An occupational health study of emergency physicians in Japan: Health assessment by immune variables (CD4, CD8, CD56, and NK cell activity) at the beginning of work

Journal of Occupational Health

Volumn 50, Issue 2, 2008, Pages 136-146

  Okamoto, Hiroteru ^a   Tsunoda, Tooru ^a   Teruya, Koji ^a   Takeda, Nobuo ^a   Uemura, Takamoto ^a   Matsui, Tomoko ^a   Fukazawa, Shinji ^a   Ichikawa, Kaoru ^a   Takemae, Rieko ^a   Tsuchida, Kosuke ^a   Takashima, Yutaka ^a  

^a KYORIN UNIVERSITY   (Japan)

Author keywords

CD56; Emergency physicians (EPs); Natural killer cell (NK cell); Occupational health; Quality of emergency medical services; Shift work; Workload of chronic overwork

Indexed keywords

CD56 ANTIGEN;

ADULT; ARTICLE; BLOOD; BURNOUT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; EMERGENCY HEALTH SERVICE; FEMALE; HUMAN; IMMUNOLOGY; JAPAN; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; NATURAL KILLER CELL; OCCUPATIONAL DISEASE; PHYSICIAN; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; QUESTIONNAIRE; WORK SCHEDULE; WORKLOAD;

ADULT; ANTIGENS, CD56; BURNOUT, PROFESSIONAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EMERGENCY MEDICAL SERVICES; FEMALE; HUMANS; JAPAN; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; OCCUPATIONAL DISEASES; PHYSICIANS; QUESTIONNAIRES; WORK SCHEDULE TOLERANCE; WORKLOAD;

EID: 43549110279     PISSN: 13419145     EISSN: 13489585     Source Type: Journal    
DOI: 10.1539/joh.L6084     Document Type: Article

References (53)

