Morphological skin ageing criteria by multiphoton laser scanning tomography: Non-invasive in vivo scoring of the dermal fibre network

Experimental Dermatology

Volumn 17, Issue 6, 2008, Pages 519-523

  Koehler, Martin Johannes ^a   Hahn, Stefanie ^a   Preller, Anja ^a   Elsner, Peter ^a   Ziemer, Mirjana ^a   Bauer, Andrea ^a   König, Karsten ^b   Bückle, Rainer ^c   Fluhr, Joachim W ^a,d   Kaatz, Martin ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b FRAUNHOFER INSTITUTE FOR BIOMEDICAL ENGINEERING   (Germany)

^c JENLAB GMBH   (Germany)

^d Bioskin   (Germany)

Author keywords

Collagen; Elastin; In vivo scoring; Multiphoton laser tomography; Skin ageing

Indexed keywords

COLLAGEN FIBER; ELASTIN;

ADULT; AGE; AGED; ARTICLE; AUTOFLUORESCENCE; CAUCASIAN; CELL STRUCTURE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CORRELATION ANALYSIS; CUTANEOUS PARAMETERS; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MALE; MORPHOLOGY; NON INVASIVE MEASUREMENT; NORMAL HUMAN; QUANTITATIVE ANALYSIS; SCORING SYSTEM; SKIN CELL; SKIN DISEASE; VOLUNTEER;

ADULT; AGED; AGED, 80 AND OVER; COLLAGEN; DERMIS; DERMOSCOPY; ELASTIN; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LASERS; LINEAR MODELS; MALE; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; REFERENCE VALUES; SKIN AGING; SKIN DISEASES; TOMOGRAPHY;

EID: 43449110483     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2007.00669.x     Document Type: Article

References (44)

