Myosin heavy chain isoforms expression and cyclic AMP concentrations in hypoxia-induced hypertrophied right ventricle in rats

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

Volumn 138, Issue 4, 2004, Pages 365-370

  Hashimoto, Takeshi ^a   Sugiyama, Atsushi ^b   Taguchi, Sadayoshi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Adenylyl cyclase; Cardiac hypertrophy; High altitude; Hypobaric hypoxia; MHC ; Phosphodiesterase; Right ventricle; Sympathetic activity

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; MYOSIN HEAVY CHAIN; PHOSPHODIESTERASE;

ALTITUDE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEA LEVEL;

EID: 4344707202     PISSN: 10964959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpc.2004.04.018     Document Type: Article

References (21)

1. Baar K., Blough E., Dineen B., Esser K. Transcriptional regulation in response to exercise. Exerc. Sport Sci. Rev. 27:1999;285-315
2. Bernstein D., Voss E., Huang S., Doshi R., Crane C. Differential regulation of right and left ventricular β-adrenergic receptors in newborn lambs with experimental cyanotic heart disease. Mol. Cell. Biochem. 85:1990;68-74
3. Gupta M.P., Gupta M., Dizon E., Zak R. Sympathetic control of cardiac myosin heavy chain gene expression. Mol. Cell. Biochem. 157:1996;117-124
4. Gupta M.P., Kogut P., Gupta M. Protein kinase-A dependent phosphorylation of transcription enhancer factor-1 represses its DNA-binding activity but enhances its gene activation ability. Nucleic Acids Res. 28:2000;3168-3177
5. Hashimoto T., Yamasaki S., Taguchi S. Alterations in the expression of myosin heavy chain isoforms in hypoxia-induced hypertrophied ventricles in rats. Comp. Biochem. Physiol., B. 136:2003;139-145
6. Kacimi R., Richalet J.-P., Corsin A., Abousahl I., Crozatier B. Hypoxia-induced downregulation of β-adrenergic receptors in rat heart. J. Appl. Physiol. 73:1992;1377-1382
7. Kariya K., Karns L.R., Simpson P.C. An enhancer core element mediates stimulation of the rat beta-myosin heavy chain promoter by an alpha 1-adrenergic agonist and activated beta-protein kinase C in hypertrophy of cardiac myocytes. J. Biol. Chem. 269:1994;3775-3782
8. León-Velarde F., Bourin M.-C., Germack R., Mohammadi K., Crozatier B., Richalet J.-P. Differential alterations in cardiac adrenergic signaling in chronic hypoxia or norepinephrine infusion. Am. J. Physiol. 280:2001;R274-R281
9. Morano I., Adler K., Weismann K., Knorr A., Erdmann E., Bohm M. Correlation of myosin heavy chain expression in the rat with cAMP in different models of hypertension-induced cardiac hypertrophy. J. Mol. Cell. Cardiol. 25:1993;387-394
10. Morkin E. Control of cardiac myosin heavy chain gene expression. Microsc. Res. Tech. 50:2000;522-531
11. Newsholme E.A., Start C. Regulation of glycogen metabolism. Newsholme E.A., Start C. Regulation in Metabolism. 1973;146-194 Wiley, England
12. Sα and adenylyl cyclase cause β-adrenoceptor desensitization in chronically hypoxic rat hearts. Am. J. Physiol. 279:2000;C1455-C1463
13. Pinsky D., Oz M., Liano H., Morris S., Brett J., Sciacca R., Karakurum M., Van Lookeren Campagne M., Platt J., Nowygrod R., Koga S., Stern D. Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model. J. Clin. Invest. 92:1993;2994-3002
14. Razeghi P., Essop M.F., Huss J.M., Abbasi S., Manga N., Taegtmeyer H. Hypoxia-induced switches of myosin heavy chain iso-gene expression in rat heart. Biochem. Biophys. Res. Commun. 303:2003;1024-1027
15. Saegusa Y., Sugiyama A., Hashimoto K. Utilization of special absorption for measurement of adenylate cyclase activity. J. Clin. Lab. Anal. 14:2000;115-119
16. Sawada N., Sugiyama A., Kashiwagi K., Takahara S., Hashimoto K. Measurement of adenylate cyclase activity in the minute bovine ciliary epithelial cells during the pharmacological stimulation of adrenergic and cholinergic receptors. J. Clin. Lab. Anal. 13:1999;90-94
17. Sethi R., Dhalla K.S., Beamish R.E., Dhalla N.S. Differential changes in left and right ventricular adenylyl cyclase activities in congestive heart failure. Am. J. Physiol. 272:1997;H884-H893
18. Sugiyama A., Saegusa Y., Takahara A., Sugita M., Hashimoto K. Effects of sildenafil (ViagraTM) on cyclic AMP hydrolyzing phosphodiesterase activity in the canine heart assessed using a modified enzymatic fluorometric assay technique. Yamanashi Med. J. 17:2002;69-74
19. Sugiyama A., Takeuchi N., Saegusa Y., Sugita M., Hashimoto K. Molecular mechanisms of cardiostimulatory effects of sildenafil. Jpn. J. Pharmacol. 88:2002;362-364
20. Wright C.E., Bodell P.W., Haddad F., Qin A.X., Baldwin K.M. In vivo regulation of β-myosin heavy chain gene in hypertensive rodent heart. Am. J. Physiol. 280:2001;C1262-C1276
21. Yamazaki T., Komuro I., Yazaki Y. Role of the renin-angiotensin system in cardiac hypertrophy. Am. J. Cardiol. 83:1999;53H-57H