1. Kishi Y, Muraoka M, Kurosawa H, Koido Y, Yamamoto Y, Yazaki S, Nagao K and Kojima T: Burnout, depression, and quality of life among Japanese emergency physicians. Jpn J Gen Hosp Psychiatry 12, 135-143 (2000) (in Japanese)
2. Okamoto H, Yamaguchi Y, Shimazaki S, Teruya K, Takeda N, Matsui T, Ichikawa K and Tsunoda T: A study on mental health of physicians belonging to the Trauma and Critical Care Center through the Japanese version of Stress Arousal Checklist (SACL). Jpn J Occup Mental Health 12, 54-60 (2004) (in Japanese).
3. Gallery ME, Whitley TW, Klonis LK, Anzinger RK and Revicki DA: A study of occupational stress and depression among emergency physicians. Ann Emerg Med 21, 58-63 (1992)
4. Lloyd S, Streiner D and Shannon S: Burnout, depression, life and job satisfaction among Canadian emergency physicians. J Emerg Med 12, 559-565 (1994)
5. Whitley TW, Allison EJ Jr, Gallery ME, Cockington RA, Gaudry P, Heyworth J and Revicki DA: Work-related stress and depression among practicing emergency physicians: an international study. Ann Emerg Med 23, 1068-1071 (1994)
6. Whitley TW, Allison EJ Jr, Gallery ME, Cockington RA, Gaudry P, Heyworth J and Revicki DA: Work-related stress and depression among physicians pursuing postgraduate training in emergency medicine: an international study. Ann Emerg Med 20, 992-996 (1991)
7. Thomas H Jr, Schwartz E and Whitehead DC: Eight-versus 12-hour shifts: implications for emergency physicians. Ann Emerg Med 23, 1096-1100 (1994)
8. Hall KN, Wakeman MA, Levy RC and Khoury J: Factors associated with career longevity in residency-trained emergency physicians. Ann Emerg Med 21, 291-297 (1992)
9. Hall KN and Wakeman MA: Residency-trained emergency physicians: their demographics, practice evolution, and attrition from emergency medicine. J Emerg Med 17, 7-15 (1999)
10. Heyworth J, Whitley TW, Allison EJ Jr and Revicki DA: Correlates of work-related stress among consultants and senior registrars in accident and emergency medicine. Arch Emerg Med 10, 271-278 (1993)
11. Keller KL and Koenig WJ: Sources of stress and satisfaction in emergency practice. J Emerg Med 7, 293-299 (1989)
12. Burbeck R, Coomber S, Robinson SM and Todd C: Occupational stress in consultants in accident and emergency medicine: a national survey of levels of stress at work. Emerg Med J 19, 234-238 (2002)
13. Whitley TW, Gallery ME, Allison EJ Jr and Revicki DA: Factors associated with stress among emergency medicine residents. Ann Emerg Med 18, 1157-1161 (1989)
14. Taylor DM, Pallant JF, Crook HD and Cameron PA: The psychological health of emergency physicians in Australasia. Emerg Med Aust 16, 21-27(2004)
15. Kobayashi F, Furui H, Akamatsu Y, Watanabe T and Horibe H: Changes in psychophysiological functions during night shift in nurses influence of changing from a full-day to a half-day work shift before night. Int Arch Occup Environ Health 69, 83-90 (1997)
16. Xu M, Miura Y, Nagao F, Muto T and Okumura K: NK cell activity and subsets of truck drivers along with related factors. Jpn J Hyg 53, 456-462 (1998) (in Japanese)
17. Yasuda A, Iwasaki K, Sasaki T, Oka T and Hisanaga N: Lower percentage of CD56+ cells associated with long working hours. Ind Health 39, 221-223 (2001)
18. Castle S, Wilkins S, Heck E, Tanzy K and Fahey J: Depression in caregivers of demented patients is associated with altered immunity: impaired proliferative capacity, increased CD8+, and a decline in lymphocytes with surface signal transduction molecules (CD38+) and a cytotoxicity marker (CD56+ CD8+). Clin Exp Immunol 101, 487-493 (1995)
19. Kawakami N, Tanigawa T, Araki S, Nakata A, Sakurai S, Yokoyama K and Morita Y: Effects of job strain on helper-inducer (CD4+CD29+) and suppressor inducer (CD4+CD45RA+) T cells in Japanese blue-collar workers. Psychother Psychosom 66, 192-198 (1997)
20. Gucht VD, Fischler B and Demanet C: Immune dysfunction associated with chronic professional stress in nurses. Psychiatry Res 85, 105-111 (1999)
21. Nakata A, Araki S, Tanigawa T, Miki A, Sakurai S, Kawakami N, Yokoyama K and Yokoyama M: Decrease of suppressor-inducer (CD4+CD45RA) T lymphocytes and increase of serum immunoglobulin G due to perceived stress in Japanese nuclear electric power plant workers. JOEM 42, 143-150 (2000)
22. Nakata A, Araki S, Tanigawa T, Fujioka Y, Kitamura F, Iso H and Shimamoto T: Association of low job control with a decrease in memory (CD4+CD45RO+) T lymphocytes in Japanese middle-aged male workers in an electric power plant. Ind Health 40, 142-148 (2002)
23. Bargellini A, Barbieri A, Rovesti S, Vivoli R, Roncaglia R and Borella P: Relation between immune variables and burnout in a sample of physicians. Occup Environ Med 57, 453-457 (2000)
24. Nakamura H, Nagase H, Yoshida M and Ogino K: Natural Killer cell activity and NK cell subsets in workers with a tendency of burnout. J Psychosom Res 46, 569-578 (1999)
25. Morikawa Y, Kitaoka-Higashiguchi K, Tanimoto C, Hayashi M, Oketani R, Miura K, Nishijo M and Nakagawa H: A cross-sectional study on the relationship of job stress with Natural Killer cell activity and Natural Killer cell subsets among health nurses. J Occup Health 47, 378-383 (2005)
