Identification of nonrandom patterns in structural and mutational data: The case of prion protein

Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003

Volumn , Issue , 2003, Pages 604-608

  Kuznetsov, I B ^a   Rackovsky, S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; PROTEINS; STOCHASTIC MODELS; STOCHASTIC SYSTEMS;

CELLULAR PRION PROTEINS; CONFORMATIONAL FLEXIBILITY; CONFORMATIONAL TRANSITIONS; NEURODEGENERATIVE DISORDERS; QUANTITATIVE MEASURES; STATISTICAL APPROACH; STATISTICAL SIGNIFICANCE; STRUCTURAL CONVERSION;

NEURODEGENERATIVE DISEASES;

EID: 44049089633     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/CSB.2003.1227420     Document Type: Conference Paper

References (11)

1. S.B. Prusiner, M.R. Scott, S.J. DeArmond, F.E. Cohen, "Prion protein biology.", Cell, 1998, 93, pp.337-348.
2. G.G. Kovacs, G. Trabattoni, J.A. Hainfellner, et al, "Mutations of the prion protein gene phenotypic spectrum.", J.Neurol., 2002, 249, pp.1567-1582.
3. R. Riek, G. Wider, M. Billiter, et al, "Prion protein NMR structure and familial human spongiform encephalopathies.", Proc.Natl.Acad.Sci.USA, 1998, 95, pp.11667-11672.
4. Y. Kallberg, M. Gustaffson, B. Persson, et al, "Prediction of amyloid-forming proteins.", J.Biol.Chem., 2002, 276(16), pp.12945-12950.
5. N. Jamin, Y.-M. Coic, C. Landon, et al, "Most of the structural elements of the globular domain of murine prion protein form fibrils with predominant β-sheet structure.", FEBS Lett., 2002, 529, pp.256-260.
6. L. Holm and C. Sander, "Removing near-neighbour redundancy from large protein sequence collections.", Bioinformatics, 1998, 14(5), pp.423-429.
7. U. Hobohm, M. Scharf, R. Schneider, "Selection of representative protein data sets.", Protein Sci., 1993, 1, pp.409-417.
8. M. Bulmer, "Neighboring base effects on substitution rates in pseudogenes.", Mol.Biol.Evol., 1986, 3(4), pp.322-329.
9. H. Zhang, K. Kaneko, J.T. Nguen, et al, "Conformational transitions in peptides containing two putative α-helices of the prion protein.", J.Mol.Biol., 1995, 250, pp.514-526.
10. J.H. Viles, D. Donne, G. Kroon, et al, "Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics.", Biochemistry, 2001, 40, pp.2743-2753.
11. K.J. Knaus, M. Morillas, W. Swietnicki, et al, "Crystal structure of the human prion protein reveals a mechanism for oligomerization.", Nature Struct.Biol., 2001, 8(9), pp.770-774.