Does antidepressant therapy increase suicide risk in children and adolescents? - A comment;Erhöht die therapie mit antidepressiva das suizidrisiko bei kindern und jugendlichen? - Eine stellungnahme

Neuropsychiatrie

Volumn 22, Issue 1, 2008, Pages 16-22

  Aichhorn, Wolfgang ^a   Fartacek, Reinhold ^a,b   Thun Hohenstein, Leonhard ^a,c  

^a Univ Klinik für Psychiatrie I   (Austria)

^b PPMU Salzburg

^c Univ Klinik für Psychiatrie I ^*

Author keywords

Adolescents; Antidepressants; Children; Depression; SSRI; Suicidality

Indexed keywords

ANTIDEPRESSANT AGENT; FLUOXETINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; VENLAFAXINE;

COGNITIVE THERAPY; DEPRESSION; FAMILY; HUMAN; NETHERLANDS; PRESCRIPTION; PROGNOSIS; PSYCHOSOCIAL DEVELOPMENT; PSYCHOTHERAPY; RELAPSE; REMISSION; REVIEW; RISK BENEFIT ANALYSIS; SUICIDAL BEHAVIOR; UNITED KINGDOM; UNITED STATES;

ADOLESCENT; ANTIDEPRESSIVE AGENTS; AUSTRIA; CHILD; CROSS-CULTURAL COMPARISON; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER; HUMANS; RISK; SUICIDE;

EID: 43649089640     PISSN: 09486259     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (46)

