Characterization of the porcine KIT ligand gene: Expression analysis, genomic structure, polymorphism detection and association with coat colour traits

Animal Genetics

Volumn 39, Issue 3, 2008, Pages 217-224

  Hadjiconstantouras, C ^a,b,c   Sargent, C A ^b,c   Skinner, T M ^d   Archibald, A L ^d   Haley, C S ^d   Plastow, G S ^b,e  

^a Andreou and Costi Ltd (Pig Farms)   (Cyprus)

^b Sygen International   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Coat colour; Gene structure; KITLG; Polymorphism; Porcine

Indexed keywords

MAMMALIA; PIERIS BRASSICAE; SUIDAE; SUS;

STEM CELL FACTOR;

ALTERNATIVE RNA SPLICING; ANIMAL; ARTICLE; CHROMOSOME MAP; EXON; GENE EXPRESSION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETICS; GENOME; HAIR COLOR; INTRON; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; QUANTITATIVE TRAIT LOCUS; SWINE;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; EXONS; GENE EXPRESSION; GENOME; HAIR COLOR; INTRONS; LINKAGE (GENETICS); MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PHYSICAL CHROMOSOME MAPPING; POLYMORPHISM, GENETIC; QUANTITATIVE TRAIT LOCI; STEM CELL FACTOR; SUS SCROFA;

EID: 44049096155     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2008.01708.x     Document Type: Article

References (32)

