HFE mutations in nonalcoholic fatty liver disease

Hepatology

Volumn 47, Issue 5, 2008, Pages 1794-1795

  Valenti, Luca ^a   Dongiovanni, Paola ^a   Fracanzani, Anna Ludovica ^a   Fargion, Silvia ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE P1; TUMOR NECROSIS FACTOR ALPHA; HUMAN HEMOCHROMATOSIS PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

BODY MASS; C282Y GENE; CHOLESTEROL METABOLISM; COMPARATIVE STUDY; DIET; DISEASE PREDISPOSITION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GENE; GENE MUTATION; GLUCOSE METABOLISM; HEMOCHROMATOSIS; HUMAN; INSULIN RESISTANCE; IRON METABOLISM; IRON OVERLOAD; IRON STORAGE; LETTER; LIPID METABOLISM; LIVER BIOPSY; NONALCOHOLIC FATTY LIVER; OBESITY; PREVALENCE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; FIBROSIS; GENOTYPE; HETEROZYGOTE; HYPERFERRITINEMIA; IRON DEPLETION; NORTH AMERICA; OXIDATIVE STRESS; STEATOSIS;

EUROPEAN CONTINENTAL ANCESTRY GROUP; FATTY LIVER; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LIVER CIRRHOSIS; MALE; MEMBRANE PROTEINS; MUTATION;

EID: 43949134238     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22059     Document Type: Letter

References (8)

1. Nelson JE, Bhattacharya R, Lindor KD, Chalasani N, Raaka S, Heathcote EJ, et al. HFE C282Y mutations are associated wirh advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis. HEPATOLOGY 2007;46:723-729.
2. Valenti L, Fracanzani AL, Dongiovanni P, Bugianesi E, Marchesini G, Manzini P, et al. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol 2007;102:1251-1258.
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4. Beutler E, Felitti V, Gelbart T, Ho N. The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic. Ann Intern Med 2000;133:329-337.
5. Valenti L, Dongiovanni P, Fracanzani AL, Santorelli G, Fatta E, Bertelli C, et al. Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis. Dig Liver Dis 2003;35:172-178.
6. Hevi S, Chuck SL. Ferritins can regulate the secretion of apolipoprotein B. J Biol Chem 2003;278:31924-31929.
7. Valenti L, Pulixi E, Arosio P, Cremonesi L, Biasiotto G, Dongiovanni P, et al. Relative contribution of iron genes, dysmetabolism and HCV in the pathogenesis of altered iron regulation in HCV chronic hepatitis. Haematologica 2007;92:1037-1042.
8. Valenti L, Dongiovanni P, Piperno A, Fracanzani AL, Maggioni M, Rametta R, et al. alpha1-Antitrypsin mutations in NAFLD: High prevalence and association with altered iron metabolism but not with liver damage. HEPATOLOGY 2006;44:857-864.