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Volumn 10, Issue 5, 2008, Pages 741-744

Copper-catalyzed synthesis of enantioenriched tetraarylethanes

Author keywords

[No Author keywords available]

Indexed keywords

BROMINATED HYDROCARBON; COPPER; DRUG DERIVATIVE; ETHANE;

EID: 43549118456     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol7027543     Document Type: Article
Times cited : (18)

References (33)
  • 2
    • 33751569703 scopus 로고    scopus 로고
    • Benzylic phosphonates/halides: (a) Molander, G. A.; Elia, M. D. J. Org. Chem. 2006, 71, 9198-9202.
    • Benzylic phosphonates/halides: (a) Molander, G. A.; Elia, M. D. J. Org. Chem. 2006, 71, 9198-9202.
  • 16
    • 0141940231 scopus 로고    scopus 로고
    • Alternative methods for accessing racemic tetraarylethanes: (a) Khurana, J. M.; Chauhan, S.; Maikap. G. C. Org. Bwmol. Chem. 2003, 1, 1737-1740.
    • Alternative methods for accessing racemic tetraarylethanes: (a) Khurana, J. M.; Chauhan, S.; Maikap. G. C. Org. Bwmol. Chem. 2003, 1, 1737-1740.
  • 27
    • 58149182091 scopus 로고    scopus 로고
    • The control reaction was run using these conditions on 31 in the presence of 1 equiv of pyridine to give 32 in 21% yield
    • The control reaction was run using these conditions on 31 in the presence of 1 equiv of pyridine to give 32 in 21% yield.
  • 28
    • 58149201686 scopus 로고    scopus 로고
    • It is well-established in the literature that Cu(I) combined with Grignard reagents forms organocuprates which can then undergo substitution reactions; for reviews, see:
    • It is well-established in the literature that Cu(I) combined with Grignard reagents forms organocuprates which can then undergo substitution reactions; for reviews, see:
  • 30
    • 0000936332 scopus 로고    scopus 로고
    • Erdik, E. Tetrahedron 1984, 40, 641-657. Therefore, it is possible that the observed dimerization occurs through a cuprate intermediate that goes on to form the observed product. Ullman biaryl coupling reactions are also wcll-documented as being catalyzed by Cu(I) via either a radical or a copper insertion pathway. For recent reviews, see:
    • (b) Erdik, E. Tetrahedron 1984, 40, 641-657. Therefore, it is possible that the observed dimerization occurs through a cuprate intermediate that goes on to form the observed product. Ullman biaryl coupling reactions are also wcll-documented as being catalyzed by Cu(I) via either a radical or a copper insertion pathway. For recent reviews, see:
  • 33
    • 58149201685 scopus 로고    scopus 로고
    • 2CuMgCl.MgCN (formed from 2i-PrMgCl + CuCN) produced none of the desired product 5.
    • 2CuMgCl.MgCN" (formed from 2i-PrMgCl + CuCN) produced none of the desired product 5.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.