1. Varani J, Warner R L, Gharaee-Kermani M et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000: 114: 480-486.
2. Okazaki M, Yoshimura K, Uchida G et al. Correlation between age and the secretions of melanocyte-stimulating cytokines in cultured keratinocytes and fibroblasts. Br J Dermatol 2005: 153 (Suppl. 2): 23-29.
3. Placzek M, Kerkmann U, Bell S et al. Tobacco smoke is phototoxic. Br J Dermatol 2004: 150: 991-993.
4. Kennedy C, Bastiaens M T, Bajdik C D et al. Effect of smoking and sun on the aging skin. J Invest Dermatol 2003: 120: 548-554.
5. Varani J, Perone P, Fligiel S E et al. Inhibition of type I procollagen production in photodamage: Correlation between presence of high molecular weight collagen fragments and reduced procollagen synthesis. J Invest Dermatol 2002: 119: 122-129.
6. Fisher G J, Voorhees J J. Molecular mechanisms of photoaging and its prevention by retinoic acid: Ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Investig Dermatol Symp Proc 1998: 3: 61-68.
7. Knuutinen A, Kokkonen N, Risteli J et al. Smoking affects collagen synthesis and extracellular matrix turnover in human skin. Br J Dermatol 2002: 146: 588-594.
8. Chen V L, Fleischmajer R, Schwartz E et al. Immunochemistry of elastotic material in sun-damaged skin. J Invest Dermatol 1986: 87: 334-337.
9. Bernstein E F, Underhill C B, Hahn P J et al. Chronic sun exposure alters both the content and distribution of dermal glycosaminoglycans. Br J Dermatol 1996: 135: 255-262.
10. Sellheyer K. Pathogenesis of solar elastosis: Synthesis or degradation? J Cutan Pathol 2003: 30: 123-127.
11. Sakai L Y, Keene D R, Engvall E. Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. J Cell Biol 1986: 103: 2499-2509.
12. Saarialho-Kere U, Kerkela E, Jeskanen L et al. Accumulation of matrilysin (MMP-7) and macrophage metalloelastase (MMP-12) in actinic damage. J Invest Dermatol 1999: 113: 664-672.
13. Naru E, Suzuki T, Moriyama M et al. Functional changes induced by chronic UVA irradiation to cultured human dermal fibroblasts. Br J Dermatol 2005: 153 (Suppl. 2): 6-12.
14. Hayashi A, Ryu A, Suzuki T et al. In vitro degradation of tropoelastin by reactive oxygen species. Arch Dermatol Res 1998: 290: 497-500.
15. Inomata S, Matsunaga Y, Amano S et al. Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse. J Invest Dermatol 2003: 120: 128-134.
16. Amano S, Ogura Y, Akutsu N et al. Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: skin equivalents partially mimic photoageing process. Br J Dermatol 2005: 153 (Suppl. 2): 37-46.
17. Sander C S, Chang H, Salzmann S et al. Photoaging is associated with protein oxidation in human skin in vivo. J Invest Dermatol 2002: 118: 618-625.
18. Blatt T, Lenz H, Koop U et al. Stimulation of skin's energy metabolism provides multiple benefits for mature human skin. Biofactors 2005: 25: 179-185.
19. Lenz H, Schmidt M, Welge V et al. The creatine kinase system in human skin: Protective effects of creatine against oxidative and UV damage in vitro and in vivo. J Invest Dermatol 2005: 124: 443-452.
20. Chiu A, Kimball A B. Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. Br J Dermatol 2003: 149: 681-691.
21. Vayalil P K, Mittal A, Hara Y et al. Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. J Invest Dermatol 2004: 122: 1480-1487.
22. Son E D, Lee J Y, Lee S et al. Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo. J Invest Dermatol 2005: 124: 1149-1161.
23. Shin M H, Rhie G E, Park C H et al. Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin. J Invest Dermatol 2005: 124: 315-323.
24. Kambayashi H, Odake Y, Takada K et al. N-retinoyl-d-glucosamine, a new retinoic acid agonist, mediates topical retinoid efficacy with no irritation on photoaged skin. Br J Dermatol 2005: 153 (Suppl. 2): 30-36.
25. Jimenez F, Mitts T F, Liu K et al. Ellagic and tannic acids protect newly synthesized elastic fibers from premature enzymatic degradation in dermal fibroblast cultures. J Invest Dermatol 2006: 126: 1272-1280.
26. Gniadecka M, Jemec G B. Quantitative evaluation of chronological ageing and photoageing in vivo: Studies on skin echogenicity and thickness. Br J Dermatol 1998: 139: 815-821.
27. Cossmann M, Welzel J. Evaluation of the atrophogenic potential of different glucocorticoids using optical coherence tomography, 20-MHz ultrasound and profilometry; a double-blind, placebo-controlled trial. Br J Dermatol 2006: 155: 700-706.
28. Stamatas G N, Estanislao R B, Suero M et al. Facial skin fluorescence as a marker of the skin's response to chronic environmental insults and its dependence on age. Br J Dermatol 2006: 154: 125-132.
29. Gorzelanny C, Goerge T, Schnaeker E M et al. Atomic force microscopy as an innovative tool for nanoanalysis of native stratum corneum. Exp Dermatol 2006: 15: 387-391.
30. Stracke F, Weiss B, Lehr C M et al. Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs. J Invest Dermatol 2006: 126: 2224-2233.
31. Yu B, Kim K H, So P T et al. Visualization of oleic acid-induced transdermal diffusion pathways using two-photon fluorescence microscopy. J Invest Dermatol 2003: 120: 448-455.
32. Mulholland W J, Arbuthnott E A, Bellhouse B J et al. Multiphoton high-resolution 3D imaging of Langerhans cells and keratinocytes in the mouse skin model adopted for epidermal powdered immunization. J Invest Dermatol 2006: 126: 1541-1548.
33. Yeh A T, Choi B, Nelson J S et al. Reversible dissociation of collagen in tissues. J Invest Dermatol 2003: 121: 1332-1335.
34. Sun Y, Chen W L, Lin S J et al. Investigating mechanisms of collagen thermal denaturation by high resolution second-harmonic generation imaging. Biophys J 2006: 91: 2620-2625.
35. Koehler M J, Konig K, Elsner P et al. In vivo assessment of human skin aging by multiphoton laser scanning tomography. Opt Lett 2006: 31: 2879-2881.
36. Zoumi A, Lu X, Kassab G S et al. Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy. Biophys J 2004: 87: 2778-2786.
37. Konig K, Riemann I. High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution. J Biomed Opt 2003: 8: 432-439.
38. Muto J, Kuroda K, Wachi H et al. Accumulation of elafin in actinic elastosis of sun-damaged skin: Elafin binds to elastin and prevents elastolytic degradation. J Invest Dermatol 2006: 127: 1358-1366.
39. Tasanen K, Palatsi R, Oikarinen A. Demonstration of increased levels of type I collagen mRNA using quantitative polymerase chain reaction in fibrotic and granulomatous skin diseases. Br J Dermatol 1998: 139: 23-26.
40. Levi-Schaffer F, Nagler A, Slavin S et al. Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: Effect of halofuginone. J Invest Dermatol 1996: 106: 84-88.
41. Bhattacharyya T K, Thomas J R. Histomorphologic changes in aging skin: observations in the CBA mouse model. Arch Facial Plast Surg 2004: 6: 21-25.
42. Warren R, Gartstein V, Kligman A M et al. Age, sunlight, and facial skin: A histologic and quantitative study. J Am Acad Dermatol 1991: 25: 751-760.
43. West M D. The cellular and molecular biology of skin aging. Arch Dermatol 1994: 130: 87-95.
44. Rajadhyaksha M, Grossman M, Esterowitz D et al. In vivo confocal scanning laser microscopy of human skin: Melanin provides strong contrast. J Invest Dermatol 1995: 104: 946-952.