Major histocompatibility complex class-I presentation impaired in transgenic mice expressing hepatitis C virus structural proteins during dendritic cell maturation

Journal of Medical Virology

Volumn 74, Issue 2, 2004, Pages 253-261

  Hiasa, Yoichi ^a,b   Takahashi, Hidemi ^c   Shimizu, Masumi ^c   Nuriya, Hideko ^a   Tsukiyama Kohara, Kyoko ^a   Tanaka, Takeshi ^d   Horiike, Norio ^b   Onji, Morikazu ^b   Kohara, Michinori ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

^d TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

Author keywords

Adenovirus vector; DC; HCV; Maturation; MHC

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NUCLEOTIDE; STRUCTURAL PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW; CELL ISOLATION; CELL LINEAGE; CELL MATURATION; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; FOUNDER EFFECT; HEPATITIS C VIRUS; IMMUNE ESCAPE; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOSURVEILLANCE; LIVER CELL; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PERSISTENT VIRUS INFECTION; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; TUMOR ESCAPE; VIRUS INFECTION; VIRUS MORPHOLOGY;

ADENOVIRIDAE; ANIMALS; ANTIGEN PRESENTATION; CELL DIFFERENTIATION; DENDRITIC CELLS; FLOW CYTOMETRY; GENETIC VECTORS; HEPACIVIRUS; HEPATITIS C; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; TRANSGENES; VIRAL STRUCTURAL PROTEINS;

ADENOVIRIDAE; HEPATITIS C VIRUS; MUS MUSCULUS;

EID: 4344718806     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.20164     Document Type: Article

References (37)

