Are filaggrin mutations associated with hand eczema or contact allergy? - We do not know

British Journal of Dermatology

Volumn 158, Issue 6, 2008, Pages 1383-1384

  Brown, S J ^a,b   Cordell, H J ^b  

^a ROYAL VICTORIA INFIRMARY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Atopic eczema; Contact allergy; Filaggrin; Hand dermatitis

Indexed keywords

FILAGGRIN;

ATOPIC DERMATITIS; CONTACT ALLERGY; CONTACT DERMATITIS; DISEASE PREDISPOSITION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HAND ECZEMA; HEREDITY; HUMAN; LETTER; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR;

CASE-CONTROL STUDIES; DERMATITIS, CONTACT; GENETIC MARKERS; HAND DERMATOSES; HUMANS; INTERMEDIATE FILAMENT PROTEINS; PHENOTYPE;

EID: 43749085744     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2008.08551.x     Document Type: Letter

References (10)

1. Lerbaek A, Bisgaard H, Agner T et al. Filaggrin null alleles are not associated with hand eczema or contact allergy. Br J Dermatol 2007 157 : 1199 204.
2. Smith FJ, Irvine AD, Terron-Kwiatkowski A et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet 2006 38 : 337 42.
3. Balding DJ. A tutorial on statistical methods for population association studies. Nat Rev Genet 2006 7 : 781 91.
4. Cookson WO, Moffatt MF. The genetics of atopic dermatitis. Curr Opin Allergy Clin Immunol 2002 2 : 383 7.
5. Sandilands A, Terron-Kwiatkowski A, Hull PR et al. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet 2007 39 : 650 4.
6. Weidinger S, Rodriguez E, Stahl C et al. Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis. J Invest Dermatol 2007 127 : 724 6.
7. Baurecht H, Irvine AD, Novak N et al. Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data. J Allergy Clin Immunol 2007 120 : 1406 12.
8. Rystedt I. Hand eczema and long-term prognosis in atopic dermatitis. Acta Derm Venereol (Stockh) 1985 117 (Suppl. 1 59.
9. Moss C, Friedmann PS, Shuster S et al. Susceptibility and amplification of sensitivity in contact dermatitis. Clin Exp Immunol 1985 61 : 232 41.
10. Bryld LE, Hindsberger C, Kyvik KO et al. Genetic factors in nickel allergy evaluated in a population-based female twin sample. J Invest Dermatol 2004 123 : 1025 9.