Troponin I and right ventricular dysfunction for risk assessment in patients with nonmassive pulmonary embolism in the Emergency Department in combination with clinically based risk score

Internal and Emergency Medicine

Volumn 3, Issue 2, 2008, Pages 131-138

  Palmieri, Vittorio ^a,b   Gallotta, Giovanni ^b   Rendina, Domenico ^c   De Bonis, Silvana ^c   Russo, Vittorio ^c   Postiglione, Alfredo ^b   Martino, Stefania ^b   Di Minno, Matteo Nicola Dario ^b   Celentano, Aldo ^a,b  

^a Unit of Cardiology Ospedale dei Pellegrini   (Italy)

^b FEDERICO II UNIVERSITY HOSPITAL   (Italy)

^c CARDARELLI HOSPITAL   (Italy)

Author keywords

Echocardiography; Prognosis; Pulmonary embolism; Troponin

Indexed keywords

TROPONIN I;

ADULT; AGED; ARTICLE; BLOOD; COMPARATIVE STUDY; ECHOCARDIOGRAPHY; FEMALE; HEALTH SURVEY; HEART RIGHT VENTRICLE FUNCTION; HEMODYNAMICS; HUMAN; LUNG EMBOLISM; MALE; MIDDLE AGED; PREVALENCE; PROGNOSIS; RISK ASSESSMENT;

ADULT; AGED; ECHOCARDIOGRAPHY; FEMALE; HEALTH STATUS INDICATORS; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; PREVALENCE; PROGNOSIS; PULMONARY EMBOLISM; RISK ASSESSMENT; TROPONIN I; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 43749120070     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-008-0134-2     Document Type: Article

References (24)

1. Guidelines on diagnosis and management of acute pulmonary embolism. Task Force on Pulmonary Embolism, European Society of Cardiology (2000) Eur Heart J 21:1301-1336
2. Piazza G, Goldhaber SZ (2006) Acute pulmonary embolism: part II: treatment and prophylaxis. Circulation 114:e42-e47
3. Becattini C, Vedovati MC, Agnelli G (2007) Prognostic value of troponins in acute pulmonary embolism: a meta-analysis. Circulation 116:427-433
4. Goldhaber SZ, Elliott CG (2003) Acute pulmonary embolism: part II: risk stratification, treatment, and prevention. Circulation 108:2834-2838
5. Goldhaber SZ, Elliott CG (2003) Acute pulmonary embolism: part I: epidemiology, pathophysiology, and diagnosis. Circulation 108:2726-2729
6. Goldhaber SZ (2004) Pulmonary embolism. Lancet 363:1295-1305
7. La Vecchia L, Ottani F, Favero L, Spadaro GL, Rubboli A, Boanno C, Mezzena G, Fontanelli A, Jaffe AS (2004) Increased cardiac troponin I on admission predicts in-hospital mortality in acute pulmonary embolism. Heart 90:633-637
8. Douketis JD, Leeuwenkamp O, Grobara P, Johnston M, Sohne M, Ten Wolde M, Buller H (2005) The incidence and prognostic significance of elevated cardiac troponins in patients with submassive pulmonary embolism. J Thromb Haemost 3:508-513
9. Kasper W, Konstantinides S, Geibel A, Tiede N, Krause T, Just H (1997) Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism. Heart 77:346-349
10. Grifoni S, Olivotto I, Cecchini P, Pieralli F, Camaiti A, Santoro G, Conti A, Agnelli G, Berni G (2000) Short-term clinical outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventricular dysfunction. Circulation 101:2817-2822
11. Kucher N, Wallmann D, Carone A, Windecker S, Meier B, Hess OM (2003) Incremental prognostic value of troponin I and echocardiography in patients with acute pulmonary embolism. Eur Heart J 24:1651-1656
12. Pruszczyk P, Bochowicz A, Torbicki A, Szulc M, Kurzyna M, Fijalkowska A, Kuch-Wocial A (2003) Cardiac troponin T monitoring identifies high-risk group of normotensive patients with acute pulmonary embolism. Chest 123:1947-1952
13. Aujesky D, Roy PM, Le Manach CP, Verschuren F, Meyer G, Obrosky DS, Stone RA, Cornuz J, Fine MJ (2006) Validation of a model to predict adverse outcomes in patients with pulmonary embolism. Eur Heart J 27:476-481
14. Aujesky D, Obrosky DS, Stone RA, Auble TE, Perrier A, Cornuz J, Roy PM, Fine MJ (2005) Derivation and validation of a prognostic model for pulmonary embolism. Am J Respir Crit Care Med 172:1041-1046
15. Aksay E, Yanturali S, Kiyan S (2007) Can elevated troponin I levels predict complicated clinical course and inhospital mortality in patients with acute pulmonary embolism? Am J Emerg Med 25:138-143
16. Wicki J, Perneger TV, Junod AF, Bounameaux H, Perrier A (2001) Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score. Arch Intern Med 161:92-97
17. Rodger M, Wells PS (2001) Diagnosis of pulmonary embolism. Thromb Res 103:V225-V238
18. McConnell MV, Solomon SD, Rayan ME, Come PC, Goldhaber SZ, Lee RT (1996) Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am J Cardiol 78:469-473
19. Raschke RA, Reilly BM, Guidry JR, Fontana JR, Srinivas S (1993) The weight-based heparin dosing nomogram compared with a "standard care" nomogram. A randomized controlled trial. Ann Intern Med 119:874-881
20. Gallotta G, Palmieri V, Piedimonte V, Rendina D, De Bonis S, Russo V, Celentano A, Di Minno MN, Postiglione A, Di Minno G (2007) Increased troponin I predicts in-hospital occurrence of hemodynamic instability in patients with sub-massive or non-massive pulmonary embolism independent to clinical, echocardiographic and laboratory information. Int J Cardiol [E-pub ahead of print March 23]
21. Logeart D, Lecuyer L, Thabut G, Tabet JY, Tartiere JM, Chavelas C, Bonnin F, Stievenart JL, Solal AC (2007) Biomarker-based strategy for screening right ventricular dysfunction in patients with non-massive pulmonary embolism. Intensive Care Med 33:286-292
22. Dawson D, Trapp RG (2004) Analyzing research questions about survival. In: Dawson D, Trapp RG (eds) Basic and cliniucal biostatistics. McGraw-Hill, New York, pp 221-241
23. Binder L, Pieske B, Olschewski M, Geibel A, Klostermann B, Reiner C, Konstantinides S (2005) N-terminal pro-brain natriuretic peptide or troponin testing followed by echocardiography for risk stratification of acute pulmonary embolism. Circulation 112:1573-1579
24. Kostrubiec M, Pruszczyk P, Bochowicz A, Pacho R, Szulc M, Kaczynska A, Styczynski G, Kuch-Wocial A, Abramczyk P, Bartoszewicz Z, Berent H, Kuczynska K (2005) Biomarker-based risk assessment model in acute pulmonary embolism. Eur Heart J 26:2166-2172