The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia

European Journal of Neurology

Volumn 15, Issue 6, 2008, Pages 637-639

  Reif, A ^a   Scarpini, E ^b   Venturelli, E ^b   Topner T ^a   Fenoglio, C ^b   Lesch, K P ^a   Galimberti, D ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Genetics; MAOA uVNTR; Monoamine oxidase; Promoter polymorphism; Risk factor; VNTR

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); APOLIPOPROTEIN E4;

AGED; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DEMOGRAPHY; DISEASE DURATION; ENZYME DEFICIENCY; FEMALE; FRONTOTEMPORAL DEMENTIA; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR; SEX RATIO; VARIABLE NUMBER OF TANDEM REPEAT;

AGED; DEMENTIA; FEMALE; HUMANS; MALE; MONOAMINE OXIDASE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 43549090427     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2008.02142.x     Document Type: Article

References (13)

1. Bruni AC, Momeni P, Bernardi L, et al. Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation. Neurology 2007 69 : 140 147.
2. Knibb JA, Kipps CM, Hodges JR. Frontotemporal dementia. Current Opinion in Neurology 2006 19 : 565 571.
3. Le Ber I, van der Zee J, Hannequin D, et al. Progranulin null mutations in both sporadic and familial frontotemporal dementia. Human Mutation 2007 28 : 846 855.
4. Talbot K, Ansorge O. Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease. Human Molecular Genetics 2006 15 Spec No 2 : R182 R187.
5. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1993 262 : 578 580.
6. Cases O, Seif I, Grimsby J, et al. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995 268 : 1763 1766.
7. Deckert J, Catalano M, Syagailo YV, et al. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Human Molecular Genetics 1999 8 : 621 624.
8. Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics 1998 103 : 273 279.
9. Jacob CP, Muller J, Schmidt M, et al. Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. Neuropsychopharmacology 2005 30 : 1711 1718.
10. Reif A, Rosler M, Freitag CM, et al. Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment. Neuropsychopharmacology 2007 32 : 2375 2383.
11. Caspi A, McClay J, Moffitt TE, et al. Role of genotype in the cycle of violence in maltreated children. Science 2002 297 : 851 854.
12. Manuck SB, Flory JD, Ferrell RE, Mann JJ, Muldoon MF. A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Research 2000 95 : 9 23.
13. Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998 51 : 1546 1554.