Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ. Mutagen. 9 (1987) 1-109
22. Zini R., Morin D., Jouenne P., and Tillement J.P. Cicletanine binding to human plasma proteins and erythrocytes, a particular HSA-drug interaction. Life Sci. 43 (1988) 2103-2155