Circulating levels of VCAM and MMP-2 may help identify patients with more aggressive prostate cancer

Current Cancer Drug Targets

Volumn 8, Issue 3, 2008, Pages 199-206

  De Cicco, Concetta ^a   Ravasi, Laura ^b   Zorzino, Laura ^a   Sandri, Maria Teresa ^a   Botteri, Edoardo ^a   Verweij, Fabrizio ^a   Granchi, Donatella ^c   De Cobelli, Ottavio ^a   Paganelli, Giovanni ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c Laboratory for Pathophysiology of Orthopaedic Implants   (Italy)

Author keywords

Blood marker; Bone metastasis; MMP; MMP 2; Prognosis; Prostate cancer; TIMP; VCAM; VEGF

Indexed keywords

GELATINASE A; GELATINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR MARKER; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ADULT; AGED; ARTICLE; BONE METASTASIS; CANCER GROWTH; CANCER STAGING; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE FREE SURVIVAL; ENZYME LINKED IMMUNOSORBENT ASSAY; GLEASON SCORE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROSTATE ADENOCARCINOMA; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

ADENOCARCINOMA; AGED; DISEASE-FREE SURVIVAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PHENOTYPE; PILOT PROJECTS; PROPORTIONAL HAZARDS MODELS; PROSTATECTOMY; PROSTATIC NEOPLASMS; RISK ASSESSMENT; TIME FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; VASCULAR CELL ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 43449086399     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/156800908784293613     Document Type: Article

References (22)

1. Gronberg, H. Prostate cancer epidemiology. Lancet 2003, 361, 859-864.
2. Delongchamps, N. B.; Peyromaure, M.; Dinh-Xuan, A. T. Role of vascular endothelial growth factor in prostate cancer. Urology 2006, 68, 244-248.
3. Banks, R. E.; Gearing, A. J. H.; Hemingway, I. K.; Norfolk, D. R.; Perren, T. J.; Selby, P. J. Circulating intercellular adhesion molecule-1 (ICAM-1). E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies. Br. J. Cancer 1993, 68, 122-124.
4. Kageshita, T.; Yoshii, A.; Kimura, T.; Kuriya, N.; Ono, T.; Tsujisaki, M.; Imai, K.; Ferrone, S. Clinical relevance of ICAM-1 expression in primary lesions and serum of patients with malignant melanoma. Cancer Res. 1993, 53, 4927-4932.
5. Kim, S. H.; Cho, N. H.; Kim, K.; Lee, J.S.; Koo, B. S.; Kim, J. H.; Chang, J. H.; Chioi, E. C. Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. J. Surg. Oncol. 2006, 93, 330-337.
6. Khoddami, S. M.; Shariat, S. F.; Lotan, Y.; Saboorian, H.; McConnell, J. D.; Sagalowsky, A. I.; Roehrborn, C. G.; Koeneman, K. S. Predictive value of primary Gleason pattern 4 in patients with Gleason score 7 tumours treated with radical prostatectomy. BJU Int. 2004, 94, 42-46.
7. Shariat, S. F.; Anwuri, V. A.; Lamb, D. J.; Shah, N. V.; Wheeler, T. M.; Slawin, K. M. Association of preoperative plasma levels of vascular endothelial growth factor and soluble vascular cell adhesion molecule-1 with lymph node status and biochemical progression after radical prostatectomy. J. Clin. Oncol. 2004, 22, 1655-1663.
8. Masterson, T. A.; Bianco, F. J., Jr.; Vickers, A. J.; DiBlasio, C. J.; Fearn, P. A.; Rabbani, F.; Eastham, J. A.; Scardino, P. T. The association between total and positive lymph node counts, and disease progression in clinically localized prostate cancer. J. Urol. 2006, 175(4), 1320-1324.
9. Rogers, C. G.; Khan, M. A.; Craig Miller, M.; Veltri, R. W.; Partin, A. W. Natural history of disease progression in patients who fail to achieve an undetectable prostate-specific antigen level after undergoing radical prostatectomy. Cancer 2004, 101, 2549-2556.
10. Palapattu, G. S.; Allaf, M. E.; Trock, B. J.; Epstein, J. I.; Walsh, P. C. Prostate specific antigen progression in men with lymph node metastases following radical prostatectomy: results of long-term followup. J. Urol. 2004, 172, 1860-1864.
11. Gonzalez, C. M.; Roehl, K. A.; Antenor, J. V.; Blunt, L. W.; Han, M.; Catalona, W. J. Preoperative PSA level significantly associated with interval to biochemical progression after radical retropubic prostatectomy. Urology 2004, 64, 723-728.
12. Brayton, J.; Qing, Z.; Hart, M. N.; VanGilder, J. C.; Fabry, Z. Influence of adhesion molecule expression by human brain microvessel endothelium on cancer cell adhesion. J. Neuroimmunol. 1998, 89, 104-112.
13. Byrne, G. J.; Ghellal, A.; Iddon, J.; Blann, A. D.; Venizelos, V.; Kumar, S.; Howell, A.; Bundred, N. J. Serum soluble vascular cell adhesion molecule-1: role as a surrogate marker of angiogenesis. J. Natl. Cancer Inst. 2000, 92, 1329-1336.
14. Wu, T. C. The role of vascular cell adhesion molecule-1 in tumor immune evasion. Cancer Res. 2007, 67, 6003-6006.
15. Chung, T. W.; Lee, Y. C.; Kim, C. H. Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J. 2004, 18, 1123-1125.
16. Di, G. H.; Lu, J. S.; Song, C. G.; Li, H. C.; Shen, Z. Z.; Shao, Z. M. Over expression of aromatase protein is highly related to MMPs levels in human breast carcinomas. J. Exp. Clin. Cancer Res. 2005, 24, 601-607.
17. Ellem, S. J.; Schmitt, J. F.; Pedersen, J. S.; Frydenberg, M.; Risbridger, G. P. Local aromatase expression in human prostate is altered in malignancy. Clin. Endocrinol. Metab. 2004, 89, 2434-2441.
18. Akhtar, M.; Calder, M. R.; Corina, D. L.; Wright, J. N. Mechanistic studies on C-19 demethylation in oestrogen biosynthesis. Biochem. J. 1982, 201, 569-580.
19. Fishman, J.; Goto, J. Mechanism of estrogen biosynthesis. Participation of multiple enzyme sites in placental aromatase hydroxylations. J. Biol. Chem. 1981, 256, 4466-4471.
20. Simpson, E. R.; Mahendroo, M. S.; Nichols, J. E.; Bulun, S. E. Aromatase gene expression in adipose tissue: relationship to breast cancer. Int. J. Fertil. Menopausal. Stud. 1994, 39, 75-83.
21. Waas, E. T.; Wobbes, T.; Ruers, T.; Lomme, R. M.; Hendriks, T. Circulating gelatinases and tissue inhibitor of metalloproteinase-1 in colorectal cancer metastatic liver disease. Eur. J. Surg. Oncol. 2006, 32, 756-763.
22. Stephenson, A. J.; Scardino, P. T.; Eastham, J. A.; Bianco, F. J., Jr.; Dotan, Z. A.; Fearn, P. A.; Kattan, M. W. Preoperative nomogram predicting the 10-year probability of prostate cancer recurrence after radical prostatectomy. J. Natl. Cancer Inst. 2006, 98, 715-717.