Equipment review: The molecular adsorbents recirculating system (MARS®)

Critical Care

Volumn 8, Issue 4, 2004, Pages 280-286

  Boyle, Martin ^a   Kurtovic, Jelica ^a   Bihari, David ^a   Riordan, Stephen ^a   Steiner, Christian ^b,c  

^a PRINCE OF WALES HOSPITAL   (Australia)

^b Teraklin AG   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Artificial liver; Liver failure; Toxins

Indexed keywords

ALBUMIN; AROMATIC AMINO ACID; BILE ACID; BILIRUBIN; FATTY ACID; NITRIC OXIDE; TOXIN; TRYPTOPHAN;

ALBUMIN DIALYSIS; CHRONIC LIVER DISEASE; CLINICAL STUDY; COST EFFECTIVENESS ANALYSIS; DETOXIFICATION; DIALYSIS; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE SEVERITY; EXPERIENCE; HEMODYNAMICS; HUMAN; LIVER CELL DAMAGE; LIVER DYSFUNCTION; LIVER FAILURE; MEDICAL INSTRUMENTATION; MULTIPLE ORGAN FAILURE; OUTCOMES RESEARCH; PATHOGENESIS; PATIENT SELECTION; PRIORITY JOURNAL; REVIEW; SEPSIS; SURVIVAL; SURVIVAL RATE; TIME; TREATMENT OUTCOME;

HUMANS; LIVER FAILURE, ACUTE; LIVER, ARTIFICIAL; SERUM ALBUMIN; SORPTION DETOXIFICATION; TECHNOLOGY ASSESSMENT, BIOMEDICAL;

EID: 4344699867     PISSN: 13648535     EISSN: None     Source Type: Journal    
DOI: 10.1186/cc2895     Document Type: Review

References (32)

