Proposed reference value of the CA 125 tumour marker in men. Potential applications in clinical practice

Clinical Biochemistry

Volumn 41, Issue 9, 2008, Pages 717-722

  Barcelo B ^a   Ayllon O ^a   Belmonte, M ^a   Barcelo A ^a   Vidal, R ^a   Forteza Rey, J ^a   Gutierrez A ^a  

^a HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

Author keywords

CA 125; Heart failure; Non Hodgkin lymphoma; Reference value

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CA 125 ANTIGEN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CLINICAL PRACTICE; DISEASE COURSE; HEART FAILURE; HUMAN; IMMUNOASSAY; KIDNEY FUNCTION; LIVER FUNCTION; MALE; NONHODGKIN LYMPHOMA; NORMAL HUMAN; OVARY CANCER; PANCREAS FUNCTION; PRIORITY JOURNAL; REFERENCE VALUE; THYROID FUNCTION;

ADULT; AGED; CA-125 ANTIGEN; FEMALE; HUMANS; IMMUNOASSAY; MALE; MIDDLE AGED; OVARIAN NEOPLASMS; REFERENCE STANDARDS; REFERENCE VALUES; TUMOR MARKERS, BIOLOGICAL;

EID: 43449112040     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2008.02.016     Document Type: Article

References (36)

