Synthesis of 5′-functionalized nucleosides: S-Adenosylhomocysteine analogues with the carbon-5′ and sulfur atoms replaced by a vinyl or halovinyl unit

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5424-5433

  Wnuk, Stanislaw F ^a   Sacasa, Pablo R ^a   Lewandowska, Elzbieta ^a   Andrei, Daniela ^a   Cai, Sumin ^b   Borchardt, Ronald T ^b  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Cross coupling; Cross metathesis; Nucleosides; S Adenosylhomocysteine hydrolase; Wittig reaction

Indexed keywords

5' DEOXY 5' (IODOMETHYLENE)NUCLEOSIDE; 5' DEOXY 5' METHYLENEADENOSINE; ADENOSINE DERIVATIVE; ADENOSYLHOMOCYSTEINASE; ALKENYL GROUP; AMINO ACID DERIVATIVE; BROMINE DERIVATIVE; FLUORINE DERIVATIVE; NUCLEOSIDE DERIVATIVE; PALLADIUM; S ADENOSYLHOMOCYSTEINE; URIDINE DERIVATIVE; VINYL DERIVATIVE; ZINC DERIVATIVE; CARBON; NUCLEOSIDE; SULFUR;

ALKYLATION; ARTICLE; CATALYST; CROSS COUPLING REACTION; DRUG SYNTHESIS; STEREOCHEMISTRY; WITTIG REACTION; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; STEREOISOMERISM; SYNTHESIS;

ADENOSYLHOMOCYSTEINASE; ALKYLATION; CARBON; CATALYSIS; HUMANS; MOLECULAR STRUCTURE; NUCLEOSIDES; PALLADIUM; S-ADENOSYLHOMOCYSTEINE; STEREOISOMERISM; SULFUR; VINYL COMPOUNDS;

EID: 43749117513     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.017     Document Type: Article

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