Ischemic postconditioning's benefit on reperfusion ventricular arrhythmias is maintained in the senescent heart

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 13, Issue 2, 2008, Pages 141-148

  Dow, Joan ^a   Bhandari, Anil ^a,b   Kloner, Robert A ^a,b  

^a GOOD SAMARITAN HOSPITAL   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Ischemia reperfusion; Myocardial infarction; Postconditioning; Ventricular arrhythmias; Ventricular tachycardia

Indexed keywords

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; BLOOD PRESSURE; CONDITIONING; CONTROLLED STUDY; ELECTROCARDIOGRAM; FEMALE; HEART INFARCTION; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART RATE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE TACHYCARDIA; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; RAT; SENESCENCE;

AGING; ANIMALS; ARRHYTHMIAS, CARDIAC; FEMALE; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RATS; RATS, INBRED F344;

EID: 43949084711     PISSN: 10742484     EISSN: None     Source Type: Journal    
DOI: 10.1177/1074248408317705     Document Type: Article

References (15)

1. Murry CE, Jennings RB, Reimer KA Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 ; 74: 1124-1136.
2. Hagar JM, Hale SL, Kloner RA Effect of preconditioning ischemia on reperfusion arrhythmias after coronary artery occlusion and reperfusion in the rat. Circ Res. 1991 ; 68: 61-68.
3. Abete P., Ferrara N., Cioppa A., et al. Preconditioning does not prevent ischemic postischemic dysfunction in aging heart. J Am Coll Cardiol. 1996 ; 27: 1777-1786.
4. Abete P., Calabrese C., Ferrara N., et al. Exercise training restores ischemic preconditioning in the aging heart. J Am Coll Cardiol. 2000 ; 36: 643-650.
5. Abete P., Ferrara N., Cacciatre F., et al. High level of physical activity preserves the cardioprotective effect of pre-infarction angina in elderly patients. J Am Coll Cardiol. 2001 ; 38: 1357-1365.
6. Zhao Z. -Q, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2003 ; 285: H579 - H588.
7. Boengler R., Buechert A., Heinen Y., et al. Cardioprotection by ischemic postconditioning is lost in aged and STAT 3-deficient mice. Circ Res. 2008 ; 102: 131-135.
8. Kloner RA, Dow J., Bhandari A. Postconditioning markedly attenuates ventricular arrhythmia following ischemia/reperfusion. J Cardiovasc Pharmacol Ther. 2006 ; 11: 55-63.
9. Li Y., Whittaker P., Kloner RA The transient nature of the effects of ischemic preconditioning on myocardial infarct size and ventricular arrhythmia. Am Heart J. 1992 ; 123: 346-353.
10. Kloner RA, Rezkalla SH Preconditioning, postconditioning and their application to clinical cardiology. Cardiovasc Res. 2006 ; 70: 297-307.
11. Kloner RA, Przyklenk K., Shook T., Cannon CP Protection conferred by preinfarct angina is manifest in the aged heart: evidence from the TIMI 4 Trial. J Thromb Thrombolysis. 1998 ; 6: 89-92.
12. Przyklenk K., Li G., Simkhovich BZ, Kloner RA Mechanisms of myocardial ischemic preconditioning are age-related: protein kinase C-ε does not play a requisite role in old rabbits. J Appl Physiol. 2003 ; 95: 2563-2569.
13. Schwartz LM, Lagranha CJ Ischemic postconditioning during reperfusion activates AKt and ERK without protecting against lethal myocardial ischemia-reperfusion injury in pigs. Am J Physiol Heart Circ Physiol. 2006 ; 290: H1011 - H1018.
14. Dow J., Kloner RA Postconditioning does not reduce myocardial infarct size in an in-vivo regional ischemia rodent model. J Cardiovasc Pharmacol Ther. 2007 ; 12: 153-163.
15. Staat P., Rioufol G., Piot C., et al. Postconditioning the human heart. Circulation. 2005 ; 112: 2143-2148.