Effect of aging on neurogenesis in the canine brain

Aging Cell

Volumn 7, Issue 3, 2008, Pages 368-374

  Pekcec, Anton ^a   Baumgärtner, Wolfgang ^b,c   Bankstahl, Jens P ^b,c   Stein, Veronika M ^c   Potschka, Heidrun ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

^c UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Aging; Alzheimer's disease; Double cortin; Ki 67; Neurogenesis; Neuronal progenitor

Indexed keywords

AMYLOID BETA PROTEIN; DOUBLECORTIN; KI 67 ANTIGEN;

AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CELL LABELING; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DOG; ENVIRONMENTAL EXPOSURE; FEMALE; HIPPOCAMPUS; MALE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENILE PLAQUE;

ANIMALS; BRAIN; CELL AGING; CELL PROLIFERATION; DOGS; KI-67 ANTIGEN; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; NEUROPEPTIDES; STEM CELLS;

CANIS FAMILIARIS; RODENTIA;

EID: 43449102186     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2008.00392.x     Document Type: Article

References (30)

1. Alvarez-Buylla A, Garcia-Verdugo JM (2002) Neurogenesis in adult subventricular zone. J. Neurosci. 22, 629-634.
2. Bai J, Ramos RL, Ackman JB, Thomas AM, Lee RV, LoTurco JJ (2003) RNAi reveals doublecortin is required for radial migration in rat neocortex. Nat. Neurosci. 6, 1277-1283.
3. Beyreuther K, Masters CL (1991) Amyloid precursor protein (APP) and beta A4 amyloid in the etiology of Alzheimer's disease: Precursor-product relationships in the derangement of neuronal function. Brain Pathol. 1, 241-251.
4. Brown JP, Couillard-Despres S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG (2003) Transient expression of doublecortin during adult neurogenesis. J. Comp. Neurol. 467, 1-10.
5. Bruel-Jungerman E, Laroche S, Rampon C (2005) New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur. J. Neurosci. 21, 513-521.
6. Cooper-Kuhn CM, Kuhn HG (2002) Is it all DNA repair? Methodological considerations for detecting neurogenesis in the adult brain. Brain Res. Dev. Brain Res. 134, 13-21.
7. Corbo JC, Deuel TA, Long JM, LaPorte P, Tsai E, Wynshaw-Boris A, Walsh CA (2002) Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J. Neurosci. 22, 7548-7557.
8. Couillard-Despres S, Winner B, Schaubeck S, Aigner R, Vroemen M, Weidner N, Bogdahn U, Winkler J, Kuhn HG, Aigner L (2005) Doublecortin expression levels in adult brain reflect neurogenesis. Eur. J. Neurosci. 21, 1-14.
9. Czasch S, Paul S, Baumgartner W (2006) A comparison of immunohistochemical and silver staining methods for the detection of diffuse plaques in the aged canine brain. Neurobiol. Aging 27, 293-305.
10. Gressens P (2006) Pathogenesis of migration disorders. Curr. Opin. Neurol. 19, 135-140.
11. Hattiangady B, Shetty AK (2008) Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus. Neurobiol. Aging 29, 129-147.
12. Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW (1998) Visual-discrimination learning ability and β-amyloid accumulation in the dog. Neurobiol. Aging 19, 415-425.
13. Jin K, Peel AL, Mao XO, Xie L, Cottrell BA, Henshall DC, Greenberg DA (2004) Increased hippocampal neurogenesis in Alzheimer's disease. Proc. Natl Acad. Sci. USA 101, 343-347.
14. Kempermann G, Gast D, Gage FH (2002) Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann. Neurol. 52, 135-143.
15. Kempermann G, Jessberger S, Steiner B, Kronenberg G (2004a) Milestones of neuronal development in the adult hippocampus. Trends Neurosci. 27, 447-452.
16. Kempermann G, Wiskott L, Gage FH (2004b) Functional significance of adult neurogenesis. Curr. Opin. Neurobiol. 14, 186-191.
17. Kuhn HG, Dickinson-Anson H, Gage FH (1996) Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16, 2027-2033.
18. Landsberg G (2005) Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs. Prog. Neuropsychopharmacol. Biol. Psychiatry 29, 471-479.
19. Landsberg G, Araujo JA (2005) Behavior problems in geriatric pets. Vet. Clin. North Am. Small Anim. Pract. 35, 675-698.
20. McDonald HY, Wojtowicz JM (2005) Dynamics of neurogenesis in the dentate gyrus of adult rats. Neurosci. Lett. 385, 70-75.
21. Nacher J, Alonso-Llosa G, Rosell DR, McEwen BS (2003) NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus. Neurobiol. Aging 24, 273-284.
22. van Praag H, Kempermann G, Gage F (1999) Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2, 266-270.
23. Rao MS, Hattiangady B, Shetty AK (2006) The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampus. Aging Cell 5, 545-558.
24. Rao MS, Shetty AK (2004) Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus. Eur. J. Neurosci. 19, 234-246.
25. Shapiro LA, Ng KL, Kinyamu R, Whitaker-Azmitia P, Geisert EE, Blurton-Jones M, Zhou QY, Ribak CE (2007) Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex. Brain Struct. Funct. 212, 133-148.
26. Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E (2001) Neurogenesis in the adult is involved in the formation of trace memories. Nature 410, 372-376.
27. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW (2007) Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol. Learn. Mem. 88, 249-259.
28. Tanapat P, Hastings NB, Reeves AJ, Gould E (1999) Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J. Neurosci. 19, 5792-5801.
29. Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY (2004) Frontal lobe volume, function, and β-amyloid pathology in a canine model of aging. J. Neurosci. 24, 8205-8213.
30. Winocur G, Wojtowicz JM, Sekeres M, Snyder JS, Wang S (2006) Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16, 296-304.