Depletion of Schistosoma mansoni lung-stage schistosomula cholesterol by methyl-β-cyclodextrin dramatically increases specific antibody binding to surface membrane antigens

Journal of Parasitology

Volumn 90, Issue 4, 2004, Pages 727-732

  El Ridi, Rashika ^a   Tallima, Hatem ^a   Mohamed, Shadia H ^a,b   Montash, Mona ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b Ain Shams University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISERUM; CHOLESTEROL; MEMBRANE ANTIGEN; METHYL BETA CYCLODEXTRIN; OLIGOSACCHARIDE; PARASITE ANTIBODY; PARASITE ANTIGEN; SCHISTOSOMA VACCINE;

ANTIBODY;

ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; IMMUNOFLUORESCENCE TEST; LARVA; LUNG; MALE; NONHUMAN; SCHISTOSOMA MANSONI; SCHISTOSOMULUM; SERUM; SYRIAN HAMSTER;

ABSORPTION; ANIMALS; ANTIBODIES, HELMINTH; ANTIBODY SPECIFICITY; ANTIGENS, HELMINTH; ANTIGENS, SURFACE; BETA-CYCLODEXTRINS; BINDING SITES, ANTIBODY; CHOLESTEROL; CRICETINAE; CYCLODEXTRINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; LARVA; LUNG; MALE; MESOCRICETUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; SCHISTOSOMA MANSONI;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS; SCHISTOSOMA; SCHISTOSOMA MANSONI; TREMATODA;

EID: 4344702850     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.1645/GE-3334     Document Type: Article

References (35)