1. Weinberg WA, Rutman J, Sullivan L, Penick EC, Dietz SG. Depression in Children Referred to An Educational Diagnostic Center - Diagnosis and Treatment. Journal of Pediatrics 1973; 83: 1065-1072.
2. Leitlinien der Deutschen Gesellschaft für Kinder- und Jugendpsychiatrie und -psychotherapie. http://w ww.uni-duesseldorf.de/AWMF/11/ 028-005.htm.2007.
3. Gibbons RD, Hur K, Bhaumik DK, Mann JJ. The relationship between anti-depressant prescription rates and rate of early adolescent suicide. American Journal of Psychiatry 2006; 163: 1898-1904.
4. Olfson M, Shaffer D, Marcus SC, Greenberg T. Relationship between antidepressant medication treatment and suicide in adolescents. Archives of General Psychiatry 2003; 60: 978-982.
5. Aichhorn AW, Geretsegger C. Safety and efficacy of selective serotonin reuptake inhibitors in the treatment of children and adolescents compared to adults. Neuropsychiatrie 2005; 19: 34-39.
6. European Medicines Agency, http://www.emea.europa.eu/pdfs/human/press/pr/ 20255406en.pdf 2006.
7. Emslie GJ, Rush AJ, Weinberg WA, Kowatch RA, Hughes CW, Carmody T, Rintelmann J. A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. Archives of General Psychiatry 1997; 54: 1031-1037.
8. Keller MB, Ryan ND, Strober M, Klein RG, Kutcher SP, Birmaher B, Hagino OR, Koplewicz H, Carlson GA, Clarke GN, Emslie GJ, Feinberg D, Geller B, Kusumakar V, Papatheodorou G, Sack WH, Sweeney M, Wagner DK, Weiler EB, Winters NC, Oakes R, McCafferty JP. Efficacy of paroxetine in the treatment of adolescent major depression: A randomized, controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry 2001; 40: 762-772.
9. Wagner KD, Ambrosini P, Rynn M, Wohlberg C, Yang RY, Greenbaum MS, Childress A, Donnelly C, Deas D. Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder - Two randomized controlled trials. Jama-Journal of the American Medical Association 2003; 290: 1033-1041.
10. Kung A, Wieser E, Aichhorn M, Marksteiner J, Aichhorn W. Anxiety disorders in children and adolescents. Neuropsychiatrie 2005; 19: 83-88.
11. European Medicines Agency, http://www.emea.europa.eu/pdfs/human/press/pr/ 12891805en.pdf 2005.
12. Food and Drug AdministrationPublic health advisory, Antidepressant Use in Children Adolescents and Adults, http://www.fda.gov/cder/drug/antidepressants/ default.htm 2007.
13. Brent DA, Weersing RV. Mood disorders - depressive disorders. In: Martin A, Volkmar FR (eds.), Lewis's child and adolescent psychiatry - a comprehensive textbook, 4th ed. Philadelphia: Wolters Kluwer; 2007: 503-513.
14. Ravens-Sieberer U, Wille N, Bettge S, Erhart M. Psychische Gesundheit von Kindern und Jugendlichen in Deutschland. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 50, 871-878. 2007.
15. Mccauley E, Myers K, Mitchell J, Calderon R, Schloredt K, Treder R. Depression in Young-People - Initial Presentation and Clinical Course. Journal of the American Academy of Child and Adolescent Psychiatry 1993; 32: 714-722.
16. Rao U, Ryan ND, Birmaher B, Dahl RE, Williamson DE, Kaufman J, Rao R, Nelson B. Unipolar Depression in Adolescents - Clinical Outcome in Adulthood. Journal of the American Academy of Child and Adolescent Psychiatry 1995; 34: 566-578.
17. Weissman MM, Wickramaratne P, Nomura Y, Warner V, Verdeli H, Pilowsky DJ, Grillon C, Bruder G. Families at high and low risk for depression - A 3-generation study. Archives of General Psychiatry 2005; 62: 29-36.
18. Pilowsky DJ, Wickramaratne P, Nomura Y, Weissman MM. Family discord, parental depression, and psychopathology in offspring: 20-Year follow-up. Journal of the American Academy of Child and Adolescent Psychiatry 2006; 45: 452-460.
19. Kim-Cohen J, Caspi A, Rutter M, Tomas MP, Moffitt TE. The caregiving environments provided to children by depressed mothers with or without an antisocial history. American Journal of Psychiatry 2006; 163: 1009-1018.
20. Sachs-Ericsson N, Kendall-Tackett K, Hernandez A. Childhood abuse, chronic pain, and depression in the National Comorbidity Survey. Child Abuse & Neglect 2007; 31: 531-547.
21. Brozina K, Abela JRZ. Behavioural inhibition, anxious symptoms, and depressive symptoms: A short-term prospective examination of a diathesis-stress model. Behaviour Research and Therapy 2006; 44: 1337-1346.
22. Weissman MM. Remissions in maternal depression and child psychopathology: A STAR*D-child report (vol 295, pg 1389, 2006). Jama-Journal of the American Medical Association 2006; 296: 1234.
23. Jain S, Carmody TJ, Trivedi MH, Hughes C, Bernstein IH, Morris DW, Emslie GJ, Rush J. A psychometric evaluation of the CDRS and MADRS in assessing depressive symptoms in children. Journal of the American Academy of Child and Adolescent Psychiatry 2007; 46: 1204-1212.
