Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease

International Journal of Dermatology

Volumn 47, Issue 6, 2008, Pages 562-566

  Chen, Si Yuan ^a,b   Takeuchi, Satoshi ^a,b   Moroi, Yoichi ^a,b   Hayashida, Sayaka ^a,b   Kido, Makiko ^a,b   Uchi, Hiroshi ^a,b   Takahara, Masakazu ^a,b   Uenotsuchi, Takeshi ^a,b   Tu, Ya Ting ^a,b   Urabe, Kazunori ^a,b   Furue, Masutaka ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PARAFFIN; TRANSCRIPTION FACTOR SP1; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; MALIGNANT TRANSFORMATION; PAGET SKIN DISEASE; PROTEIN EXPRESSION; TUMOR CELL;

AGED; AGED, 80 AND OVER; ANUS NEOPLASMS; AXILLA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PAGET'S DISEASE, EXTRAMAMMARY; SKIN; SKIN NEOPLASMS; SP1 TRANSCRIPTION FACTOR; UROGENITAL NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 43549094004     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2008.03643.x     Document Type: Article

References (32)

1. Folkman J. Angiogenesis and angiogenesis inhibition: An overview. EXS 1997; 79: 1-8.
2. Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983; 219: 983-985.
3. Leung DW, Cachianes G, Kuang WJ, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306-1309.
4. Tischer E, Mitchell R, Hartman T, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991; 266: 11947-11954.
5. Ema M, Taya S, Yokotani N, et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997; 94: 4273-4278.
6. Flamme I, Frohlich T, von Reutern M, et al. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels. Mech Dev 1997; 63: 51-60.
7. Stein I, Itin A, Einat P, et al. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: Implications for translation under hypoxia. Mol Cell Biol 1998; 18: 3112-3119.
8. Akiri G, Nahari D, Finkelstein Y, et al. Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription. Oncogene 1998; 17: 227-236.
9. Shi Q, Le X, Abbruzzese JL, et al. Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res 2001; 61: 4143-4154.
10. Dynan WS, Tjian R. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 1983; 35: 79-87.
11. Dynan WS, Tjian R. Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II. Cell 1983; 32: 669-680.
12. Dynan WS, Tjian R. Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins. Nature 1985; 316: 774-778.
13. Briggs MR, Kadonaga JT, Bell SP, et al. Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science 1986; 234: 47-52.
14. Kadonaga JT, Carner KR, Masiarz FR, et al. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 1987; 51: 1079-1090.
15. Suske G. The Sp-family of transcription factors. Gene 1999; 238: 291-300.
16. Lloyd J, Flanagan AM. Mammary and extramammary Paget's disease. J Clin Pathol 2000; 53: 742-749.
17. Ohnishi T, Watanabe S. The use of cytokeratins 7 and 20 in the diagnosis of primary and secondary extramammary Paget's disease. Br J Dermatol 2000; 142: 243-247.
18. Stoner M, Wormke M, Saville B, et al. Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor α and SP proteins. Oncogene 2004; 23: 1052-1063.
19. Pal S, Datta K, Mukhopadhyay D. Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/ VEGF) expression in mammary carcinoma. Cancer Res 2001; 61: 6952-6957.
20. Yao JC, Wang L, Wei D, et al. Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer. Clin Cancer Res 2004; 10: 4109-4117.
21. Silins G, Grimmond S, Egerton M, et al. Analysis of the promoter region of the human VEGF-related factor gene. Biochem Biophys Res Commun 1997; 230: 413-418.
22. Milanini J, Vinals F, Pouyssegur J, et al. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J Biol Chem 1998; 273: 18165-18172.
23. Kutoh E, Margot JB, Schwander J. Identification and characterization of the putative retinoblastoma control element of the rat insulin-like growth factor binding protein-2 gene. Cancer Lett 1999; 136: 187-194.
24. Zhang X, Li Y, Dai C, et al. Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney. Am J Physiol Renal Physiol 2003; 284: 82-94.
25. DiMario JX. Activation and repression of growth factor receptor gene transcription. Int J Mol Med 2002; 10: 65-71.
26. Parakati R, DiMario JX. Sp1- and Sp3-mediated transcriptional regulation of the fibroblast growth factor receptor 1 gene in chicken skeletal muscle cells. J Biol Chem 2002; 277: 9278-9285.
27. Patel SG, DiMario JX. Two distal Sp1-binding cis -elements regulate fibroblast growth factor receptor 1 (FGFR1) gene expression in myoblasts. Gene 2001; 270: 171-180.
28. Sorensen P, Wintersberger E. Sp1 and NF-Y are necessary and sufficient for growth-dependent regulation of the hamster thymidine kinase promoter. J Biol Chem 1999; 274: 30943-30949.
29. Milanini-Mongiat J, Pouyssegur J, Pages G. Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J Biol Chem 2002; 277: 20631-20639.
30. Merchant JLM, Todisco A. Sp1 phosphorylation by Erk 2 stimulates DNA binding. Biochem Biophys Res Commun 1999; 254: 454-461.
31. Liou H, Moroi Y, Yasumoto S, et al. Expression of insulin-like growth factor-1, p-AKT and p-ERK1/2 protein in extramammary Paget disease. Br J Dermatol 2006; 155: 586-591.
32. Ellis PE, Wong Te Fong LF, Rolfe KJ, et al. The role of vascular endothelial growth factor-A (VEGF-A) and platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) in Paget's disease of the vulva and breast. Anticancer Res 2002; 22: 857-861.