1. BICKLE, Q. D., AND M. J. FORD. 1982. Studies on the surface antigenicity and susceptibility to antibody-dependent killing of developing schistosomula using sera from chronically infected mice and mice vaccinated with irradiated cercariae. Journal of Immunology 128: 2101-2106.
2. BILLECOCQ, A. 1987. Protection by phospholipids of Schistosoma mansoni schistosomula against the action of cytotoxic antibodies and complement. Molecular and Biochemical Parasitology 25: 133-142.
3. COULSON, P. S. 1997. The radiation-attenuated vaccine against schistosomes in animal models: Paradigm for a human vaccine? Advances in Parasitology 39: 271-336.
4. CURWEN, R. S., AND R. A. WILSON. 2003. Invasion of skin by schistosome cercariae: Some neglected facts. Trends in Parasitology 19: 63-66.
5. CURTIS, J., R. E. SORENSEN, AND D. J. MINCHELLA. 2002. Schistosome genetic diversity: The implications of population structure as detected with microsatellite markers. Parasitology 125(Suppl.): S51-S59.
6. DALTON, J. P., M. STRAND, B. L. MANGOLD, AND D. A. DEAN. 1986. Identification of Schistosoma mansoni glycoproteins recognized by protective antibodies from mice immunized with irradiated ceracriae. Journal of Immunology 136: 4689-4694.
7. DEAN, D. A. 1977. Decreased binding of cytotoxic antibody by developing Schistosoma mansoni. Evidence for a surface change independent of host antigen adsorption and membrane turnover. Journal of Parasitology 63: 418-426.
8. -, AND B. L. MANGOLD. 1992. Evidence that both normal and immune elimination of Schistosoma mansoni take place at the lung stage of migration prior to parasite death. American Journal of Tropical Medicine and Hygiene 47: 238-248.
9. DESSEIN, A., J. C. SAMUELSON, A. E. BUTTERWORTH, M. HOGAN, B. A. SHERRY, M. A. VADAS, AND J. R. DAVID. 1981. Immune evasion by Schistosoma mansoni: Loss of susceptibility to antibody or complement-dependent eosinophil attack by schistosomula cultured in medium free of macromolecules. Parasitology 82: 357-374.
10. DUNNE, D., AND A. MOUNTFORD. 2001. Resistance to infection in humans and animal models. In Schistosomiasis, A. A. F. Mahmoud (ed.). Imperial College Press, London, U.K., p. 133-212.
11. EL GENGEHI, N., R. EL RIDI, N. ABDEL TAWAB, M. EL DEMELLAWY, AND B. L. MANGOLD. 2000. A Schistosoma mansoni 62-kDa band is identified as an irradiated vaccine T-cell antigen and characterized as calreticulin. Journal of Parasitology 86: 993-1000.
12. EL RIDI, R. 2002. Toward a complete immunity-inducing vaccine for schistosomiasis. Journal of Parasitology 88: 1049-1050.
13. -, S. H. MOHAMED, AND H. TALLIMA. 2003. Incubation of Schistosoma mansoni lung-stage schistosomula in corn oil exposes their surface membrane antigenic specificities. Journal of Parasitology 89: 1064-1067.
14. ENGELS, D., L. CHITSULO, A. MONTRESOR, AND L. SAVIOLI. 2002. The global epidemiological situation of schistosomiasis and new approaches to control and research. Acta Tropica 82: 139-146.
15. GEBEL, H. M., J. W. OLDFATHER, R. W. KARR, T. C. FULLER, AND G. E. RODEY. 1984. Antibodies directed against HLA-DR gene products exhibit the CYNAP phenomenon. Tissue Antigens 23: 135-140.
16. GROSSMAN, H. B. 1983. Hybridoma antibodies reactive with human bladder carcinoma cell surface antigens. Journal of Urology 130: 610-614.
17. KILSDONK, E. P. C., P. G. YANCEY, G. W. STOUDT, F. W. BANGERTER, W. J. JOHNSON, M. C. PHILLIPS, AND G. H. ROTHBLAT. 1995. Cellular cholesterol efflux mediated by cyclodextrins. Journal of Biological Chemistry 270: 17250-17256.
18. KUSEL, J. R., AND J. F. GORDON. 1989. Biophysical studies of the schistosome surface and their relevance to its properties under immune and drug attack. Parasite Immunology 11: 431-451.
19. LANGLEY, J. G., AND D. W. DUNNE. 1992. Temporal variation in the carbohydrate and peptide surface epitopes in antibody-dependent, eosinophil-mediated killing of Schistosoma mansoni schistosomula. Parasite Immunology 14: 185-200.
20. LAZDINS, J. K., M. J. STEIN, J. R. DAVID, AND A. SHER. 1982. Schistosoma mansoni: Rapid isolation and purification of schistosomula of different developmental stages by centrifugation on discontinuous density gradients of Percoll. Experimental Parasitology 53: 39-44.
21. LUBLIN, D. M., AND F. C. GRUMET. 1982. Mechanisms of the CYNAP phenomenon: Evidence in the Bw49/Bw50 model for epitopes with different spatial orientation of antibody. Human Immunology 4: 137-145.
22. MCLAREN, D. J. 1989. Will the real target of immunity to schistosomiasis please stand up? Parasitology Today 5: 279-282.
23. MINCHELLA, D. J., K. M. SOLLENBERGER, AND C. PEREIRA DE SOUZA. 1995. Distribution of schistosome genetic diversity within molluscan intermediate hosts. Parasitology 111: 217-220.
24. MORROW, M. R., D. SINGH, D. LU, AND C. W. M. GRANT. 1995. Glycosphingolipid fatty acid arrangement in phospholipid bilayers: Cholesterol effects. Biophysics Journal 68: 179-186.
25. NEUFELD, E. B., A. M. COONEY, J. PITHA, E. A. DAWIDOWICZ, N. K. DWYER, P. G. PENTCHEV, AND E. J. BLANCHETTE-MACKIE. 1996. Intracellular trafficking of cholesterol monitored with a cyclodextrin. Journal of Biological Chemistry 271: 21604-21613.
26. OSMAN, A., R. EL RIDI, N. GUIRGUIS, AND D. A. DEAN. 1994. Identification of Schistosoma mansoni antigens recognized by spleen cells of C57B1/6 mice immunized with ultraviolet-irradiated cercariae. International Journal for Parasitology 24: 943-950.
27. PEARCE, E. J., P. F. BASCH, AND A. SHER. 1986. Evidence that the reduced surface antigenicity of developing Schistosoma mansoni schistosomula is due to antigen shedding rather than host molecule acquisition. Parasite Immunology 8: 79-94.
28. RICHTER, D., AND D. A. HARN. 1993. Candidate vaccine antigens identified by antibodies from mice vaccinated with 15- or 50-kilorad-irradiated cercariae of Schistosoma mansoni. Infection and Immunity 61: 146-154.
29. SAMUELSON, J. C., A. SHER, AND J. P. CAULFIELD. 1980. Newly transformed schistosomula spontaneously lose surface antigens and C3 acceptor sites during culture. Journal of Immunology 124: 2055-2057.
30. SHER, A., AND D. BENNO. 1982. Decreasing immunogenicity of developing schistosome larvae. Parasite Immunology 4: 101-107.
31. SINGH, M., R. SHARMA, AND U. C. BANERJEE. 2002. Biotechnological applications of cyclodextrins. Biotechnology Advances 20: 341-359.
32. SIRE, C., P. DURAND, J. P. POINTIER, AND A. THERON. 2001. Genetic diversity of Schistosoma mansoni within and among individual hosts (Rattus rattus): Infrapopulation differentiation at microspatial scale. International Journal for Parasitology 31: 1609-1616.
33. STURROCK, R. F. 2001. The schistosomes and their intermediate hosts. In Schistosomiasis, A. A. F. Mahmoud (ed.). Imperial College Press, London, U.K., p. 7-83.
34. WIEST, P. M., S. S. KUNZ, AND K. R. MILLER. 1994. Activation of protein kinase C by phorbol esters disrupts the tegument of Schistosoma mansoni. Parasitology 109: 461-468.
35. WILSON, R. A. 1987. Cercariae to liver worms: Development and migration in the mammalian host. In The biology of schistosomes from genes to latrines, D. Rollinson and A. J. G. Simpson (eds.). Academic Press, London, U.K., p. 116-146.