1. Akiyama K, Yokota K, Kagawa S, Shimbara N, Tamura T, Akioka H, Nothwang HG, Noda C, Tanaka T, Ichihara A. 1994. cDNA cloning and interferon gamma down-regulation of proteosomal subunits X and Y. Science 265:1231-1234.
2. Alter MJ. 1997. Epidemiology of hepatitis C. Hepatology 26:62S-65S.
3. Auffermann-Gretzinger S, Keeffe EB, Levy S. 2001. Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood 97:3171-3176.
4. Bain C, Fatmi A, Zoulim F, Zarski JP, Trepo C, Inchauspe G. 2001. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology 120:512-524.
5. Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature 392:245-252.
6. Cooper S, Erickson AL, Adams EJ, Kansopon J, Weiner AJ, Chien DY, Houghton M, Parham P, Walker CM. 1999. Analysis of a successful immune response against hepatitis C virus. Immunity 10:439-449.
7. Dolganiuc A, Kodys K, Kopasz A, Marshall C, Do T, Romics L, Jr., Mandrekar P, Zapp M, Szabo G. 2003. Hepatitis C virus core and nonstructural protein 3 proteins induce pro-and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol 170:5615-5624.
8. Gardner JP, Durso RJ, Arrigale RR, Donovan GP, Maddon PJ, Dragic T, Olson WC. 2003. L-SIGN is a liver-specific capture receptor for hepatitis C virus. Proc Natl Acad Sci USA 100:4498-4503.
9. Goutagny N, Fatmi A, Ledinghen HD, Penin F, Couzigou P, Inchauspe G, Bain C. 2003. Evidence of viral replication in circulating dendritic cells during hepatitis C virus infection. J Infect Dis 187:1951-1958.
10. Hiasa Y, Horiike N, Akbar SMF, Saito I, Miyamura T, Matsuura Y, Onji M. 1998. Low stimulatory capacity of lymphoid dendritic cells expressing hepatitis C virus genes. Biochem Biophys Res Commun 249:90-95.
11. Hiroishi K, Kita H, Kojima M, Okamoto H, Moriyama T, Kaneko T, Ishikawa T, Ohnishi S, Aikawa T, Tanaka N, Yazaki Y, Mitamura K, Imawari M. 1997. Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection. Hepatology 25:705-712.
12. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, Muramatsu S, Steinman RM. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulation factor. J Exp Med 176:1693-1702.
13. Kanegae Y, Lee G, Sato Y, Tanaka M, Nakai M, Sakaki T, Sugano S, Saito I. 1995. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res 23:3816-3821.
14. Kanto T, Hayashi N, Takehara T, Tatsumi T, Kuzushita N, Ito A, Sasaki Y, Kasahara A, Hori M. 1999. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol 162:5584-5591.
15. Kashiwakuma T, Hasegawa A, Kajita T, Takata A, Mori H, Ohta Y, Tanaka E, Kiyosawa K, Tanaka T, Tanaka S, Hattori N, Kohara M. 1996. Detection of hepatitis C virus specific core protein in serum of patients by a sensitive fluorescence enzyme immunoassay (FEIA). J Immunol Methods 190:79-89.
16. Kerkau T, Bacik I, Bennink JR, Yewdell JW, Hunig T, Schimpl A, Schubert U. 1997. The human immunodeficiency virus type 1 (HIV-1) Vpu protein interferes with an easy step in the biosynthesis of major histocompatibility complex (MHC) class I molecules. J Exp Med 185:1295-1305.
17. Koziel MJ, Dudley D, Wong JT, Dienstag J, Houghton M, Ralston R, Walker BD. 1992. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol 15:3339-3344.
18. Koziel MJ, Dudley D, Afdhal N, Choo QL, Houghton M, Ralston R, Walker BD. 1993. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol 67:7522-7532.
19. Longman RS, Talal AH, Jacobson IM, Albert ML, Rice CM. 2004. Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood 103:1026-1029.
20. Lozach PY, Lortat-Jacob H, de Lacroix de Lavalette A, Staropoli I, Foung S, Amara A, Houles C, Fieschi F, Schwartz O, Virelizier JL, Arenzana-Seisdedos F, Altmeyer R. 2003. DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. J Biol Chem 278:20358-20366.
21. Miyake S, Makimura M, Kanegae Y, Harada S, Sato Y, Takamori K, Tokuda C, Saito I. 1996. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci USA 93:1320-1324.
22. Moradpour D, Gradscheid B, Kammer AR, Schmidtke G, Groettrup M, Blum HE, Cerny A. 2001. Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro. Hepatology 33:1282-1287.
23. Nelson DR, Marousis CG, Davis GL, Rice CM, Wong J, Houghton M, Lau JY. 1997. The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C. J Immunol 158:1473-1481.
24. Niwa H, Yamamura K, Miyazaki J. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108: 193-200.
25. Pohlmann S, Zhang J, Baribaud F, Chen Z, Leslie GJ, Lin G, Granelli-Piperno A, Doms RW, Rice CM, McKeating JA. 2003. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J Virol 77:4070-4080.
26. Rollier C, Drexhage JAR, Verstrepen BE, Verschoor EJ, Bontrop RE, Koopman G, Heeney JL. 2003. Chronic hepatitis C virus infection established and maintained in chimpanzees independent of dendritic cell impairment. Hepatology 38:851-858.
27. Romani N, Gruner S, Brang D, Kampgen E, Lenz A, Trockenbacher B, Konwalinka G, Fritsch PO, Steinman RM, Schuler G. 1994. Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83-93.
28. Satto I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanabe Y, Koi S, Onji M, Ohta Y, Choo QL, Houghton M, Kuo G. 1990. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci USA 87:6547-6549.
29. Sarobe P, Lasarte JJ, Casares N, Lopez-Diaz de Cerio A, Baixeras E, Labarga P, Garcia N, Borras-Cuesta F, Prieto J. 2002. Abnormal priming of CD4+ T cells by dendritic cells expressing hepatitis C virus core and E1 proteins. J Virol 76:5062-5070.
30. Sarobe P, Lasarte JJ, Zabaleta A, Arribillaga L, Arina A, Melero I, Borras-Cuesta F, Prieto J. 2003. Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune response. J Virol 77:10862-10871.
31. Steinman RM. 1991. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271-296.
32. + class I MHC molecule-restricted murine CTLs in transgenic mice expressing the HCV structural genes. Biochem Biophys Res Commun 301:330-337.
33. Tanaka T, Lau JY, Mizokami M, Orito E, Tanaka E, Kiyosawa K, Yasui K, Ohta Y, Hasegawa A, Tanaka S, Kohara M. 1995. Simple fluorescent enzyme immunoassay for detection and quantification of hepatitis C viremia. J Hepatol 23:742-745.
34. Wakita T, Taya C, Katsume A, Kato J, Yonekawa H, Kanegae Y, Saito I, Hayashi Y, Koike M, Kohara M. 1998. Efficient conditional transgene expression in hepatitis C virus cDNA transgenic mice mediated by Cre/loxP system. J Biol Chem 273:9001-9006.
35. Wakita T, Katsume A, Kato J, Choji T, Yonekawa H, Kanegae Y, Saito I, Hayashi Y, Koike M, Miyamoto M, Hiasa Y, Kohara M. 2000. Possible role of cytotoxic T cells in acute liver injury in hepatitis C virus cDNA transgenic mice mediated by Cre/loxP system. J Med Virol 62:308-317.
36. Wedemeyer H, He XS, Nascimbeni M, Davis AR, Greenberg HB, Hoofnagle JH, Liang TJ, Alter H, Rehermann B. 2002. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol 169:3447-3458.
37. Wold WS, Gooding LR. 1989. Adenovirus E3 proteins that prevent cytolysis by cytotoxic T cells and tumor necrotic factor. Mol Biol Med 6:433-452.