cAMP and cGMP in nasal mucus: Relationships to taste and smell dysfunction, gender and age

Clinical and Investigative Medicine

Volumn 31, Issue 2, 2008, Pages

  Henkin, Robert I ^a,b   Velicu, I ^a  

^a Taste and Smell Clinic   (United States)

^b Center for Molecular Nutrition and Sensory Disorders   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC GMP;

ADULT; AGE; AGED; ARTICLE; CENTRIFUGATION; COLORIMETRY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENDER; HUMAN; HYPOSMIA; MAJOR CLINICAL STUDY; MALE; NOSE MUCUS; PRIORITY JOURNAL; SEX DIFFERENCE; SMELLING DISORDER; SPECTROPHOTOMETRY; SUPERNATANT; TASTE DISORDER; ADOLESCENT; METABOLISM; MIDDLE AGED; NOSE MUCOSA; ODOR; OLFACTORY NERVE; PATHOLOGY;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CYCLIC AMP; CYCLIC GMP; FEMALE; HUMANS; MALE; MIDDLE AGED; NASAL MUCOSA; OLFACTORY NERVE; SEX FACTORS; SMELL;

EID: 44049092611     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Schaeffer LD, Sproles A, Krakowski A. Detection of cyclic AMP in parotid saliva of normal individuals. J Dent Res 1973;52:629.
2. Asakura K, Kataura A. cAMP and cGMP in the human parotid saliva. Arch Otorhinolaryngol 1980;226:145-54.
3. Glenert U, Geisler A. A simple assay for cyclic adneosine 3′,5′-monophosphate in human saliva. J Cyclic Nucleotide Protein Phosphor Res 1985;10:451-61.
4. Madsen SN, Badawi I. Variations in the content of cyclic adenosine monophosphate in human mixed saliva during physiological stimulation. Arch Oral Biol 1976;21:481-3.
5. Mornstad H, vanDijken J. Cyclic adenosine 3′,5′-monophosphate levels in human parotid saliva at different secretion rates. J Dent Res 1985;64:441-42.
6. Sproles AC. Cyclic AMP concentration in saliva of normal children and children with Downs syndrome. J Dent Res 1973;52:915-7.
7. Syrganen SM. Clinical analysis of parotid saliva and lacrimal fluid in psoriatics. Arch Dermatol Res 1983;275:152-5.
8. Kolberg H, Danielsson A, Glitterstam K, Hernriksson R, Marklund S. Studies on parotid saliva in cystic fibrosis. Acta Paediatr Scand 1982;71:321-2.
9. Kurihara K, Koyama N. High activity of adenylyl cyclase in olfactory and gustatory organs. Biochem Biophys Res Comm 1972;48:30-4.
10. Rozenzweig S, Yan W, Dasso M, Speilman AI. Possible novel mechanism for bitter taste mediated through cGMP. J Neurophysiol 1999;81:1661-5.
11. Pace U, Hanski E, Salomon Y, Lancet D. Odorant-sensitive adenylate cyclase may mediate olfactory reception. Nature 1985;316:255-8.
12. Anholt RRH. Molecular neurobiology of olfaction. Crit Rev Neurobiol 1993;7:1-22.
13. Henkin RI, Velicu I, Papathanassiu A. cAMP and cGMP in human parotid saliva: relationships to taste and smell dysfunction, gender and age. Am J Med Sci 2007;334:431-40.
14. Henkin RI, Velicu I. Biochemical basis of human sensory perception. FASEB J 2006; 20:A778.
15. Henkin RI. Taste and smell disorders, human. In: Adelman G, Smith BH, editors. Encyclopedia of Neuroscience. 3rd ed. Birkhauser, Boston; 2004.
16. Levy LM, Henkin RI, Hutter A, Lin CS, Schellinger D. Increased brain activation in response to odors in patients with hyposmia after theophylline treatment demonstrated by fMRI. J Comp Asst Tomog 1998;22:760-70.
17. Henkin RI, Velicu I. cAMP and cGMP are both present in human nasal mucus and play roles in control of olfactory function. FASEB J 2003;17:A1028
18. Henkin RI, Doherty AE, Martin BM. Nasal seroproteins: a new frontier in the exploration of physiology and pathology of nasal and sinus disease. New Frontiers. In: Veldman JE, Passali D, Lim DJ, editors. Immunobiology in Otolaryngology. Kugler: The Hague; 2000. p.127-52.
