Prognostic significance of intestinal claudins in high-risk synchronous and metachronous multiple gastric epithelial neoplasias after initial endoscopic submucosal dissection

Pathology International

Volumn 58, Issue 6, 2008, Pages 371-377

  Semba, Shuho ^a   Hasuo, Tadateru ^a   Satake, Shinya ^a   Nakayama, Fumihito ^a   Yokozaki, Hiroshi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Endoscopic submucosal dissection; Gastric cancer; Intestinal claudin; Microsatellite instability; Synchronous and metachronous gastric epithelial neoplasias

Indexed keywords

CLAUDIN; CLAUDIN 18; CLAUDIN 3; CLAUDIN 4; MUCIN;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CONTROLLED STUDY; EARLY CANCER; ENDOSCOPIC SUBMUCOSAL DISSECTION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STOMACH CANCER;

ADENOCARCINOMA; AGED; DNA, NEOPLASM; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GASTROSCOPY; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MEMBRANE PROTEINS; MICROSATELLITE INSTABILITY; NEOPLASMS, MULTIPLE PRIMARY; PHENOTYPE; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 43549127154     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2008.02238.x     Document Type: Article

References (35)

1. Correa P. International cancer epidemiology meetings. Cancer Epidemiol Biomarkers Prev 1992 1 : 245 7.
2. Nagano H, Ohyama S, Fukunaga T et al. Indications for gastrectomy after incomplete EMR for early gastric cancer. Gastric Cancer 2005 8 : 149 54.
3. Ono H, Kondo H, Gotoda T et al. Endoscopic mucosal resection for treatment of early gastric cancer. Gut 2001 48 : 225 9.
4. Nakajima T. Gastric cancer treatment guidelines in Japan. Gastric Cancer 2002 5 : 1 5.
5. Toyonaga T, Nishino E, Hirooka T et al. Intraoperative bleeding in endoscopic submucosal dissection in the stomach and strategy for prevention and treatment. Digest Endosc 2006 18 : 123 7.
6. Hamanaka H, Gotoda T. Endoscopic resection for early gastric cancer and future expectations. Digest Endosc 2005 17 : 275 85.
7. Yasui W, Yokozaki H, Shimamoto F, Tahara H, Tahara E. Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology. Pathol Int 1999 49 : 763 74.
8. Nakashima H, Honda M, Inoue H et al. Microsatellite instability in multiple gastric cancers. Int J Cancer 1995 64 : 239 42.
9. Hasuo T, Semba S, Li D et al. Assessment of microsatellite instability status for the prediction of metachronous recurrence after initial endoscopic submucosal dissection for early gastric cancer. Br J Cancer 2007 96 : 89 94.
10. Endoh Y, Tamura G, Ajioka Y, Watanabe H, Motoyama T. Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype. Am J Pathol 2000 157 : 717 22.
11. Takahashi H, Endo T, Yamashita K et al. Mucin phenotype and microsatellite instability in early multiple gastric cancers. Int J Cancer 2002 100 : 419 24.
12. Tatematsu M, Ichinose M, Miki K, Hasegawa R, Kato T, Ito N. Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry. Acta Pathol Jpn 1990 40 : 494 504.
13. Matsuda Y, Semba S, Ueda J et al. Gastric and intestinal claudin expression at the invasive front of gastric carcinoma. Cancer Sci 2007 98 : 1014 19.
14. Tsukita S, Furuse M. Pores in the wall: Claudins constitute tight junction strands containing aqueous pores. J Cell Biol 2000 149 : 13 16.
15. Anderson JM. Molecular structure of tight junctions and their role in epithelial transport. News Physiol Sci 2001 16 : 126 30.
16. Cereijido M, Valdes J, Shoshani L, Contreras RG. Role of tight junctions in establishing and maintaining cell polarity. Annu Rev Physiol 1998 60 : 161 77.
17. Niimi T, Nagashima K, Ward JM et al. Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Mol Cell Biol 2001 21 : 7380 90.
18. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma, 2nd English edn. Gastric Cancer 1998 4 : 10 24.
19. Japanese Gastric Cancer Association. Japanese Classification of Gastric Carcinoma, 13th edn. Tokyo : Kanehara, 1999.
20. Sanada Y, Oue N, Mitani Y, Yoshida K, Nakayama H, Yasui W. Down-regulation of the claudin 18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with intestinal phenotype. J Pathol 2006 208 : 633 42.
21. Reya T, Morrison SJ, Clarke MF, Weismann IL. Stem cells, cancer, and cancer stem cells. Nature 2001 414 : 105 11.
22. Swisshelm K, Macek R, Kubbies M. Role of claudins in tumorigenesis. Adv Drug Deliv Rev 2005 57 : 919 28.
23. Soini Y, Tommola S, Helin H, Martikainen P. Claudins 1, 3, 4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse subtype. Virchows Arch 2006 448 : 52 8.
24. Lee SK, Moon J, Park SW, Song SY, Chung JB, Kang JK. Loss of the tight junction protein claudin 4 correlates with histological growth-pattern and differentiation in advanced gastric adenocarcinoma. Oncol Rep 2005 13 : 193 9.
25. James R, Erler T, Kazenwadel J. Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium. J Biol Chem 1994 269 : 15 29 37.
26. Meyer BI, Gruss P. Mouse Cdx-1 expression during gastrulation. Development 1993 117 : 191 203.
27. Eda A, Osawa H, Yanaka I et al. Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J Gastroenterol 2002 37 : 94 100.
28. Satake S, Semba S, Matsuda Y et al. Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma. Pathol Int 2008 58 : 156 63.
29. Bai YQ, Miyake S, Iwai T, Yuasa Y. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2003 22 : 7942 9.
30. Dang LH, Chen F, Knock SA et al. CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45. Oncogene 2006 25 : 2264 72.
31. Chun SY, Chen F, Washburn JG et al. CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3. Oncogene 2007 26 : 4725 9.
32. Semba S, Yokozaki H, Yamamoto S, Yasui W, Tahara E. Microsatellite instability in precancerous lesions and adenocarcinomas of the stomach. Cancer 1996 77 : 1620 27.
33. Hamamoto T, Yokozaki H, Sembna S et al. Altered microsatellites in incomplete-type intestinal metaplasia adjacent to primary gastric cancers. J Clin Pathol 1997 50 : 841 6.
34. Leung WK, Kim JJ, Kim JG, Graham DY, Sepulveda AR. Microsatellite instability in gastric intestinal metaplasia in patients with and without gastric cancer. Am J Pathol 2000 156 : 537 43.
35. Wu MS, Lee CW, Shun CT et al. Clinicopathological significance of altered loci of replication errors and microsatellite instability-associated mutations in gastric cancer. Cancer Res 1999 94 : 3034 8.