Molecular cloning and characterization of Plasmodium falciparum transketolase

Molecular and Biochemical Parasitology

Volumn 160, Issue 1, 2008, Pages 32-41

  Joshi, Shweta ^a   Singh, Alok Ranjan ^a   Kumar, Ashutosh ^a   Misra, Prakash Chandra ^b   Siddiqi, Mohammad Imran ^a   Saxena, Jitendra Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b UNIVERSITY OF LUCKNOW   (India)

Author keywords

Hexamer protein; Pentose phosphate pathway; Plasmodium falciparum; Transketolase

Indexed keywords

4 HYDROXYPHENYLPYRUVATE DIOXYGENASE; FRUCTOSE 6 PHOSPHATE; GUANIDINE; HYDROXYPYRUVATE REDUCTASE; TRANSKETOLASE;

ARTICLE; CONFOCAL MICROSCOPY; CRYSTAL STRUCTURE; CYTOSOL; ENZYME ACTIVITY; ENZYME ANALYSIS; ESCHERICHIA COLI; LEISHMANIA MEXICANA; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; NUCLEUS ACCUMBENS; OXIDATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELL NUCLEUS; CIRCULAR DICHROISM; CLONING, MOLECULAR; CYTOPLASM; DNA, PROTOZOAN; FRUCTOSEPHOSPHATES; KINETICS; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, SECONDARY; PYRUVATES; RECOMBINANT PROTEINS; TRANSKETOLASE;

ESCHERICHIA COLI; LEISHMANIA MEXICANA; PLASMODIUM FALCIPARUM; SACCHAROMYCES;

EID: 43749123900     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2008.03.005     Document Type: Article

References (51)

