Gestational exposure to atrazine: Effects on the postnatal development of male offspring

Journal of Andrology

Volumn 29, Issue 3, 2008, Pages 304-311

  Rosenberg, Brian G ^a   Chen, Haolin ^a   Folmer, Janet ^a   Liu, June ^a   Papadopoulos, Vassilios ^b   Zirkin, Barry R ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antiandrogen; Gestation; Leydig cells; Steroidogenesis

Indexed keywords

ATRAZINE; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOCRINE DISEASE; ENDOCRINE FUNCTION; FEMALE; FETUS; GESTATION PERIOD; MALE; NONHUMAN; POSTNATAL DEVELOPMENT; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROSTATE; RAT; SEMINAL VESICLE; SPRAGUE DAWLEY RAT; TESTOSTERONE BLOOD LEVEL;

ANIMALS; ANIMALS, NEWBORN; ATRAZINE; BIRTH WEIGHT; FEMALE; GENITALIA, MALE; HERBICIDES; MALE; MATERNAL EXPOSURE; PARTURITION; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TESTIS; TESTOSTERONE;

EID: 43449115126     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.107.003020     Document Type: Article

References (37)

1. Akingbemi BT, Youker RT, Sottas CM, Ge R, Datz E, Klinefelter GR, Zirkin BR, Hardy MP. Modulation of rat Leydig cell steroidogenic function by di-2-ethylhexyl phthalate. Biol Reprod. 2001;65:1252-1259.
2. Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science. 2005;308:1391-1392.
3. Baker DB. Herbicides in drinking water: a challenge for risk communication. In: Ballantine LG, McFarland JE, Hackett DS, eds. Triazine Herbicides Risk Assessment. ACS Symposium Series. Washington, DC: American Chemical Society; 1998:303-321.
4. Bowman CJ, Barlow NJ, Turner KJ, Wallace DG, Foster PM. Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci. 2003;74:393-406.
5. Colborn T, vom Saal FS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect. 1993;101:378-384.
6. Connor K, Howell J, Chen I, Liu H, Berhane K, Sciarretta C, Safe S, Zacharewski T. Failure of chloro-s-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro. Fund Appl Toxicol. 1996;30:93-101.
7. Cooper RL, Laws SC, Das PC, Narotsky MG, Goldman JM, Tyree EL, Stoker TE. Atrazine and reproductive function: mode and mechanism of action studies. Birth Defects Res (Part B). 2007;80:98-112.
8. Cooper RL, Stoker TE, Goldman JM, Parrish MB, Tyrey L. Effect of atrazine on ovarian function in the rat. Reprod Toxicol. 1996;10:257-264.
9. Cooper RL, Stoker TE, Tyrey L, Goldman JM, McElroy WK. Atrazine disrupts the hypothalamic control of pituitary-ovarian function. Toxicol Sci. 2000;53:297-307.
10. Eldridge J, Fleenor-Heyser D, Extrom P, Wetzel L, Breckenridge C, Gillis J, Luempert L, Stevens J. Short-term effects of chloroatrazines on estrus in female Sprague-Dawley and Fischer 344 rats. J Toxicol Environ Health. 1994a;43:155-167.
11. Eldridge J, Tennant M, Wetzel L, Breckenridge C, Stevens J. Factors affecting mammary tumor incidence in chloroatrazine-treated female rats: hormonal properties, dosage, and animal strain. Environ Health Perspect. 1994b;102:29-36.
12. Forest MG. Role of androgens in fetal and pubertal development. Horm Res. 1983;18:69-83.
13. Foster PMD. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl. 2006;29:140-147.
14. Friedmann AS. Atrazine inhibition of testosterone production in rat males following peripubertal exposure. Reprod Toxicol. 2002;16:275-279.
15. Gallavan RH Jr, Holson JF, Stump DG, Knapp JF, Reynolds VL. Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights. Reprod Toxicol. 1999;13:383-390.
16. Gray LE Jr, Ostby J, Furr J, Wolf CJ, Lambright C, Parks L, Veeramachaneni DN, Wilson V, Price M, Hotchkiss A, Orlando E, Guillette L. Effects of environmental antiandrogens on reproductive development in experimental animals. Hum Reprod. 2001;7:248-264.
