Longitudinal study on mutation profiles of core promoter and precore regions of the hepatitis B virus genome in children

Pediatric Research

Volumn 56, Issue 3, 2004, Pages 396-399

  Ni, Yen Hsuan ^a   Chang, Mei Hwei ^a   Hsu, Hong Yuan ^a   Tsuei, Daw Jen ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B(E) ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEROCONVERSION; VIRUS CARRIER; VIRUS GENOME;

EID: 4344702775     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000136282.20470.87     Document Type: Article

References (26)

1. Milich DR, Jones JE, Hughes JL, Price J, Raney AK, McLachlan A 1990 Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc Natl Acad Sci USA 87:6599-6603
2. Lee PI, Chang MH, Lee CY, Hsu HY, Chen PJ, Chen DS 1990 Changes of serum hepatitis B virus DNA and transaminase level in the natural course of chronic hepatitis B virus infection in children. Hepatology 12:657-660
3. Chang MH, Sung JL, Lee CY, Chen JS, Hsu HY, Lee PI, Chen DS 1989 Factors affecting the clearance of hepatitis B e antigen in hepatitis surface antigen carrier children. J Pediatr 115:385-390
4. Carman WF, Ferao M, Lok AS, Ma OC, Lai CL, Thomas HC 1992 Precore sequence variation in Chinese isolates of hepatitis B virus. J Infect Dis 165:127-133
5. Takeda K, Akahane Y, Suzuki H, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M 1990 Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy. Hepatology 12:1284-1289
6. Feitelson M 1994 Biology of hepatitis B virus variants. Lab Invest 71:324-349
7. Nguyen XT, Fukuda R, Fukumoto S 1994 Precore region mutation in hepatitis B virus genome in early stage of infection: a study in hepatitis B e antigen-positive young carriers. J Gastroenterol 29:469-473
8. Bortolotti F, Crivellaro C, Brunetto MR, Cadrobbi P, Bertolini A, Alberti A 1993 Selection of a precore mutant of hepatitis B virus and reactivation of chronic hepatitis B acquired in childhood. J Pediatr 123:583-585
9. Chang MH, Hsu HY, Ni YH, Tsai KS, Lee PI, Chen PJ, Hsu YL, Chen DS 1998 Precore stop codon mutant in chronic hepatitis B virus infection in children: its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen. J Hepatol 28:915-922
10. Okamoto H, Tsuda F, Akahane Y, Sugai Y, Yoshiba M, Moriyama K, Tanaka T, Miyakawa Y, Mayumi M 1994 Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 68:8102-8110
11. Yuh CH, Chang YL, Ting LP 1992 Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virus. J Virol 66:4073-4084
12. Moriyama K, Okamoto H, Tsuda F, Mayumi M 1996 Reduced precore transcription and enhanced core-pregenomic transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections. Virology 226:269-280
13. Buckwold VE, Xu Z, Chen M, Yen TS, Ou JH 1996 Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 70:5845-5851
14. Barbera C, Calvo P, Coscia A, Perugini L, Dastoli G, Randone A, Bonino F, Brunetto MR 1994 Precore mutant hepatitis B virus and outcome of chronic infection and hepatitis in hepatitis B e antigen-positive children. Pediatr Res 36:347-350
15. Friedt M, Gerner P, Lausch E, Trübel H, Zabel B, Wirth S 1999 Mutations in the basic core promoter and the precore region of hepatitis B virus and their selection in children with fulminant and chronic hepatitis B. Hepatology 29:1252-1258
16. Hsu HY, Chang MH, Lee CY, Hsieh KH, Ni YH, Chen PJ, Chen DS 1995 Precore mutant of hepatitis B virus in childhood fulminant hepatitis B: an infrequent association. J Infect Dis 71:776-781
17. Kwok S, Higuchi S 1989 Avoiding the false positive with PCR. Nature 339:237-238
18. Naito H, Hayashi S, Abe K 2001 Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers. J Clin Microbiol 39:362-364
19. Lindh M, Anderson AS, Gusdal A 1997 Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus-large scale analysis using a new genotyping method. J Infect Dis 175:1285-1293
20. Honda A, Yokosuka O, Ehata T, Tagawa M, Imazeki F, Saisho H 1999 Detection of mutations in the enhancer 2/core promoter region of hepatitis B virus in patients with chronic hepatitis B virus infection: comparison with mutations in precore and core region in relation to clinical status. J Med Virol 57:337-344
21. Yuen MF, Sablon E, Yuan HJ, Wong DK, Hui CK, Wong BC, Chan AO, Lai CL 2003 Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma. Hepatology 37:562-567
22. Parekh S, Zoulim F, Ahn SH, Tsai A, Li J, Kawai S, Khan N, Trépo C, Wands J, Tong S 2003 Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants. J Virol 77:6601-6612
23. Günther S, Piwon N, Iwanska A, Schilling R, Meisel H, Will H 1996 Type, prevalence, and significance of core promoter/enhancer II mutations in hepatitis B virus from immunosuppressed patients with severe liver disease. J Virol 70:8318-8331
24. Kidd-Ljunggren K, Öberg M, Kidd AH 1997 Hepatitis B virus X gene 1751 to 1764 mutations: implications for HBeAg status and disease. J Gen Virol 78:1469-1478
25. Kao JH, Chen PJ, Lai MY, Chen DS 2000 Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 118:554-559
26. Chan HL, Hussain M, Lok AS 1999 Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore region during hepatitis B e antigen seroconversion. Hepatology 29:976-984