Automated registration of tail bleeding in rats

Thrombosis and Haemostasis

Volumn 99, Issue 5, 2008, Pages 956-962

  Johansen, Peter B ^a   Henriksen, Lars ^b   Andresen, Per R ^c   Lauritzen, Brian ^a   Jensen, Kåre L ^b   Juhl, Trine N ^a   Tranholm, Mikael ^a  

^a NOVO NORDISK A S   (Denmark)

^b Videometer A/S   (Denmark)

^c NNE Pharmaplan   (Denmark)

Author keywords

Animal model; Bleeding time; Instrumentation; Rats; Tail transection

Indexed keywords

HEPARIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; AUTOMATION; BLEEDING TIME; BLOOD FLOW; CAMERA; COMPUTER PROGRAM; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; IMAGE DISPLAY; IMAGE PROCESSING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TAIL;

ANIMALS; ANTICOAGULANTS; AUTOMATION; BLEEDING TIME; BLOOD COAGULATION; EQUIPMENT DESIGN; FEMALE; HEMORRHAGE; HEPARIN; INJECTIONS, INTRAVENOUS; MODELS, ANIMAL; OBSERVER VARIATION; RATS; REPRODUCIBILITY OF RESULTS; SIGNAL PROCESSING, COMPUTER-ASSISTED; SOFTWARE; TAIL; VISUAL PERCEPTION;

EID: 43949116907     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH07-12-0738     Document Type: Article

References (8)

1. Tranholm M, Kristensen K, Kristensen AT, et al. Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A. Blood 2003; 102: 3615-3620.
2. Dejana E, Callioni A, Quintana A, et al. Bleeding time in laboratory animals. II - A comparison of different assay conditions in rats. Thromb Res 1979; 15: 191-197.
3. Stella L, Donati MB, de Gaetano G. Bleeding time in laboratory animals I. Aspirin does not prolong bleeding time in rats. Thromb Res 1975; 7: 709-716.
4. Lavelle SM, MacIomhair M. Bleeding times and the antithrombotic effects of high-dose aspirin, hirudin and heparins in the rat. Ir J Med Sci 1998; 167: 216-220.
5. Pawlinski R, Pedersen B, Erlich J, et al. Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: lessons from low tissue factor mice. Thromb Haemost 2004; 92: 444-450.
6. Dejana E, Villa S, de Gaetano G. Bleeding time in rats: a comparison of different experimental conditions. Thromb Haemost 1982; 48: 108-111.
7. Elg M, Carlsson S, Gustafsson D. Effects of agents, used to treat bleeding disorders, on bleeding time prolonged by a very high dose of a direct thrombin inhibitor in anesthesized rats and rabbits. Thromb Res 2001; 101: 159-170.
8. Tamai Y, Takami H, Nakahata R, et al. Development and practical use of the new quantitative bleeding time test apparatus. Thromb Haemost 1998; 80: 181-185.