Pharmacokinetics of difloxacin in pigs and broilers following intravenous, intramuscular, and oral single-dose applications

Journal of Veterinary Pharmacology and Therapeutics

Volumn 31, Issue 3, 2008, Pages 200-204

  Ding, H Z ^a   Yang, G X ^a   Huang, X H ^a   Chen, Z L ^a   Zeng, Z L ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DIFLOXACIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; CHICKEN; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; SINGLE DRUG DOSE; SWINE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFECTIVE AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHICKENS; CIPROFLOXACIN; HALF-LIFE; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; SPECIES SPECIFICITY; SWINE; TISSUE DISTRIBUTION;

SUIDAE;

EID: 43549092237     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2008.00951.x     Document Type: Review

References (26)

1. Abd El-Aty, A.M., Goudah, A., Ismail, M. Shimoda, M. (2005) Disposition kinetics of difloxacin in rabbit after intravenous and intramuscular injection of Dicural. Veterinary Research Communication, 29, 297 304.
2. Adams, H.R. (2001) Veterinary pharmacology and therapeutics. In Fluoroquinolone Antimicrobial Drugs, 8th edn, Chapter 45. Eds Papich, M.G. Riviere, J.M., pp. 907. Iowa State University Press, Ames, IA.
3. Anadon, A., Martinez, M.R., Diaz, M.J., Fernandez, R., Martinez, M.A. Fernandez, M.C. (1994) Pharmacokinetic properties of norfloxacin in pigs. The Congress of 6th EVAPA, 17 Suppl. 1 230 231.
4. Bansal, M.B. Thadepalli, H. (1987) Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro. Antimicrobial Agents and Chemotherapy, 31, 619 621.
5. Boothe, D.M., Boeckh, A., Simpson, R.B. Dubose, K. (2006) Comparison of pharmacodynamic and pharmacokinetic indices of efficacy for 5 fluoroquinolones toward pathogens of dogs and cats. Journal of Veterinary Internal Medicine, 20, 1297 1306.
6. Brown, S.A. (1996) Fluoroquinolones in animal health. Journal of Veterinary Pharmacology and Therapeutics, 19, 1 14.
7. Digranes, A. Dibb, W.L. (1988) In vitro activities of A-56619 (difloxacin) and A-56620, two aryl-fluoroquinolones. Chemotherapy, 34, 298 307.
8. Ding, H.Z., Zeng, Z.L., Fung, K.F., Chen, Z.L. Qiao, G.L. (2001) Pharmacokinetics of sarafloxacin in pigs and broilers following intravenous, intramuscular, and oral single-dose applications. Journal of Veterinary Pharmacology and Therapeutics, 24, 303 308.
9. Eliopoulos, G.M., Moellering, A.E., Reiszner, E. Moellering, R.C. Jr. (1985) In vitro activities of the quinolone antimicrobial agents A-56619 and A-56620. Antimicrobial Agents and Chemotherapy, 28, 514 520.
10. Fang, B.H., Fung, K.F., Chen, Z.L. Wang, Z.Q. (1999) Bioavailability and pharmacokinetics of ciprofloxacin in pigs. Chinese Journal of Veterinary Science, 19, 588 590. (in Chinese)
11. Fernandes, P.B., Chu, D.T., Bower, R.R., Jarvis, K.P., Ramer, N.R. Shipkowitz, N. (1986) In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Antimicrobial Agents and Chemotherapy, 29, 201 208.
12. Fernandez-Varon, E., Carceles, C.M., Marin, P., Martos, N., Escudero, E. Ayala, I. (2006) Pharmacokinetics of difloxacin after intravenous, intramuscular, and intragastric administration to horses. American Journal of Veterinary Research, 67, 1076 1081.
13. Frazier, D.L., Thompson, L., Trettien, A. Evans, E.I. (2000) Comparison of fluoroquinolone pharmacokinetic parameters after treatment with marbofloxacin, enrofloxacin, and difloxacin in dogs. Journal of Veterinary Pharmacology and Therapeutics, 23, 293 302.
14. Heinen, E. (2002) Comparative serum pharmacokinetics of the fluoroquinolones enrofloxacin, difloxacin, marbofloxacin, and orbifloxacin in dogs after single oral administration. Journal of Veterinary Pharmacology and Therapeutics, 25, 1 5.
15. Inui, T., Taira, T., Matsushita, T. Endo, T. (1998) Pharmacokinetic properties and oral bioavailabilities of difloxacin in pig and chicken. Xenobiotica, 28, 887 893.
16. Ismail, M. (2007) Disposition kinetics of difloxacin after intravenous, intramuscular and subcutaneous administration in calves. Veterinary Research Communication, 31, 467 476.
17. Marin, P., Escudero, E., Fernandez-Varon, E. Carceles, C.M. (2007) Pharmacokinetics and milk penetration of difloxacin after intravenous, subcutaneous and intramuscular administration to lactating goats. Journal of Veterinary Pharmacology and Therapeutics, 30, 74 79.
18. Nilsson-Ehle, I. (1987) Assay of ciprofloxacin and norfloxacin in serum and urine by high-performance liquid chromatography. Journal of Chromatography, 416, 207 211.
19. Olchowy, T.W., TerHune, T.N. Herrick, R.L. (2000) Efficacy of difloxacin in calves experimentally infected with Mannheimia haemolytica. American Journal of Veterinary Research, 61, 710 713.
20. Richez, P., Pedersen Morner, A., De Jong, A. Monlouis, J.D. (1997) Plasma pharmacokinetics of parenterally administered danofloxacin and enrofloxacin in pigs. Journal of Veterinary Pharmacology and Therapeutics, 20 (Suppl 1 41 42.
21. Shojaee Aliabadi, F. Lees, P. (1997) Pharmacodynamic and pharmacokinetic inter-relationships of antibacterial drugs. Journal of Veterinary Pharmacology and Therapeutics, 20 (Suppl. 1 14 17.
22. Smith, B.R., Lefrock, J.L., Donato, J.B., Joseph, W.S. Weber, S.J. (1986) In vitro activity of A-56619 and A-56620, two new aryl-fluoroquinolone antimicrobial agents. Antimicrobial Agents and Chemotherapy, 29, 355 358.
23. Xian, W.J. Cheng, Z.R. (1988) MCPKP- a microcomputer program specialized for pharmacokinetic compartment analysis. Acta Pharmcologica Sinica, 9, 188 192. (in Chinese)
24. Zeng, Z. Fung, K. (1997) Effects of experimentally induced Escherichia coli infection on the pharmacokinetics of enrofloxacin in pigs. Journal of Veterinary Pharmacology and Therapeutics, 20 (Suppl. 1 39 40.
25. Zeng, Z.L., Liu, J.X., Chen, Z.L. Feng, Q.H. (2000) A comparison of enrofloxacin, danofloxacin, difloxacin in the treatment of experimental of Pasteurella multocida infection of chickens [J]. Journal of South China Agricultural University, 21, 82 84. (in Chinese)
26. Zeng, Z.L., Fang, B.H., Chen, Z.L., Feng, Q.H. Peng, X.F. (2001) Pharmacodynamics of difloxacin against experimentally induced Streptococcosis and Mycoplasmal pneumonia in pigs [J]. Acta Veterinaria et Zootechnica Sinica, 32, 175 180. (in Chinese)