Downregulation of human colon carcinoma cell (COLO-205) proliferation through PKG-MAP kinase mediated signaling cascade by E. coli heat stable enterotoxin (STa), a potent anti-angiogenic and anti-metastatic molecule

Journal of Applied Toxicology

Volumn 28, Issue 4, 2008, Pages 475-483

  Saha, Subhrajit ^a   Chowdhury, Pinki ^a   Pal, Amit ^a   Chakrabarti, Manoj K ^a  

^a NATIONAL INSTITUTE OF CHOLERA AND ENTERIC DISEASES   (India)

Author keywords

Calcium; Heat stable enterotoxin; MAP kinase; VCAM 1; VEGF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 6 ANILINO 5,8 QUINOLINEQUINONE; CYCLIC GMP DEPENDENT PROTEIN KINASE; ESCHERICHIA COLI ENTEROTOXIN; KT 5823; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; COLON CARCINOMA; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINOQUINOLINES; ANGIOGENESIS INHIBITORS; BACTERIAL TOXINS; BLOTTING, WESTERN; CARBAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENTEROTOXINS; FLAVONOIDS; GUANYLATE CYCLASE; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM METASTASIS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MYC; TIME FACTORS; VASCULAR CELL ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

CITRUS MACROPHYLLA; ESCHERICHIA COLI;

EID: 44149087353     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1297     Document Type: Article

References (24)

1. Besson A, Davy A, Robbins SM, Yong VW. 2001. Differential activation of ERKs to focal adhesions by PKCε is required for PMA-induced adhesion and migration of human glioma cells. Oncogene 20: 7398-7401.
2. Bhattacharya J, Chakrabarti MK. 1998. Rise of intracellular free calcium levels with activation of inositol triphosphate in a human colonic carcinoma cell line (COLO 205) by heat stable enterotoxin of Escherichia coli. Biochim. Biophys. Acta 1403: 1-4.
3. Bhattacharya J, Ghosh Chaudhuri A, Sinha AK, Samanta AK, Chakrabarti MK. 1997. Binding of Escherichia coli heat-stable enterotoxin and rise of cyclic GMP in COLO 205 human colonic carcinoma cells. FEMS Microbiol. Lett. 156: 79-83.
4. Centers for Diseases Control and Prevention. 2001. Health Information for International Travel 1999-2000. Department of Health and Human Services: Atlanta.
5. Collard CD, Agah A, Reenstra W, Buras J, Stahl GL. 1999. Endothelial nuclear factor-κB translocation and vascular cell adhesion molecule-1 induction by complement inhibition with anti-human C5 therapy or cGMP analogues. Arterioscler. Thromb. Vasc. Biol. 19: 2623-2629.
6. Datta Gupta D, Saha S, Chakrabarti MK. 2005. Involvement of Protein Kinase C in the mechanism of action of Escherichia coli heat-stable enterotoxin (STa) in a human colonic carcinoma cell line, COLO-205. Toxicol. Appl. Pharmacol. 206: 9-16.
7. Ding YB, Chen GY, Xia JG, Zang XW, Yang HY, Yang L. 2003. Association of VCAM-1 overexpression with oncogenesis, tumor angiogenesis and metastasis of gastric carcinoma. World J. Gastroenterol. 9: 1409-1414.
8. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2000: 2001. Cancer Incidence, Mortality and Prevalence Worldwide. Version 1.0. International Agency For Research on Cancer: Lyon.
9. Gallant P, Shiio Y, Cheng PF, Parkhurst SM, Eisenman RN. 1996. Myc and Max homologs in Drosophila. Science 274: 1523-1527.
10. Ghiso N, Rohan RM, Amano S, Garland R, Adamis AP. 1999. Suppression of hypoxia-associated vascular endothelial growth factor gene expression by nitric oxide via cGMP. Invest. Ophthalmol. Vis. Sci. 40: 1033-1039.
11. Guarino A, Cohen M, Thompson M, Dharmsathaphorn K, Gianella RA. 1987. T84 cell receptor binding and guanylyl cyclase activation by Escherichia coli heat stable toxin. Am. J. Physiol. 253: G775-G780.
12. Gupta S, Seth A, Davis RJ. 1993. Transactivation of gene expression by cMYC is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62. Proc. Natl Acad. Sci. 90: 3216-3220.
13. Huott PA, Liu W, McRoberts JA, Gianella RA, Dharmsathaphorn K. 1988. Mechanism of action of Escherichia coli heat stable enterotoxin in a human colonic cell line. J. Clin. Invest. 82: 514-523.
14. Isono M, Haneda M, Maeda S, Omatsucamnbe M, Kikkawa R. 1998. Atrial natriuretic peptide inhibits endothelin-1-induced activation of JNK in glomerular mesangial cells. Kidney Int. 53: 1133-1132.
15. Mittelstadt PR, Salvador JM, Fornace AJ, Ashwell JD. 2005. Activating p38 MAPK: New tricks for an old kinase. Cell Cycle 4: 1189-1192.
16. Pandey KN, Nguyen HT, Li M, Boyle JW. 2000. Natriuretic peptide receptor-A negatively regulates mitogen-activated protein kinase and proliferation of mesangial cells: role of cGMP-dependent protein kinase. Biochem. Biophys. Res. Commun. 271: 374-379.
17. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH. 2001. Mitogen-activated protein kinase pathways: regulation and physiological functions. Endoc. Rev. 22: 153-183.
18. Pellizzaro C, Coradini D, Daidone MG. 2002. Modulation of angiogenesis-related proteins synthesis by sodium butyrate in colon cancer cell line HT29. Carcinogenesis 23: 735-740.
19. Pitari GM, Zingman LV, Hodgson DM, Alekseev AE, Kzerounian S, Bienengraeber M, Hajnoczky G, Terzic A, Waldman SA. 2003. Bacterial enterotoxins are associated with resistance to colon cancer. PNAS 100: 2695-2699.
20. Pouyssegur J, Volmat V, Lenormand P. 2002. Fidelity and spatiotemporal control in MAP kinase (ERKs) signaling. Biochem. Pharmacol. 64: 755-763.
21. Ray A, Chattopadhyay K, Banerjee KK, Biswas T. 2003. Macrophage distinguishes Vibrio cholerae hemolysin from its protease insensitive oligomer by time-dependent and selective expression of CD80-CD86. Immunol. Lett. 89: 143-147.
22. Sugimoto T, Kikkawa R, Haneda M, Shigela Y. 1993. Atrial natriuretic peptide inhibits endothelin-1-induced activation of mitogen activated protein kinase in culture rat mesangial cells. Biochem. Biophys. Res. Commun. 195: 72-80.
23. 44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells. Mol. Cancer Ther. 4: 51-59.
24. Visweswariah SS, Ramachandran V, Ramamohan S, Das G, Ramachandran J. 1994. Characterization and partial purification of the human receptor for the heat stable enterotoxin. Eur. J. Biochem. 219: 727-736.