19. Henkin RI. Evaluation and treatment of human olfactory dysfunction. In: English GM, editor. Otolaryngology. Philadelphia: Lippincott; 1993. Vol.2, p.1-86.
20. Henkin RI, Schecter PJ, Friedewald WT, DeMets DL, Raff MS. A double blind study of the effects of zinc sulfate on taste and smell dysfunction. Amer J Med Sci 1976;272: 285-99.
21. R&D Systems, Minneapolis, MN. Cyclic GMP (low pH) immunoassay. Catalog number DE 0550.
22. R&D Systems, Minneapolis, MN. Cyclic AMP (low pH) immunoassay. Catalog number DE 0355.
23. Henkin RI, Lippoldt RE, Bilstad J, Edelhoch H. A zinc protein isolated from human parotid saliva. Proc Nat Acad Sci USA. 1975;72: 488-92.
24. Doty RL. Gender and endocrine-related influences on human olfactory perception. In: Meiselman R (ed) Clinical Treatments of Taste and Smell. MacMillan, NY 1986; pp. 377-413.
25. Levy, LM, Henkin, RI, Hutter, A, Lin, CS, Martins, D, Schellinger, D. Functional MRI of human olfaction. J. Comp. Asst. Tomog. 1997;21:849-56.
26. Henkin RI, Velicu I. Aberrant signaling in the olfactory system: a mechanism for smell loss. FASEB J 1994, 18:A1198.
27. Cai D, Qiu J, Cao Z, McAtee M, Bregman BS, Filben MT. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci 2001;21:4731-9.
28. Thompson WJ. Cyclic nucleotide phosphodiesterase: pharmacology, biochemistry and function. Pharmcal Ther 1991;51:13-33.
29. Firestein BL, Bredt DS. Regulation of sensory neuron precursor proliferation by cyclic GMP-dependent protein kinase. J Neurochem 1998;71:1846-53.
30. Bhatt DH, Otto SJ, Depoister B, Fetcho JR. cAMP-induced repair of zebrafish spinal circuits. Science 2004;305:254-8.
31. Pearse DD, Pereira FC, Marcillo AE, et al. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med 2004;10:610-6.
32. MacFarland RT. Molecular aspects of cyclic GMP signaling. Zool Sci 1995;12:131-63.
33. Henkin, RI, Hoetker, JD. Deficient dietary intake of Vitamin E in patients with taste and smell dysfunction: Is vitamin E a cofactor in taste bud and olfactory epithelium apoptosis and in stem cell maturation and development? Nutrition 2003;19:1013-21.
34. Velicu I, Henkin RI. On the apoptotic mechanism of action of theophylline in restoring smell function in patients with hyposmia. J Invest Med 2005;53, Subpl 2,5402.
35. Henkin, RI, Velicu I. Age related changes in saliva and nasal mucus; possible feedback mechanisms in development of gustatory and olfactory receptor function. FASEB J 2005; A1368.
36. Hinchliffe R. Aging and sensory thresholds. J Gerontol 1962;17:45-60.
37. Stevens JC, Bartoshok LM, Cam WS. Chemical senses and aging: taste versus smell. Chemical Senses 1984;9:167-79.
38. Smith CG. Age incidence of atrophy of olfactory nerves in man. J Comp Neurol 1942;77:589-95.
39. Liss L, Gomez F. The nature of senile changes of the human olfactory bulb and tract. Arch Otolaryngol 1958;67:167-71.
40. Wang J, Eslinger PJ, Smith MB, Yang QX. Functional magnetic resonance imaging study of human olfaction and normal aging. J Gerontol A Biol Sci Med Sci 2005;60:510-4.
41. Henkin RI. Taste loss in aging. In: Hsu JM, Davis RL, Neithamer. editors. The biomedical role of trace elements in aging. St. Petersburg, FL: Eckerd College Gerontology Center; 1976. p. 221-36.
42. Papathanassiu A, Henkin RI. cAMP is present in human nasal mucus and may act as a growth factor in cells of the olfactory epithelium. FASEB J 2002;16:A1153.
43. Henkin RI, Velicu I, Levy LM. Congenital smell loss - a genetic disorder of decreased cell growth and increased cell death determined by biochemical measurements in nasal mucus. FASEB J 2007;21:A806.