Pertussis outbreak on a neonatal unit: identification of a healthcare worker as the likely source

Journal of Hospital Infection

Volumn 69, Issue 2, 2008, Pages 131-134

  Alexander, E M ^a   Travis, S ^b   Booms, C ^b   Kaiser, A ^b   Fry, N K ^c   Harrison, T G ^c   Ganpot, B ^a   Klein, J L ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b EVELINA LONDON CHILDREN S HOSPITAL   (United Kingdom)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Neonatal unit; Pertussis; Polymerase chain reaction; Vaccination

Indexed keywords

ANTIBIOTIC AGENT; CLARITHROMYCIN; PERTUSSIS VACCINE;

ARTICLE; BACTERIUM CULTURE; BORDETELLA PERTUSSIS; CASE REPORT; COUGHING; EPIDEMIC; FEMALE; HEALTH CARE PERSONNEL; HOSPITAL INFECTION; HUMAN; INFANT; INFECTION CONTROL; INFECTION RISK; MALE; NEWBORN DISEASE; NEWBORN INTENSIVE CARE; PERTUSSIS; POLYMERASE CHAIN REACTION; SERODIAGNOSIS; UNITED KINGDOM; VACCINATION;

ADULT; BORDETELLA PERTUSSIS; CHEMOPREVENTION; CROSS INFECTION; DISEASE OUTBREAKS; DISEASE TRANSMISSION, PROFESSIONAL-TO-PATIENT; GREAT BRITAIN; HOSPITALS; HUMANS; INFANT; INFANT, NEWBORN; POLYMERASE CHAIN REACTION; SEROLOGIC TESTS; WHOOPING COUGH;

EID: 43949083002     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhin.2008.02.011     Document Type: Article

References (14)

1. Anonymous. Whooping cough: enhanced laboratory surveillance of pertussis, England and Wales 2002. CDR Wkly 13 13 (2003) 6-8
2. Anonymous. Laboratory confirmed cases of pertussis infection: data to the end of September 2005. CDR Wkly 15 51 (2005) 4-7
3. Forsyth K.D., Campins-Marti M., Caro J., et al., for the Global Pertussis Initiative. New pertussis vaccination strategies beyond infancy: recommendations by the Global Pertussis Initiative. Clin Infect Dis 39 (2004) 1802-1809
4. Crowcroft N.S., Booy R., Harrison T., et al. Severe and unrecognized pertussis in UK infants. Arch Dis Child 88 (2003) 802-806
5. Cherry J.D. Epidemiological, clinical, and laboratory aspects of pertussis in adults. Clin Infect Dis 28 Suppl. 2 (1999) S112-S117
6. Harnden A., Grant C., Harrison T., et al. Whooping cough in school age children with persistent cough: prospective cohort study in primary care. Br Med J 333 (2006) 174-177
7. Schouls L.M., van der Heide H.G., Vauterin L., Vauterin P., and Mooi F.R. Multiple-locus variable-number tandem repeat analysis of Dutch Bordetella pertussis strains reveals rapid genetic changes with clonal expansion during the late 1990s. J Bacteriol 186 (2004) 5496-5505
8. Fry N.K., Tzivra O., Duncan J., Doshi N., and Harrison T.G. Consensus real-time PCR assay for Bordetella pertussis including an internal process control provides specific diagnosis rapid turnaround time, high diagnostic yield and enhanced surveillance. Clin Microbiol Infect 10 Suppl. 3 (2004) 7
9. Reischl U., Burggraf S., Lepmeier B., Linde H.-J., and Lehn N. Rapid and specific detection of Bordetella pertussis in clinical specimens by LightCycler PCR. In: Meuer S., Wittwer C., and Nakagawara K.-I. (Eds). Rapid cycle real-time PCR: methods and applications (2001), Springer-Verlag, Berlin 313-321
10. Nardone A., Pebody R.G., Maple P.A.C., Andrews N., Gay N.J., and Miller E. Sero-epidemiology of Bordetella pertussis in England and Wales. Vaccine 22 (2004) 1314-1319
11. Slack M., Schapira D., Thwaites R., et al. Acellular pertussis vaccine given by accelerated schedule: response of pre-term infants. Arch Dis Child Fetal Neonatal Ed 89 (2004) F57-F60
12. Bassinet L., Matrat M., Njamkepo E., Aberrane S., Housset B., and Guiso N. Nosocomial pertussis outbreak among adult patients and healthcare workers. Infect Control Hosp Epidemiol 25 (2004) 995-997
13. Bryant K.A., Humbaugh K., Brothers K., et al. Measures to control an outbreak of pertussis in a neonatal intermediate care nursery after exposure to a healthcare worker. Infect Control Hosp Epidemiol 27 (2006) 541-545
14. Calugar A., Ortega-Sanchez I.R., Tiwari T., Oakes L., Jahre J.A., and Murphy T.V. Nosocomial pertussis: costs of an outbreak and benefits of vaccinating healthcare workers. Clin Infect Dis 42 (2006) 981-988