Applicability of airlift draft-tube fluidized bioreactors for binary protein mixture bioseparation

Bioprocess and Biosystems Engineering

Volumn 31, Issue 4, 2008, Pages 335-344

  Dahman, Yaser ^a   Margaritis, Argyrios ^b  

^a RYERSON UNIVERSITY   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Airlift bioreactors; Bioprocess design; Bioseparation; Gas hold up; Protein adsorption

Indexed keywords

ADSORPTION; BINARY MIXTURES; HYDROPHOBICITY; MIXING; PROTEINS; SEPARATION;

AIRLIFT BIOREACTORS; BIOPROCESS DESIGN; BIOSEPARATION; PROTEIN ADSORPTION;

BIOREACTORS;

BOVINE SERUM ALBUMIN; HEMOGLOBIN;

ADSORPTION; ARTICLE; BIOREACTOR; BIOSEPARATION; COMPRESSION; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; TUBE;

ADSORPTION; AIR; BIOREACTORS; CHEMICAL FRACTIONATION; COMPLEX MIXTURES; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; MICROFLUIDICS; PROTEINS;

EID: 44049085094     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-007-0167-3     Document Type: Article

References (44)

1. Chang Y, McCreath YG, Chase H (1995) Development of an expanded bed technique for an affinity purification of G6PDH from unclarified yeast cell homogenates. Biotechnol Bioeng 48:355-366
2. Chase HA (1994) Purification of proteins by adsorption chromatography in expanded beds. Trends Biotechnol 12:296-303
3. Ahuja S (2000) Handbook of Bioseparations. Academic, California
4. Garcia M, Bonen J, Ramirez-Vick M, Sadaka A. Vuppu (1999) Bioseparation process science. Blackwell, California
5. Peterson E, Margaritis A (2001) Hydrodynamic and mass transfer characteristics of three-phase gas-lift bioreactor systems. Crit Rev Biotechnol 21(4):233-294
6. Chisti Y, Wenge F, Moo-Young M (1995) Relationship between riser and downcomer gas hold-up in internal-loop airlift reactors without gas-liquid separators. Chem Eng J 57:B7-B13
7. Chisti Y (1989) Airlift bioreactors. Elservier, New York
8. Chang Y, McCreath G, Chase H (1995) Development of an expanded bed technique for an affinity purification of G6PDH from unclarified yeast-cell homogenates. Biotechnol Bioeng 48:355-366
9. Chase H (1994) Purification of proteins by adsorption chromatography in expanded beds. Trends Biotechnol 12:296-303
10. Denizli A, Piskin E (2001) Dye-ligand affinity systems. J Biochem Bioph Meth 49:391-416
11. van Holde KE, Johnson WC, Ho PS (1998) Principles of physical biochemistry. Prentice-Hall Inc, New Jersey
12. Rapoza R, Horbett T (1990) The effects of concentration and adsorption time on the elutability of adsorbed proteins in surfactant solutions of varying structures and concentrations. J Colloid Interf Sci 136:480-492
13. Shirahama H, Susuki K, Suzawa Y (1989) Bovine hemoglobin adsorption onto polymer lattices. J Colloid Interf Sci 129:483-490
14. Kondo A, Higashitani K (1992) Adsorption of model proteins with wide variation in molecular-properties on colloid particles. J Colloid Interf Sci 150:344-351
15. Absolom D, Zingg W, Neumann A (1987) Protein adsorption to polymer particles-role of surface-properties. J Biomed Mater Res 21:161-171
16. Shirahama H, Suzawa T (1985) Adsorption of bovine serum-albumin onto styrene acrylic acid copolymer latex. Colloid Polym Sci 263:141-146
17. Yoon JY, Park HY, Kim JH, Kim WS (1996) Adsorption of BSA on highly carboxylated microspheres-quantitative effects of surface functional groups and interaction forces. J Colloid Interf Sci 177:613-620
18. Yoon JY, Park HY, Kim JH, Kim WS (1998) Interpretation of protein adsorption phenomena onto functional microspheres. Colloid Surf B 12:15-21
19. Revilla J, El-Aissari A, Carriere P, Pichot C (1996) Adsorption of bovine serum albumin onto polystyrene latex particles bearing saccharidic moieties. J Colloid Interf Sci 180:405-412
20. Grainger DW, Okano T, Kim S (1989) Protein adsorption from buffer and plasma onto hydrophilic hydrophobic poly(ethylene oxide) polystyrene multiblock copolymers. J Colloid Interf Sci 132:161-175