26. Pross HF, Banies MG, Rubin P, Shragge P and Patterson MS: Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. IX. The quantitation of natural killer cell activity. J Clin Immunol 1, 51-63 (1981)
27. Ip SH, Rittershaus CW, Healey KW, Struzziero CC, Hoffman RA and Hansen PW: Rapid enumeration of T lymphocytes by a flow-cytometric immunofluorescence method. Clin Chem 28, 1905-1909 (1982)
28. Wada O: Occupational and life-style risk factors and prevention of "Karoshi". Occup Health Rev 14, 183-213 (2002) (in Japanese)
29. Liu Y, Tanaka H and The Fukuoka Heart Study Group: Overtime work, insufficient sleep, and risk of non-fatal acute myocardial infarction in Japanese men. Occup Environ Med 59, 447-451 (2002)
30. Araki S and Iwasaki K: Death due to overwork (Karoshi): Causation, health service, and life expectancy of Japanese males. JMAJ 48, 92-98 (2005)
31. Iwasaki K, Takahashi M and Nakata A: Health problems due to long working hours in Japan: working hours, workers' compensation (Karoshi), and preventive measures. Ind Health 44, 537-540 (2006)
32. The Japan Institute for Labour Policy and Training: Revised occupational health and safety law enacted to strengthen measures against overwork and mental health problems. The Japan Labor Flash No.51. Email Journal December 1, 2005. (online), available from 〈http://www.jil.go.jp/foreign/emm/bi/51.htm〉, (accessed 2006-03-20).
33. Ziv Y, Shohat B, Baniel J, Ventura E, Levy E and Dintsman M: The immunologic profile of anesthetists. Anesth Analg 67, 849-851 (1988)
34. Ferson M, Edwards A, Lind A, Milton GW and Hersey P: Low natural killer-cell activity and immunoglobulin levels associated with smoking in human subjects. Int J Cancer 23, 603-609 (1979)
35. Ginns LC, Ryu JH, Rogol PR, Sprince NL, Oliver LC and Larsson CJ: Natural killer cell activity in cigarette smokers and asbestos workers. Am Rev Respir Dis 131, 831-834 (1985)
36. Phillips B, Marshhall ME, Brown S and Thompson JS: Effect of smoking on human natural killer cell activity. Cancer 56, 2788-2792 (1985)
37. Tollerud DJ, Clark JW, Brown LM, Meuland CY, Mann DL, Pankiw-Trost LK, Blattner WA and Hoover RN: Association of cigarette smoking with decreased numbers of circulating natural killer cells. Am Rev Respir Dis 139, 194-198 (1989)
38. Moszczynski P, Rutowski J and Stowinski S: The effect of cigarettes smoking on the blood counts of T and NK cells in subjects with occupational exposure to organic solvents. Cent Eur J Public Health 4, 164-168 (1996)
39. Moldofsky H, Lue FA, Davidson JR and Gorczynski R: Effects of sleep deprivation on human immune functions. FASEB J 3, 1972-1977 (1989)
40. Born J, Lange T, Hansen K, Molle M and Fehm HL: Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol 158, 4454-4464 (1997)
41. Morimoto K, Takeshita T, Inoue-Sakurai C and Maruyama S: Lifestyle and mental health status are associated with natural killer cell activities. Sci Total Environ 270, 3-11 (2001)
42. Moldofsky H, Lue FA, Eisen J, Keystone E and Gorczynski RM: The relationship of interleukin-1 and immune function of sleep in humans. Psychosom Med 48, 309-318 (1986)
43. Gatti G, Del Ponte D, Cavallo R, Sartori ML, Salvadori A, Carignola R, Carandente F and Angeli A: Circadian changes in human natural killer-cell activity. Prog Clin Biol Res 227A, 399-409 (1987)
44. Wang T, Delahanty DL, Dougall AL and Baum A: Responses of natural killer cell activity to acute laboratory stressors in healthy men at different times of day. Healthy Psychol 17, 428-435 (1998)
45. Delahanty DL, Wang T, Maravich C, Forlenza M and Baum A: Time-of-day effects on response of natural killer cells to acute stress in men and women. Healthy Psychol 19, 39-45 (2000)
46. Watson RR, Moriguchi S, Jackson JC, Werner L, Wilmore JH and Freund BJ: Modification of cellular immune functions in humans by endurance exercise training during β-adrenergic blockade with atenolol or propranolol. Med Sci Sports Exerc 18, 95-100 (1986)
47. Mackinnon LT, Chick TW, van As A, Tomasi TB. In: Dotson CO, Humphrey JH, eds. Exercise physiology. Current selected research Vol.3. New York: AMS Press, 1988: 77.
48. Crist DM, Mackinnon LT, Thompson RF, Atterbom HA and Egan PA: Physical exercise increases natural killer cellular-mediated tumor cytotoxicity in elderly women. Gerontology 35, 66-71 (1989)
49. Pedersen BK, Tvede N, Christensen LD, Klarlund K, Klagbak S and Halker-Kristensen J: Natural killer cell activity in peripheral blood of highly trained and untrained persons. Int J Sports Med 10, 129-131 (1989)
50. Kusaka Y, Kondou H and Morimoto K: Healthy lifestyles are associated with higher natural killer cell activity. Prev Med 21, 602-615 (1992)
51. Levi FA, Canon C, Touitou Y, Reinberg A and Mathe G: Seasonal modulation of the circadian time structure of circulating T and Natural Killer lymphocyte subsets from healthy subjects. J Clin Invest 81, 407-413 (1988)
52. Yovel G, Shakhar K and Ben-Eliyahu S: The effects of sex, menstrual cycle, and oral contraceptives on the number and activity of natural killer cells. Gynecol Oncol 81, 254-262 (2001)
53. Souza SS, Castro FA, Mendonca HC, Palma PV, Morais FR, Ferriani RA and Voltarelli JC: Influence of menstrual cycle on NK activity. J Reprod Immunol 50, 151-159 (2001)