Can we do better in controlling and preventing methicillin-resistant Staphylococcus aureus (MRSA) in the intensive care unit (ICU)?

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 27, Issue 6, 2008, Pages 409-413

  Humphreys, H ^a,b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b BEAUMONT HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CHLORHEXIDINE; PSEUDOMONIC ACID;

BACTERIUM IDENTIFICATION; DISEASE SURVEILLANCE; ENVIRONMENTAL SANITATION; HUMAN; INFECTION CONTROL; INFECTION PREVENTION; INTENSIVE CARE; MATHEMATICAL MODEL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; STAPHYLOCOCCUS INFECTION;

CROSS INFECTION; HANDWASHING; HUMANS; INFECTION CONTROL; INTENSIVE CARE UNITS; METHICILLIN RESISTANCE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 44149084940     PISSN: 09349723     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10096-008-0469-7     Document Type: Review

References (27)

1. Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, Carmeli Y (2003) Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: A meta-analysis. Clin Infect Dis 36:53-59
2. Shorr AF, Combes A, Kollef MH, Chastre J (2006) Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy. Crit Care Med 34:700-706
3. Chaix C, Durand-Zaleski I, Alberti C, Brun-Buisson C (1999) Control of endemic methicillin-resistant Staphylococcus aureus. A cost-benefit analysis in an intensive care unit. J Am Med Ass 282:1745-1751
4. Coia JE, Duckworth GJ, Edwards DI et al. (2006) Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities. J Hosp Infect 63S:S1-S44
5. Meyer E, Schwab F, Gastmeier P, Jonas D, Rueden H, Daschner FD (2006) Methicillin-resistant Staphylococcus aureus in German intensive care units during 2000-2003; Data from project SARI (Surveillance of antimicrobial use and antimicrobial resistance in intensive care units). Infect Control Hosp 27:146-154
6. Huang SS, Rifas-Shiman SL, Warren DK et al. (2007) Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care units. J Infect Dis 195:330-338
7. Warren DK, Guth RM, Coopersmith CM, Merz LR, Zack JE, Fraser VJ (2007) Impact of methicillin-resistant Staphylococcus aureus active surveillance program on contact precaution utilization in a surgical intensive care unit. Crit Care Med 35:430-434
8. Huang SS, Yokoe DS, Hinrichsen VL et al. (2006) Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteraemia. Clin Infect Dis 43:971-978
9. Clancy M, Graepler A, Wilson M, Douglas I, Johnson J, Price CS (2006) Active screening in high-risk units is an effective and cost-avoidant method to reduce the rate of methicillin-resistant Staphylococcus aureus infection in the hospital. Infect Control Hosp Epidemiol 27:1009-1017
10. Cepeda JA, Whitehouse T, Cooper B et al. (2005) Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: A prospective two-centre study. Lancet 365:295-304
11. Bracco D, Dubois M-J, Bouali R, Eggimann P (2007) Single rooms may help to prevent nosocomial bloodstream infection and cross-transmission of methicillin-resistant Staphylococcus aureus in intensive care-units. Intensive Care Med 33:836-840
12. Gastmeier P, Schwab F, Geffers C, Rüden H (2004). To isolate or not to isolate? Analysis of data from the German nosocomial infection surveillance system regarding the placement of patients with methicillin-resistant Staphylococcus aureus in private rooms in intensive care units. Infect Control Hosp Epidemiol 25:109-113
13. Loveday HP, Pellowe CM, Jones SRLJ, Pratt RJ (2006) A systematic review of the evidence for interventions for the prevention and control of meticillin-resistant Staphylococcus aureus (1996-2004): Report from the Joint MRSA Working Party (Subgroup A). J Hosp Infect 63S:S45-S70
14. Sandri AM, Dalarosa MG, de Alcântara LR, da Silva Elias L, Zavascki AP (2006) Reduction in incidence of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection in an intensive care unit: role of treatment with mupirocin ointment and chlorhexidine baths for nasal carriers of MRSA. Infect Control Hosp Epidemiol 27:185-187
15. Jones JC, Rogers TJ, Brookmeyer P et al (2007) Mupirocin resistance in patients colonized with methicillin-resistant Staphylococcus aureus in a surgical intensive care unit. Clin Infect Dis 45:541-547
16. Harrington G, Watson K, Bailey M et al (2007) Reduction in hospital wide incidence of infection or colonisation with methicillin-resistant Staphylococcus aureus with use of antimicrobial hand hygiene gel and statistical process control charts. Infect Control Hosp Epidemiol 28:837-844
17. Grundmann H, Hori S, Winter B, Tami A, Austin DJ (2002) Risk factors for the transmission of methicillin-resistant Staphylococcus aureus in an adult intensive care unit: Fitting a model to the data. J Infect Dis 185:481-488
18. Sexton T, Clarke P, O'Neill E, Dillane T, Humphreys H (2006) Environmental reservoirs of methicillin-resistant Staphylococcus aureus in isolation rooms: Correlation with patient isolates and implications for hospital hygiene. J Hosp Infect 62:187-194
19. Wilson AP, Hayman S, Whitehouse T et al. (2007) Importance of environment for patient acquisition of methicillin-resistant Staphylococcus aureus in the intensive care unit: A baseline study. Crit Care Med 35:2275-2279
20. Harbarth S, Masuet-Aumatell C, Schrenzel J et al. (2006) Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study. Critical Care 10:R25 (DOI 10.1186/cc3982)
21. Cunningham R, Jenks P, Northwood J, Wallis M, Ferguson S, Hunt S (2007) Effect on MRSA transmission of rapid PCR testing of patients admitted to critical care. J Hosp Infect 65:24-28
22. Rajan L, Smyth E, Humphreys H (2007) Screening for MRSA in ICU patients. How does PCR compare with culture? J Infect 55:353-357
23. Cooper BS, Medley GF, Stone SP et al. (2004) Methicillin-resistant Staphylococcus aureus in hospitals and the community: Stealth dynamics and control catastrophes. Proc Nat Acad Soc 101:10223-10228
24. McBryde ES, Pettitt AN, McElwain DLS (2007) A stochastic mathematical model of methicillin resistant Staphylococcus aureus transmission in an intensive care unit: Predicting the impact of interventions. J Theor Biol 245:470-481
25. Gould IM, MacKenzie FM, MacLennan G, Pacitti D, Watson EJ, Noble DW (2007) Topical antimicrobials in combination with admission screening and barrier precautions to control endemic methicillin-resistant Staphylococcus aureus in an Intensive Care Unit. Int J Antimicorb Ag 29:536-543
26. Pronovost P, Needham D, Berenholtz S et al. (2006) An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 355:2725-2732
27. Cooke FJ, Holmes AH (2007) The missing care bundle: Antibiotic prescribing in hospitals. Int J Antimicrob Ag 30:25-29