21. Causserand C, Kara Y, Aimar P (2001) Protein fractionation using selective adsorption on clay surface before filtration. J Memb Sci 186:165-181
22. Yoon JY, Kim JH, Kim WS (1999) The relationship of interaction forces in the protein adsorption onto polymeric microspheres. Colloid Surf A 153:413-419
23. Absolom DR, Zingg W, Neumann AW (1987) Protein adsorption to polymer particles-role of surface properties. J Biomed Mater Res 21:161-171
24. Lu X, Ding J, Wang Y, Shi J (2000) Comparison of the hydrodynamics and mass transfer characteristics of a modified square airlift reactor with common airlift reactors. Chem Eng Sci 2257-2263
25. Koide K, Iwamoto S, Takasaka Y, Matsuura S, Takarashi E, Kimura M, Kubota EJ (1984) Liquid circulation, gas holdup and pressure drop in bubble column with draught tube. J Chem Eng Jpn 17:611-618
26. Koide K, Kimura M, Nitta H, Kawabata H (1988) Liquid circulation in bubble column with draught tube. J Chem Eng Jpn 21(4):393-399
27. Weiland PG (1984) Ger Chem Eng 7:374-385 (Journal in Germany)
28. Moses V, Cape R (1999) Biotechnology the science and the business. Harwood Academic Publishers, Switzerland
29. Choi KH, Chisti Y, Moo-Young M (1996) Comparative evaluation of hydrodynamic and gas-liquid mass transfer characteristics in bubble column and airlift slurry reactors. Chem Eng J 62:223-229
30. Chisti Y, Moo-Young M (1988) Airlift reactors: characteristics, applications and design considerations. J Chem Technol Biotech 42:211-227
31. Chisti Y, Halard B, Moo-Young M (1988) Gas holdup behavior in fermentation broths and other non-Newtonian fluids in pneumatically agitated reactors. Chem Eng Sci 43:451-467
32. Chisti Y, Wenge F, Moo-Young M (1995) Relationship between riser and downcomer gas hold-up in internal-loop airlift reactors without gas-liquid separators. Chem Eng J 57:B7-B13
33. Moses V, Cape R (1999) Biotechnology: the science and the business. Harwood Academic Publishers, Switzerland
34. Choi KH, Chisti Y, Moo-Young M (1996) Comparative evaluation of hydrodynamic and gas-liquid mass transfer characteristics in bubble column and airlift slurry reactors. Chem Eng J 62:223-229
35. Kawase Y, Moo-Young M (1986) Influence of non-Newtonian flow behavior on mass transfer in bubble columns with and without draft tubes. Chem Eng Com 40:67-83
36. Lu X, Ding J, Wang Y, Shi J (2000) Comparison of the hydrodynamics and mass transfer characteristics of a modified square airlift reactor with common airlift reactors. Chem Eng Sci 2257-2263
37. Koide K, Iwamoto S, Takasaka Y, Matsuura S, Takarashi E, Kimura M, Kubota EJ (1984) Liquid circulation, gas holdup and pressure drop in bubble column with draught tube. J Chem Eng Jpn 17:611-618
38. Hills JH (1976) The operation of a bubble column at high throughputs I. Gas holdup measurements. Chem Eng J 12(2):89-112
39. Chisti Y, Moo-Young M (1993) Improve the performance of airlift bioreactors. Chem Eng Prog 89(6):38-45
40. Nakanoh M, Yoshida F (1980) Gas absorption by Newtonian and non-Newtonian liquids in a bubble column. Ind Eng Chem Proc Des Dev 19:190-195
41. Moo-Young M, Hallard B, Allen DG, Burrel R, Kawase Y (1987) Oxygen transfer to mycelial fermentation broths in an airlift fermentor. Biotechnol Bioeng 30:746-753
42. Moo-Young M, Chisti Y (1989) On the calculation of shear rate and apparent viscosity in airlift and bubble column bioreactors. Biotechnol Bioeng 34:1391-1392
43. Kondo A, Fukuda H (1998) Effects of adsorption conditions on kinetics of protein adsorption and conformational changes at ultrafine silica particles. J Colloid Interf Sci 198:34-41
44. Dahman Y, Puskas J, Margaritis A, Cunningham M (2004) Novel thymine-functionalized polystyrenes for applications in biotechnology. Adsorption of model proteins. Biomacrol 5:1412-1421