1. Snow R.W., Guerra C.A., Noor A.M., Myint H.Y., and Hay S.I. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434 (2005) 214-217
2. World health Organization Report. 2002; http://www.who.int/infections-disease-report-2002/index.html.
3. Gardner M.J., Hall N., Fung E., et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419 (2002) 498-511
4. Barett M.P. The pentose phosphate pathway and parasitic protozoa. Parasitol Today 13 (1997) 11-16
5. Roth E.F., Raventos-Suarez C., Perkins M., and Nagel R.L. Glutathione stability and oxidative stress in Plasmodium falciparum infection in vitro: responses of normal and G6PD deficient cells. Biochem Biophys Res Commun 109 (1982) 355-360
6. Atamna H., Pescarmona G., and Ginsburg H. Hexose-monophosphate shunt activity in intact Plasmodium falciparum infected erythrocytes and in free parasites. Mol Biochem Parasitol 67 (1994) 79-89
7. Cappadoro M., Giribaldi G., Obrien E., et al. Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency. Blood 92 (1998) 2527-2534
8. Bozdech Z., and Ginsburg H. Data mining of the transcriptome of Plasmodium falciparum, the pentose phosphate pathway and ancillary processes. Malaria J 4 (2005) 17-29
9. Schenk G., Duggleby R.G., and Nixon P.F. Properties and functions of the thiamine diphosphate dependent enzyme transketolase. Int J Biochem Cell Biol 30 (1998) 1297-1318
10. Schenk G., Layfield R., Candy J.M., Duggleby R.G., and Nixon P.F. Molecular and evolutionary analysis of thiamine-diphosphate-dependent enzyme, transketolase. J Mol Evol 44 (1997) 552-572
11. Roth E., Ruprecht R., Schulman S., Vanderberg J., and Olson J. Ribose metabolism and nucleic acid synthesis in normal and glucose-6-phosphate dehydrogenase-deficient human erythrocytes infected with Plasmodium falciparum. J Clin Invest 77 (1986) 1129-1135
12. Haslam E. Shikimic acid: metabolism and metabolites (1993), John Wiley and Sons, Chichester, United Kingdom
13. McConkey G.A. Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother 43 (1999) 175-177
14. Boros L.G., Puigjaner J., Cascante M., et al. Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Res 57 (1997) 4242-4248
15. 1 phase cycle arrest in Eherlich's tumor cells through inhibition of the pentose cycle. FEBS Lett 456 (1999) 113-118
16. Trager W., and Jensen J.B. Human malaria parasites in continuous culture. Science 193 (1976) 673
17. Sambrook J., Fritsch E.E., and Maniatis T. Molecular cloning: a laboratory manual. 2nd ed. (1989), Cold Spring Harbor Laboratory Press
18. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
19. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
20. Bhatt A.N., Prakash K., Subramanya H.S., and Bhakuni V. Different folding pathways for mesophilic and thermophilic homologues of serine hydroxymethyltransferase. Biochemistry 41 (2002) 12115-12123
21. Kochetov G.A. Determination of transketolase activity via ferricyanide reduction. Methods Enzymol 89 (1982) 43-44
22. Chaubey V., Guha M., Maity P., et al. Molecular characterization and localization of Plasmodium falciparum choline kinase. Biochim Biophys Acta 7 (2006) 1760-1767 1027-38
23. Tonkin C.J., Dooren G.G., Spurck T.P., Struck N.S., Good R.T., and Handman E. Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluoresence fixation method. Mol Biochem Parasitol 137 (2004) 13-21
24. Sali A., and Blundell T.L. Comparative protein modeling by satisfaction of spatial restraints. J Mol Biol 234 (1993) 779-815
25. Insight II 2000.1 Program. San Diego, CA: Accelrys Inc.; 2001.
26. Nikkola M., Lindqvist Y., and Schneider G. Refined structure of transketolase from Sacchromyces cerevisae at 2.0 Å resolution. J Mol Biol 238 (1994) 387-404
27. Veitch N.J., Maugeri D.A., Cazzulo J.J., Lindqvist Y., and Barrett M.P. Transketolase from Leishmania mexicana has a dual subcellular localization. Biochem J 382 (2004) 759-767
28. Laskowski R.A., MacArthur M.W., Moss D.S., and Thornton J.M. PROCHECK: a program to check the stereochemical quality of protein structures. J Appl Cryst 26 (1993) 283-291
29. Johnson W.C. Analyzing protein circular dichroism spectra for accurate secondary structures. Proteins 35 (1999) 307-312
30. Hawkins C.F., Borges A., and Perham R.N. A common structural motif in thiamin pyrophosphate-binding enzymes. FEBS Lett 255 (1989) 77-82
31. Meshalkina L., Nilsson U., Wikner C., Kostikowa T., and Schneider G. Examination of the thiamin diphosphate binding site in yeast transketolase by site-directed mutagenesis. Eur J Biochem 244 (1997) 646-652
32. Abedinia M., Lafield R., Jones S.M., Nixon P.F., and Mattick J.S. Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase. Biochem Biophys Res Commun 183 (1992) 1159-1166
33. Edsall J.T., Flory P.J., Kendrew J.C., et al. A proposal of standard conventions and nomenclature for the description of polypeptide conformations. J Mol Biol 15 (1966) 399-407
34. Mazzola J.L., and Sirover M.A. Subcellular analysis of aberrant protein structure in age-related neurodegenerative disorders. J Neurosci Methods 137 (2004) 241-246
35. Saito N., Kimura M., Kuchiba A., and Itokawa Y. The relationship between blood thiamine levels and dietary thiamine content in diabetic outpatients and healthy subjects. J Nutr Sci Vitaminol 33 (1987) 431-438
36. Wang J.J.L., Martin P.R., and Singleton C.K. Aspartate 155 of human transketolases is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation. Biochim Biophys Acta 1341 (1997) 165-172
37. Nilsson U., Meshalikina L., Lindqvist Y., and Schneider G. Examination of substrate binding in thiamin diphosphate-dependent transketolase by protein crystallography and site-directed mutagenesis. J Biol Chem 272 (1997) 1864-1869
38. de la Haba G., Leder I.G., and Racker E. Crystalline transketolase from baker's yeast. Isolation and properties. J Biol Chem 214 (1955) 409-426
39. Villafranca J.J., and Axel rod B. Heptulose synthesis from non-phosphorylated aldoses and ketoses by spinach transketolase. J Biol Chem 246 (1971) 3126-3131
40. Paoletti F., and Aldinucci D. Immunoaffinity purification of rat liver transketolase: evidence for multiple forms of the enzyme. Arch Biochem Biophys 245 (1986) 212-219
41. Heinrich P.C., Steffen H., Janser P., and Wiss O. Studies on the reconstitution of apotransketolase with thiamine pyrophosphate and analogs of the coenzyme. Eur J Biochem 30 (1972) 533-541
42. Sprenger G.A., Schorken U., Sprenger G., and Sahm H. Transketolase A of E. coli. K12. Purification and properties from recombinant strains. Eur J Biochem 230 (1995) 525-532
43. Saul A., and Battistutta D. Codon usage in Plasmodium falciparum. Mol Biochem Parasitol 27 (1988) 35-42
44. Sayers J.R., Price H.P., Fallon P.G., and Doenhoff M.J. AGA/AGG codon usage in parasites: implications for gene expression in Escherichia coli. Parasitol Today 11 (1995) 345-346
45. Masri S.W., Ali M., and Gubler C.J. Isolation of transketolase from rabbit liver and comparison of some of its kinetic properties with transketolase from other sources. Comp Biochem Physiol B 90 (1988) 167-172
46. Phillipov P.P., Shestakova I.K., Tikhomirova N.K., and Kochetov G.A. Characterization and properties of pig liver transketolase. Biochim Biophys Acta 613 (1980) 359-369
47. Waltham M. Studies on dihydrofolate reductase and transketolase. PhD thesis, The University of Queensland, Brisbane, Australia; 1990.
48. Solovjeva O.N., and Kochetov G.A. Inhibition of transketolase by p-hydroxyphenylpyruvate. FEBS Lett 462 (1999) 246-248
49. Jung E.H., Takeuchi T., Nishino K., and Itakova Y. Studies on the nature of thiamine pyrophosphate binding and dependency of divalent cations of transketolase from human erythrocytes. Int J Biochem 20 (1988) 1255-1259
50. Coy J.F., Dressler D., Wilde J., and Schubert P. Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. Clin Lab 51 (2005) 257-273
51. Glinsky G.V., Ivanova Y.A., and Glinskii A.B. Common malignancy-associated regions of transcriptional activation (MARTA) in human prostrate, breast, ovarian, and colon cancers are targets for DNA amplification. Cancer Lett 201 (2003) 67-77