Synthesis and anti-platelet evaluation of 2-benzoylaminobenzoate analogs

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5803-5814

  Hsieh, Pei Wen ^a   Chiang, Shin Zan ^a   Wu, Chin Chung ^a   Lo, Yi Ching ^a,b   Shih, Yu Tzu ^a,b   Wu, Yang Chang ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

2 Benzoylaminobenzoate analogs; Anti platelet aggregation; Cyclooxygenase; Structure activity relationships (SAR)

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 BENZOYLAMINOBENZOATE DERIVATIVE; ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; COLLAGEN; DIMETHYL SULFOXIDE; INDOMETACIN; METHYL 4 CHLORO 2 (2,6 DIFLUOROBENZAMIDO)BENZOATE; PROPYL 4 CHLORO 2 (2,6 DIFLUOROBENZAMIDO)BENZOATE; PROSTAGLANDIN SYNTHASE INHIBITOR; THROMBIN; THROMBOXANE B2;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

AMINOBENZOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43749084144     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.071     Document Type: Article

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