1. Kabawat S.E., Bast Jr. R.C., Bhan A.K., Welch W.R., Knapp R.C., and Colvin R.B. Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125. Int J Gynecol Pathol 2 3 (1983) 275-285
2. Bast Jr. R.C., Feeney M., Lazarus H., Nadler L.M., Colvin R.B., and Knapp R.C. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 68 5 (Nov 1981) 1331-1337
3. Canney P.A., Moore M., Wilkinson P.M., and James R.D. Ovarian cancer antigen CA125: a prospective clinical assessment of its role as a tumour marker. Br J Cancer 50 6 (Dec 1984) 765-769
4. Bast Jr. R.C., Klug T.L., St J.E., Jenison E., Niloff J.M., Lazarus H., et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 309 15 (Oct 13 1983) 883-887
5. Pauler D.K., Menon U., McIntosh M., Symecko H.L., Skates S.J., and Jacobs I.J. Factors influencing serum CA125II levels in healthy postmenopausal women. Cancer Epidemiol Biomarkers Prev 10 5 (May 2001) 489-493
6. Alagoz T., Buller R.E., Berman M., Anderson B., Manetta A., and DiSaia P. What is a normal CA125 level?. Gynecol Oncol 53 1 (Apr 1994) 93-97
7. Barcelo B., Barcelo A., Riesco M., Perez G., Castanyer B., and Vila M. Variabilidad de las concentraciones sericas de CA 125 mujeres sanas en funcion de la edad, situacion hormanal y otras condiciones. Clin Invest Gin Obst 33 4 (2006) 122-129
8. Zurawski Jr. V.R., Orjaseter H., Andersen A., and Jellum E. Elevated serum CA 125 levels prior to diagnosis of ovarian neoplasia: relevance for early detection of ovarian cancer. Int J Cancer 42 5 (Nov 15 1988) 677-680
9. Nagele H., Bahlo M., Klapdor R., Schaeperkoetter D., and Rodiger W. CA 125 and its relation to cardiac function. Am Heart J 137 6 (Jun 1999) 1044-1049
10. D'Aloia A., Faggiano P., Aurigemma G., Bontempi L., Ruggeri G., Metra M., et al. Serum levels of carbohydrate antigen 125 in patients with chronic heart failure: relation to clinical severity, hemodynamic and Doppler echocardiographic abnormalities, and short-term prognosis. J Am Coll Cardiol 41 10 (May 21 2003) 1805-1811
11. Nunez J., Nunez E., Consuegra L., Sanchis J., Bodi V., Martinez-Brotons A., et al. Carbohydrate antigen 125: an emerging prognostic risk factor in acute heart failure?. Heart 93 6 (Jun 2007) 716-721
12. Zacharos I.D., Efstathiou S.P., Petreli E., Georgiou G., Tsioulos D.I., Mastorantonakis S.E., et al. The prognostic significance of CA 125 in patients with non-Hodgkin's lymphoma. Eur J Haematol 69 4 (Oct 2002) 221-226
13. Zidan J., Hussein O., Basher W., and Zohar S. Serum CA125: a tumor marker for monitoring response to treatment and follow-up in patients with non-Hodgkin's lymphoma. Oncologist 9 4 (2004) 417-421
14. Izes J.K., Dyer M.W., Callum M.G., Bankes P., Libertino J.A., and Caffrey J.A. Ca 125 as a marker of tumor activity in advanced urothelial malignancy. J Urol 165 6 Pt 1 (Jun 2001) 1908-1913
15. Chaube A., Tewari M., Singh U., and Shukla H.S. CA 125: a potential tumor marker for gallbladder cancer. J Surg Oncol 93 8 (2006) 665-669
16. Bon G.G., Kenemans P., Verstraeten R., van Kamp G.J., and Hilgers J. Serum tumor marker immunoassays in gynecologic oncology: establishment of reference values. Am J Obstet Gynecol 174 1 Pt 1 (Jan 1996) 107-114
17. Corteville D.C., Bibbins-Domingo K., Wu A.H., Ali S., Schiller N.B., and Whooley M.A. N-terminal pro-B-type natriuretic peptide as a diagnostic test for ventricular dysfunction in patients with coronary disease: data from the heart and soul study. Arch Intern Med 167 5 (Mar 12 2007) 483-489
18. Miralles C., Orea M., Espana P., Provencio M., Sanchez A., Cantos B., et al. Cancer antigen 125 associated with multiple benign and malignant pathologies. Ann Surg Oncol 10 2 (2006) 150-154
19. Ricos C., Alvarez V., Cava F., Garcia-Lario J.V., Hernandez A., Jimenez C.V., et al. Current databases on biological variation: pros, cons and progress. Scand J Clin Lab Invest 59 7 (Nov 1999) 491-500
20. Bonfrer J.M., Korse C.M., Verstraeten R.A., van Kamp G.J., Hart G.A., and Kenemans P. Clinical evaluation of the Byk LIA-mat CA125 II assay: discussion of a reference value. Clin Chem 43 3 (Mar 1997) 491-497
21. Van Ingen H.E., Chan D.W., Hubl W., Miyachi H., Molina R., Pitzel L., et al. Analytical and clinical evaluation of an electrochemiluminescence immunoassay for the determination of CA 125. Clin Chem 44 12 (Dec 1998) 2530-2536
22. Rubin S.C., Hoskins W.J., Hakes T.B., Markman M., Reichman B.S., Chapman D., et al. Serum CA 125 levels and surgical findings in patients undergoing secondary operations for epithelial ovarian cancer. Am J Obstet Gynecol 160 3 (Mar 1989) 667-671
23. Zurawski Jr. V.R., Sjovall K., Schoenfeld D.A., Broderick S.F., Hall P., Bast Jr. R.C., et al. Prospective evaluation of serum CA 125 levels in a normal population, phase I: the specificities of single and serial determinations in testing for ovarian cancer. Gynecol Oncol 36 3 (Mar 1990) 299-305
24. Varol E., Ozaydin M., Altinbas A., Aslan S.M., Dogan A., and Dede O. Elevated carbohydrate antigen 125 levels in hypertrophic cardiomyopathy patients with heart failure. Heart Vessels 22 1 (Jan 2007) 30-33
25. Skorzynska H., Solski J., Gernand W., Matras P., Gniwek M., and Sokol M. Estimation of CA 125 concentration in patients with congestive heart failure. Ann Univ Mariae Curie Sklodowska [Med] 59 1 (2004) 261-264
26. Lazzarino M., Orlandi E., Klersy C., Astori C., Brusamolino E., Corso A., et al. Serum CA 125 is of clinical value in the staging and follow-up of patients with non-Hodgkin's lymphoma: correlation with tumor parameters and disease activity. Cancer 82 3 (Feb 1 1998) 576-582
27. Faggiano P., D'Aloia A., Bignotti T., and Dei C.L. One biologic marker (carbohydrate antigen-CA 125), two different diseases (ovarian cancer and congestive heart failure): practical implications of monitoring CA 125 serum levels. A case report. Ital Heart J 4 7 (Jul 2003) 497-499
28. Hopman E.H., Helmerhorst T.J., Bonfrer J.M., and ten Bokkel Huinink W.W. Highly elevated serum CA 125 levels in a patient with cardiac failure. Eur J Obstet Gynecol Reprod Biol 48 1 (Jan 1993) 71-73
29. Silberstein L.B., Rosenthal A.N., Coppack S.W., Noonan K., and Jacobs I.J. Ascites and a raised serum Ca 125 confusing combination. J R Soc Med 94 11 (Nov 2001) 581-582
30. Faggiano, D'Aloia A., Brentana L., Bignotti T., Fiorina C., Vizzardi E., et al. Serum levels of different tumour markers in patients with chronic heart failure. Eur J Heart Fail 7 1 (2006) 57-61
31. Green P.J., Ballas S.K., Westkaemper P., Schwartz H.G., Klug T.L., and Zurawski Jr. V.R. CA 19-9 and CA 125 levels in the sera of normal blood donors in relation to smoking history. J Natl Cancer Inst 77 2 (2006) 337-341
32. Tuxen M.K., Soletormos G., Rustin G.J., Nelstrop A.E., and Dombernowsky P. Biological variation and analytical imprecision of CA 125 in patients with ovarian cancer. Scand J Clin Lab Invest 60 8 (2006) 713-721
33. Kouris N.T., Zacharos I.D., Kontogianni D.D., Goranitou G.S., Sifaki M.D., Grassos H.E., et al. The significance of CA125 levels in patients with chronic congestive heart failure. Correlation with clinical and echocardiographic parameters. Eur J Heart Fail 7 2 (2006) 199-203
34. Symeonidis A., Kouraklis-Symeonidis A., Apostolopoulos D., Arvanitopoulou E., Giannakoulas N., Vassilakos P., et al. Increased serum CA-15.3 levels in patients with megaloblastic anemia due to vitamin B12 deficiency. Oncology 67 5-6 (2006) 359-367
35. Kanehara H., Bando Y., Tomita M., Kontani M., Takegoshi Y., and Tanaka N. Myxedema ascites with an extremely elevated CA125 level: a case report. Endocr J 54 4 (Sep 2007) 601-604
36. Takahashi N., Shimada T., Ishibashi Y., Oyake N., and Murakami Y. Transient elevation of serum tumor markers in a patient with hypothyroidism. Am J Med Sci 333 6 (Jun 2007) 387-389