1. Mitzner SR, Stange J, Klammt S, Peszynski P, Schmidt R, Noldge-Schlomburg G: Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure. J Am Soc Nephrol 2001, 12:S75-S82.
2. Mitzner S, Loock J, Peszynski P, Klammt S, Majcher-Peszynska J, Gramowski A, Stange J, Schmidt R: Improvement in central nervous system functions during treatment of liver failure with albumin dialysis MARS-a review of clinical, biochemical, and electrophysiological date. Metabolic Brain Dis 2002, 17:463-475.
3. Schmidt LE, Sorensen VR, Svendsen LB, Hansen BA, Larsen FS: Hemodynamic changes during a single treatment with the molecular adsorbents recirculating system in patients with acute-on-chronic liver failure. Liver Transpl 2001, 7:1034-1039.
4. Schmidt LE, Wang LP, Hansen BA, Larsen FS: Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial. Liver Transpl 2003, 9:290-297.
5. Heemann U, Treichel U, Loock J, Philipp T, Gerken G, Malago M, Klammt S, Loehr M, Liebe S, Mitzner S, Schmidt R, Stange J: Albumin dialysis in cirrhosis with superimposed acute liver injury; a prospective, controlled study. Hepatology 2002, 36: 949-958.
6. Mitzner SR, Stange J, Klammt S, Risler T, Erley CM, Bader BD, Berger ED, Lauchart W, Peszynski P, Freyrag J, Hickstein H, Loock J, Lõhr J-M, Liebe S, Emmrich J, Korten G, Schmidt R: Improvement of hepatorenal syndrome with extracorporeal albumin dialysis MARS; results of a prospective, randomised, controlled clinical trial. Liver Transpl 2000, 6:277-286.
7. Sen S, Mookerjee RP, Davies NA, Williams R, Jalan R: Review article: the Molecular Adsorbents Recirculating System (MARS) in liver failure. Aliment Pharmacol Ther 2002, 16 (Suppl 5):32-38.
8. Sen S, Jalan R, Williams R: Liver failure: basis of benefit of therapy with the molecular adsorbents recirculating system. Int J Biochem Cell Biol 2003, 35:1306-1311.
9. Steiner C, Mitzner S: Experiences with MARS liver support therapy in liver failure: analysis of 176 patients of the International MARS Registry. Liver 2002, 22(Suppl 2):20-25.
10. Heim T: 5th international symposium on albumin dialysis [insert]. Intensive Care Med 2003, 29(11):1.
11. Steiner C, Majacher-Peszynska J, Peszynski P, Teasdale D: MARS® Liver Support Therapy. Therapy Information for Doctors and Nurses. Edition 1.2, Teraklin AG; April 2002.
12. Stange J, Mitzner S: A carrier-mediated transport of toxins in a hybrid membrane. Safety barrier between a patients blood and a bioartificial liver. Int J Artif Organs 1996, 19:677-691.
13. Stange J, Mitzner SR, Risler T Erley CM, Lauchart W, Goehl H, Klammt S, Peszynski P, Freytag J, Hickstein H, Lohr M, Liebe S, Schareck WP, Hopt UT, Schmidt R: Molecular adsorbent recycling system (MARS): Clinical results of a new membrane-based blood purification system for bioartificial liver support Artif Organs 1999, 23:319-330.
14. McIntyre CW, Fluck RJ, Freeman JG, Lambie SH: Characterization of treatment dose delivered by albumin dialysis in the treatment of acute renal failure associated with severe hepatic dysfunction. Clin Nephrol 2002, 58:376-383.
15. Evenepoel P, Maes B, Wilmer A, Nevens F, Fevery J, Kuypers, Bammens B, Vanrenterghem Y: Detoxifying capacity and kinetics of the molecular adsorbent recycling system. Contribution of the different inbuilt filters. Blood Purif 2003, 21:244-252.
16. Sorkine P, Ron Ben A, Szold O, Biderman P, Kidron A, Merchav H, Brill S, Oren R: Role of the molecular adsorbent recycling system (MARS) in the treatment of patients with acute exacerbation of chronic liver failure. Crit Care Med 2001, 29:1332-1336.
17. Schneider T, Klammt S, Mitzner S. Detoxifying capacity of MARS®: membrane transport and adsorption columns are effective over entire intermittent treatment period [abstract]. In Book of Abstracts, 5th International Symposium an albumin dialysis in liver disease: 2003 September 5-7; Rostock University of Rostock Department of Medicine; 2003:61.
18. Klammt S, Brinkmann B, Mitzner S, Munzert E, Loock J, Stange J, Emmrich J, Liebe S: Albumin binding capacity (AbiC) is reduced in commercially available human serum albumin preparations with stabilizers. Z Gastrenterol 2001, 39:24-27.
19. Emerson TE: The unique features of albumin: a brief review. Crit Care Med 1989, 17:690-694.
20. Riordan SM, Williams R: Acute liver failure: targeted artificial and hepatocyte-based support of liver regeneration and reversal of multiorgan failure. J Hepatol 2000, 32 (Suppl 1):63-76.
21. Mullhaupt B, Kullak-Ublick GA, Ambuehl P, Maggiorini M, Stocker R, Kadry Z, Claven PA, Renner EL: First clinical experience with molecular adsorbents recirculating system (MARS®) in six patients with severe acute on chronic liver failure. Liver 2002, 22 (Suppl 2 ):59-62.
22. Guo Li-Min, Liu J-Y, Xu D-Z, Li B-S, Han H, Wang L-H, Zhang W-Y, Lu L-H, Guo X, Sun F-X, Zhang H-Y, Liu X-D, Zhang J-P, Yao Y, He Z-P, Wang M-M: Application of molecular adsorbents recirculating system to remove NO and cytokines in severe liver failure patients with multiple organ dysfunction syndrome. Liver Int 2003, 23 (Suppl 3):16-20.
23. Catlina M-V, Barrio J, Anaya F, Salcedo M, Rincon D, Clemente G, Banares R: Hepatic and systemic haemodynamic changes after MARS in patients with acute on chronic liver failure. Liver Int 2003, 23 (Suppl 3):39-43.
24. Contreras J, Poniachik J, Oksenberg D, Valera JM, Cotera A, Pacheco A, Segovia E, sanheuza ME, Rojas J, Mancilla C, Guerrero J, Toledo C, Mena S, Diaz JC: MARS® therapy improves grade IV hepatic encephalopathy in acute liver failure prior to liver transplantation. The first case experience in Chile. In Book of Abstracts, 5th International Symposium on albumin dialysis in liver disease: 2003 September 5-7; Rostock. University of Rostock Department of Medicine; 2003:15.
25. Pares A: Utility of albumin dialysis in the treatment of cholestaic pruritis. In Book of Abstracts, 5th International Symposium on albumin dialysis in liver disease: 2003 September 5-7; Rostock. University of Rostock Department of Medicine; 2003:45.
26. Hoeckerstedt K, Koivusalo A-M, Vakkuri A, Lindgren L, Blomster M, Isoniemi H: MARS® treatment in acute liver failure. In Book of Abstracts, 5th International Symposium on albumin dialysis in liver disease: 2003 September 5-7; Rostock. University of Rostock Department of Medicine; 2003:25.
27. Huang J, Li L, Chen Y: Perioperative application of artificial liver support system in orthotopic liver transplantation. In Book of Abstracts, 5th International Symposium on albumin dialysis in liver disease: 2003 September 5-7; Rostock. University of Rostock Department of Medicine; 2003:27.
28. Liu Y-H, Wang Y, Yu Li-X, Sun L-Y, Feng B-L, Shen Z-Y, Wang M-M: Artificial liver support MARS therapy as a bridge to retransplantation in two cases on long anhepatic duration. In Book of Abstracts, 5th International Symposium on albumin dialysis in liver disease: 2003 September 5-7; Rostock. University of Rostock Department of Medicine; 2003:35.
29. Koivusalo AM, Yildirim Y, Vakkuri A, Lindgren L, Hoekerstedt K, Isoniemi H: Experience with albumin dialysis in five patients with severe overdoses of paracetamol. Acta Anaesthesiol Scand 2003, 47:1145-1150.
30. Faybik P, Hetz H, Baker A, Bittermann C, Berlakovich G, Werba A, Krenn C-G, Steltzer H: Extracorporeal albumin dialysis in patients with Amanita phalloides poisoning. Liver Int 2003, 23 (Suppl 3):28-33.
31. van de Kerkhove M-P, de Jong KP, Rijken AM, de Pont A-C JM, van Gulik TM: MARS treatment in posthepatectomy. liver failure. Liver Int 2003, 23 (Suppl 3):44-51.
32. Kellersmann R, Gassel H-J, Buehler C, Thiede A, Timmermann W: Application of molecular adsorbents recirculating system® in patients with severe liver failure after hepatic resection or transplantation: intial single-centre experiences. Liver 2002, 22(Suppl 2):56-58.