Effects of 18α-glycyrrhizin on the pharmacodynamics and pharmacokinetics of glibenclamide in alloxan-induced diabetic rats

European Journal of Pharmacology

Volumn 587, Issue 1-3, 2008, Pages 330-335

  Ao, Ying ^a   Chen, Jie ^b   Yue, Jiang ^a   Peng, Ren Xiu ^a  

^a WUHAN UNIVERSITY   (China)

^b WUHAN INSTITUTE OF TECHNOLOGY   (China)

Author keywords

18 glycyrrhizin; Cytochrome P 450 3A; Glibenclamide; Hypoglycemic effect; Pharmacokinetic

Indexed keywords

18ALPHA GLYCYRRHIZIN; ALANINE AMINOTRANSFERASE; ALLOXAN; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 3A; GLIBENCLAMIDE; GLYCYRRHIZIC ACID; INSULIN; ANTIDIABETIC AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DIET RESTRICTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; ENZYME ACTIVITY; EXPERIMENTAL RAT; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; LIVER INJURY; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; ANIMAL; BLOOD; DRUG INTERACTION; EXPERIMENTAL DIABETES MELLITUS; HALF LIFE TIME; INSULIN RESISTANCE; METABOLISM; WISTAR RAT;

ANIMALS; CYTOCHROME P-450 CYP3A; DIABETES MELLITUS, EXPERIMENTAL; DRUG INTERACTIONS; GLYBURIDE; GLYCYRRHIZIC ACID; HALF-LIFE; HYPOGLYCEMIC AGENTS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN RESISTANCE; LIVER GLYCOGEN; MALE; RATS; RATS, WISTAR;

EID: 44149114226     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.03.043     Document Type: Article

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