1. Aasland M., Klungland H. & Lien S. (2000) Two polymorphisms in the bovine mast cell growth factor gene (MGF). Animal Genetics 31, 345.
2. Anderson S.I., Lopez-Corrales N.L., Gorick B. & Archibald A.L. (2000) A large-fragment porcine genomic library resource in a BAC vector. Mammalian Genome 11, 811-4.
3. Bernstein A., Forrester L., Reith A.D., Dubreuil P. & Rottapel R. (1991) The murine W/C-Kit and steel loci and the control of hematopoiesis. Seminars in Hematology 28, 138-42.
4. Brannan C.I., Lyman S.D., Williams D.E., Eisenman J., Anderson D.M., Cosman D., Bedell M.A., Jenkins N.A. & Copeland N.G. (1991) Steel-Dickie mutation encodes a c-Kit ligand lacking transmembrane and cytoplasmic domains. Proceedings of the National Academy of Sciences of the United States of America 88, 4671-4.
5. Charlier C., Denys B., Belanche J.I., Coppieters W., Grobet L., Mni M., Womack J., Hanset R. & Georges M. (1996) Microsatellite mapping of the bovine roan locus: a major determinant of White Heifer Disease. Mammalian Genome 7, 138-42.
6. Chowdhary B.P., Gustavsson I., Wikberg J.E. & Chhajlani V. (1995) Localization of the human meknocortin-5 receptor gene (MC5R) to chromosome band 18p 11.2 by fluorescence in situ hybridization. Cytogenetics and Cell Genetics 68, 79-81.
7. Day A.E., Quilter C.R., Sargent C.A. & Mileham A.J. (2002) Characterization of the porcine sperm adhesion molecule gene SPAM1 - expression analysis, genomic structure and chromosomal mapping. Animal Genetics 33, 211-4.
8. Farber C.R., Raneya N.E., Rilingtona V.D., Ventab P.J. & Ernsta C.W. (2003) Comparative mapping of genes flanking the human chromosome 12 evolutionary breakpoint in the pig. Cytogenetics and Genome Research 102, 139-44.
9. Flanagan J.G., Chan D.C. & Leder P. (1991) Transmembrane form of the Kit ligand growth factor is determined by alternative splicing and is missing in the Si(D) mutant. Cell 64, 1025-35.
10. Galli S.J., Zsebo K.M. & Geissler E.N. (1994) The kit ligand, stem cell factor. Advances in Immunology 55, 1-96.
11. Giebel L.B. & Spritz R.A. (1991) Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Proceedings of the National Academy of Sciences of the United States of America 88, 8696-9.
12. Giuffra E., Evans G., Törnsten A., Wales R., Day A., Looft H., Plastow G. & Andersson L. (1999) The Belt mutation in pigs is an allele at the dominant white (I/KIT) locus. Mammalian Genome 10, 1132-6.
13. Green P., Falls K. & Crooks S. (1990) CRI-MAP, Version 2.4. Washington University School of Medicine, St Louis, USA, Available at: http://compgen.rutgers.edu/multimap/crimap/ (accessed February 2007).
14. Haley C.S., Knott S.A. & Elsen J.M. (1994) Mapping quantitative trait loci in crosses between outbred lines using least squares. Genetics 136, 1195-207.
15. Hirooka H., de Koning D.J., van Arendonk J.A.M., Harlizius B., de Groot P.N. & Bovenhuis H. (2002) Genome scan reveals new coat color loci in exotic pig cross. The Journal of Heredity 93, 1-4.
16. Huang E.J., Nocka K.H., Buck J. & Besmer P. (1992) Differential expression and processing of two cell associated forms of the Kit-Ligand: Kl-1 andKl-2. Molecular Biology of the Cell 3, 349-62.
17. Jiang X., Gurel O., Mendiaz E.A., Stearns G.W., Clogston C.L., Lu H.S., Osslund T.D., Syed R.S., Langley K.E. & Hendrickson W.A. (2000) Structure of the active core of human stem cell factor and analysis of binding to its receptor Kit. EMBO Journal 19, 3192203.
18. Johansson Moller M., Chaudhary R., Hellmén E., Höyheim B., Chowdhary B. & Andersson L. (1996) Pigs with the dominant white coat color phenotype carry a duplication of the KIT gene encoding the mast/stem cell growth factor receptor. Mammalian Genome 7, 822-30.
19. Kijas J.M.H., Wales R., Törnsten A., Chardon P., Moller M. & Andersson L. (1998) Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. Genetics 150, 1177-85.
20. Langley K.E., Mendiaz E.A., Liu N.L. et al. (1994) Properties of variant forms of human stem-cell factor recombinantly expressed in Escherichia coli. Archives of Biochemistry and Biophysics 311, 55-61.
21. Massague J. & Pandiella A. (1993) Membrane-anchored growthfactors. Annual Review of Biochemistry 62, 515-41.
22. Motro B., Wojtowicz J.M., Bernstein A. & van der Kooy D. (1996) Steel mutant mice are deficient in hippocampal learning but not long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America 93, 1808-13.
23. Ochman H., Gerber A.S. & Haitl D.L. (1988) Genetic applications of an inverse polymerase chain reaction, Genetics 120, 621-3.
24. Okumura N., Hayashi T., Sekikawa H., Matsumoto T., Mikawa A., Hamasima N. & Awata T. (2006) Sequencing, mapping and nucleotide variation of porcine coat colour genes EDNRB, MYO5A, KITLG, SLC45A2, RAB27A, SILV and MITF. Animal Genetics 37, 80-2.
25. Rogel-Gaillard C., Bourgeaux N., Save J.C., Renard C., Coullin P., Pinton P., Yerle M., Vaiman M. & Chardon P. (1997) Construction of a swine YAC library allowing an efficient recovery of unique and centromeric repeated sequences. Mammalian Genome 8, 186-92.
26. Rohrer G.A., Alexander L.J., Hu Z., Smith T.P., Keele J.W. & Beattie C.W. (1996) A comprehensive map of the porcine genome. Genome Research 6, 371-91.
27. Seaton G., Haley C.S., Knott S.A., Kearsey M. & Visscher P.M. (2002) QTL EXPRESS: mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics 18, 339-40.
28. Seitz J.J., Schmutz S.M., Thue T.D. & Buchanan F.C. (1999) A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and Shorthorn cattle. Mammalian Genome 10, 710-2.
29. Walling G.A., Archibald A.L., Cattermole J.A., Downing A.C., Finlayson H.A., Nicholson D., Visscher P.M., Walker C.A. & Haley C.S. (1998) Mapping of quantitative trait loci on porcine chromosome 4. Animal Genatics 29, 415-24.
30. Wei W.H., de Koning D.J., Penman J.C., Finlayson H.A., Archibald A.L. & Haley C.S. (2007) QTL modulating ear size and aspect in pigs. Animal Genetics 38, 222-6.
31. Williams D.E., Devries P., Namen A.E., Widmer M.B. & Lyman S.D. (1992) The steel factor. Developmental Biology 151, 368-76.
32. Zhang Z. & Anthony R.V. (1994) Porcine stem-cell factor c-Kit ligand - its molecular-cloning and localization within the uterus. Biology of Reproduction 50, 95-102.