24. Depressive disorders. In: Fonagy P, Target M, Cottll D, Philipps J, Kurtz Z (eds.), What works for whom ? A critical review of treatments for children and adolescents. New York: The Guilford Press; 2002: 89-105.
25. Jorm AF, Allen NB, O'Donnell CP, Parslow RA, Purcell R, Morgan AJ. Effectiveness of complementary and self-help treatments for depression in children and adolescents. MJA 185, 368-372. 2006.
26. Brent DA, Holder D, Kolko D, Birmaher B, Baugher B, Roth C, Iyengar S, Johnson B. A clinical psychotherapy trial for adolescent depression comparing cognitive, family and supprotive therapy. Arch General Psychiatr 54, 877-885. 1997.
27. Lewinsohn PM, Clarke GN. Psychosocial treatments for adolescent depression. Clin Psychol Rev 19, 329-342. 1999.
28. Klerman GL, Weissman MM, Rounsaville B, Chevron E. Interpersonal Psychotherapy of depression. New York: Basic Books; 1984.
29. Moreau D, Mufson LH, Weissman MM, Klerman GL. Interpersonal psychotherapy for adolescent depression: description of modification and preliminary application. J Am Acad Child Adolesc Psychiatry 30, 642-651. 1991.
30. Weissman MM. Recent non-medication trials of interpersonal psychotherapy for depression. Int J Neuropsychopharmacol 10, 117-122. 2007.
31. Santor DA, Kusumakar V. Open trial of interpersonal therapy in adolescents with moderate or severe depression: effectiveness of novice IPT therapists. J Am Acad Child Adolesc Psychiatry 40, 236-240. 2001.
32. Watanabe N, Hunot V, Omori IM, Churchill R, Furukawa TA. Psychotherapy for depressioin among children and adolescents: a systematic review. Acta Psychiatr Scand 116, 84-95. 2007
33. Target M, Fonagy P. The effect of psychoanalysis for children: developmental considerations. J Am Acad Child Adolesc Psychiatry 33, 1134-1144. 1994.
34. Steinhausen HC. Affektive Störungen. In: Steinhausen HC (ed.), Psychische Störungen bei Kindern und Jugendlichen, 6. ed. München Jena: Urban & Fischer; 2006: 182-194.
35. Fegert JM, Koelch M. Medikamentöse Therapie der Depression bei Kindern und Jugendlichen. Praxis Kinderpsychol Psychiatr 56[3], 224-233. 2007.
36. Whittington CJ, Kendall T, Fonagy P, Cottrell D, Cotgrove A, Boddington E. Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet 2004; 363: 1341-1345.
37. March J, Silva S, Petrycki S, Curry J, Wells K, Fairbank J, Burns B, Domino M, Vitiello B, Severe J. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression - Treatment for adolescents with depression study (TADS) randomized controlled trial. Jama-Journal of the American Medical Association 2004; 292: 807-820.
38. Emslie G, Kratochvil C, Vitiello B, Silva S, Mayes T, McNulty S, Weiler E, Waslick B, Casat C, Walkup J, Pathak S, Rohde P, Posner K, March J. Treatment for Adolescents with Depression Study (TADS): Safety results. Journal of the American Academy of Child and Adolescent Psychiatry 2006; 45: 1440-1455.
39. Melvin GA, Tonge BJ, King NJ, Heyne D, Gordon MS, Klimkeit E. A comparison of cognitive-behavioral therapy, sertraline, and their combination for adolescent depression. Journal of the American Academy of Child and Adolescent Psychiatry 2006; 45: 1151-1161.
40. Klier CM, Karwautz A. Warning of the European Agency for the Evaluation of Medicinal Products (EMEA) regarding antidepressant use in children and adolescents: Comment and recommendation from a child and adolescent psychiatry perspective. Neuropsychiatrie 2006; 20: 135-136.
41. Gibbons RD, Brown CH, Hur K, Marcus SM, Bhaurnik DK, Erkens JA, Herings RMC, Mann JJ. Early evidence on the effects of regulators' suicidality warnings on SSRi prescriptions and suicide in children and adolescents. American Journal of Psychiatry 2007; 164: 1356-1363.
42. Kurian BT, Ray WA, Arbogast PG, Fuchs DC, Dudley JA, Cooper WO. Effect of regulatory warnings on antidepressant prescribing for children and adolescents. Archives of Pediatrics & Adolescent Medicine 2007; 161: 690-696.
43. Libby AM, Brent DA, Morrato EH, Orton HD, Allen R, Valuck RJ. Decline in treatment of pediatric depression after FDA advisory on risk of suicidality with SSRIs. American Journal of Psychiatry 2007; 164: 884-891.
44. Nemeroff CB, Kalali A, Keller MB, Charney DS, Lenderts SE, Cascade EF, Stephenson H, Schatzberg AF. Impact of publicity concerning pediatric suicidality data on physician practice patterns in the United States. Archives of General Psychiatry 2007; 64: 466-472.
45. Valuck RJ, Libby AM, Orton HD, Morrato EH, Allen R, Baldessarini RJ. Spillover effects on treatment of adult depression in primary care after FDA advisory on risk of pediatric suicidality with SSRIs. American Journal of Psychiatry 2007; 164: 1198-1205.
46. Bridge JA, Barbe RP, Birmaher B, Kolko DJ, Brent DA. Emergent suicidality in a clinical psychotherapy trial for adolescent depression. American Journal of Psychiatry 2005; 162: 2173-21U2.