17. Gray LE Jr, Wolf C, Lambright C, Mann P, Price M, Cooper RL, Ostby J. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozoloinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health. 1999;15:94-118.
18. Korenbrot C, Huhtaniemi I, Weiner R. Preputial separation as an external sign of pubertal development in the male rat. Biol Reprod. 1977;17:298-303.
19. McIntyre BS, Barlow NJ, Foster PM. Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. Toxicol Sci. 2001;62:236-249.
20. Murono EP, Derk RC, de Leon JH. Octylphenol inhibits testosterone biosynthesis by cultured precursor and immature Leydig cells from rat testes. Reprod Toxicol. 2000;14:275-288.
21. Mylchreest E, Wallace DG, Cattley RC, Foster PM. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl)phthalate during late gestation. Toxicol Sci. 2000;55:143-151.
22. Narotsky MG, Best DS, Guidici DL, Cooper RL. Strain comparisons of atrazine-induced pregnancy loss in the rat. Reprod Toxicol. 2001;15:61-69.
23. Rayner JL, Enoch RR, Wolf DC, Fenton SE. Atrazine-induced reproductive tract alterations after transplacental and/or lactational exposure in male Long-Evans rats. Toxicol Appl Pharmacol. 2007;218:238-248.
24. Rayner JL, Wood C, Fenton SE. Exposure parameters necessary for delayed puberty and mammary gland development in Long-Evans rats exposed in utero to atrazine. Toxicol Appl Pharmacol. 2004;195:23-34.
25. Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993;341:1392-1395.
26. Simic B, Kniewald J, Kniewald Z. Effects of atrazine on reproductive performance in the rat. J Appl Toxicol. 1994;14:401-404.
27. Stevens JT, Breckenridge CB, Wetzel L, Thakur AK, Liu C, Werner C, Luempert LG, Eldridge JC. A risk characterization for atrazine: oncogenicity profile. J Toxicol Environ Health. 1999;56:69-109.
28. Stoker TE, Laws SC, Guidici DL, Cooper RL. The effect of atrazine on puberty in male Wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function. Toxicol Sci. 2000;58:50-59.
29. Stoker TE, Robinette CL, Cooper RL. Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring. Toxicol Sci. 1999;52:68-79.
30. Tennant MK, Hill DS, Eldridge JC, Wetzel LT, Breckenridge CB, Stevens JT. Possible antiestrogenic properties of chloro-s-triazines in rat uterus. J Toxicol Environ Health. 1994;43:183-196.
31. Toppari J, Larsen JC, Christiansen P, Giwercam A, Grandjean P, Guillette LJ. Male reproductive health and environmental xenoestrogens. Environ Health Perspect. 1996;104(suppl 4):741-803.
32. Trentacoste SV, Friedmann AS, Youker RT, Breckenridge CB, Zirkin BR. Atrazine effects on testosterone levels and androgen-dependent reproductive organs in peripubertal male rats. J Androl. 2001;22:142-148.
33. Turner TT, Jones CE, Howards SS, Ewing LL, Zegeye B, Gunsalus GL. On the androgen microenvironment of maturing spermatozoa. Endocrinology. 1984;115:1925-1932.
34. Varma SK, Bloch E. Effects of prenatal administration of mestranol and two progestins on testosterone synthesis and reproductive tract development in male rats. Acta Endocrinol (Copenh). 1987;116:193-199.
35. Walsh LP, Webster DR, Stocco DM. Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene. J Endocrinol. 2000;167:253-263.
36. Wetzel L, Luempert L, Breckenridge C, Tisdel M, Stevens J, Thakur A, Extrom P, Eldridge J. Chronic effects of atrazine on estrus and mammary tumor formation in female Sprague Dawley and Fischer 344 rats. J Toxicol Environ Health. 1994;43:169-182.
37. Wilson MJ. Inhibition of development of both androgen-dependent and androgen-independent pigment cells in scrotal skin dermis of the rat by antiandrogen treatment during fetal growth. Endocrinology. 1983;122:321-325.