Consolidation treatment with rituximab induces complete and persistent remission of mixed type Evans syndrome

Blood Coagulation and Fibrinolysis

Volumn 19, Issue 4, 2008, Pages 315-318

  Rodella, Elisabetta ^a   Pacquola, Enrica ^a   Bianchini, Enzo ^a   Ramazzina, Emilio ^a   Paolini, Rossella ^a,b  

^a S MARIA DELLA MISERICORDIA HOSPITAL   (Italy)

^b Ospedale S Maria della Misericordia   (Italy)

Author keywords

Evans syndrome; Immune thrombocytopenic purpura; Mixed type autoimmune haemolytic anaemia; Pulmonary embolism; Rituximab

Indexed keywords

CYCLOPHOSPHAMIDE; HAPTOGLOBIN; HEMOGLOBIN; IMMUNOGLOBULIN; LACTATE DEHYDROGENASE; PREDNISONE; RITUXIMAB;

ADULT; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; CASE REPORT; DISEASE SEVERITY; DRUG DOSE REDUCTION; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; LACTATE DEHYDROGENASE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECURRENT DISEASE; RELAPSE; REMISSION; TREATMENT DURATION; TREATMENT RESPONSE;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANTIBODIES, MONOCLONAL; DISEASE-FREE SURVIVAL; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IMMUNOLOGIC FACTORS; MIDDLE AGED; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; REMISSION INDUCTION; SALVAGE THERAPY; SYNDROME;

EID: 43449114824     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e3282f9ae12     Document Type: Article

References (22)

1. Dacie J. The autoimmune haemolytic anaemias: introduction. In: Dacie J, (editor). The haemolytic anaemias. Vol. 3. London: Churchill Livingstone, Inc.; 1992. pp. 1-5.
2. Berentsen S, Ulvestad E, Langholm R, Beiske K, Hjorth-Hansen H, Ghanima W, et al. Primary chronic cold agglutinin disease: a population based clinical study of 86 patients. Haematologica 2006; 91:460-466.
3. Shulman IA, Branch DR, Nelson JM, Thompson JC, Saxena S, Petz LD. Autoimmune hemolytic anemia with both cold and warm autoantibodies. JAMA 1985; 253:1746-1748.
4. Norton A, Roberts I. Management of Evans syndrome. Br J Haematol 2006; 132:125-137.
5. Petz LD. Treatment of autoimmune haemolytic anaemias. Curr Opin Haematol 2001; 8:411-416.
6. Shanafelt TD, Madueme HL, Wolf RC, Tefferi A. Rituximab for immune cytopenia in adults: idiopatic thrombocytopenic purpura, autoimmune hemolytic anemia, and Evans Syndrome. Mayo Clin Proc 2003; 78:1340-1346.
7. Mantadakis E, Danilatou V, Stiakaki E, Kalmanti N. Rituximab for refractory Evans Syndrome of immune-mediated hematology diseases. Am J Hematol 2004; 77:303-310.
8. Arnold DM, Dentali F, Crowther MA, Meyer RM, Cook RJ, Sigouin C, et al. Systematic review: efficacy and safety of rituximab for adults with ITP. Ann Intern Med 2007; 146:25-33.
9. Bromberg ME. Immune thrombocytopenic purpura-the changing therapeutic landscape. N Engl J Med 2006; 355:1643-1645.
10. Zecca M, De Stefano P, Nobili B, Locatelli F. Anti-CD20 monoclonal antibody for the treatment of severe, immune-mediated, pure red cell aplasia and haemolytic anaemia. Blood 2001; 97:3995-3997.
11. Kerridge I, Hann I, Ethel M, Potter M, Prentice HG. Anti-CD20 monoclonal antibody (rituximab) therapy in a child with refractory chronic autoimmune haemolytic anaemia. Intern Med J 2003; 33:544.
12. McMahon C, Babu L, Hodgson A, Hayat A, Connell NO, Smith OP. Childhood refractory autoimmune haemolytic anaemia: is there a role for anti-CD20 therapy (rituximab)? Br J Haematol 2002; 117:480-482.
13. Quartier P, Brethon B, Philippet P, Landman-Parker J, Le Deist F, Fischer A. Treatment of childhood autoimmune haemolytic anaemia with rituximab. Lancet 2001; 358:1511-1513.
14. Zecca M, Nobili B, Ramenghi U, Perrotta S, Amendola G, Rosito P, et al. Rituximab for the treatment of refractory autoimmune hemolytic anemia in children. Blood 2003; 101:3857-3861.
15. Motto DG, Williams JA, Boxer LA. Rituximab for refractory childhood autoimmune hemolytic anemia. Isr Med Assoc J 2002; 4:1006-1008.
16. Ramanathan S, Koutts J, Hertzberg MS. Two cases of refractory warm autoimmune haemolytic anaemia treated with rituximab. Am J Hematol 2005; 78:123-126.
17. Morselli M, Luppi M, Potenza L, Tonelli S, Dini D, Leopardi G, et al. Mixed cold and warm autoimmune haemolytic anaemia: complete recovery after 2 courses of rituximab treatment. Blood 2002; 99:3478-3479.
18. Webster D, Ritchie B, Mant MJ. Prompt response to rituximab of severe haemolytic anaemia with both cold and warm antibodies. Am J Hematol 2004; 75:258-259.
19. Jubinsky PT, Rashid N. Successful treatment of a patient with mixed warm and cold antibody mediated Evans syndrome and glucose intolerance. Pediatr Blood Cancer 2005; 44:1-4.
20. Park CY, Chung CH. A patient with mixed type Evans syndrome: efficacy of rituximab treatment. J Korean Med Sci 2006; 21:1115-1116.
21. Urban C, Benesch M, Sovinz P, Schwinger W, Lackner H. Fatal Evans' syndrome after matched unrelated donor transplantation for hyper-IgM syndrome. Eur J Haematol 2004; 72:444-447.
22. Sokol RJ, Hewitt S, Stamps BK. Autoimmune haemolysis: mixed warm and cold antibody type. Acta Haematol 1983; 69:266-274.