Meiotic defects in a man with non-obstructive azoospermia: Case report

Human Reproduction

Volumn 19, Issue 8, 2004, Pages 1770-1773

  Sun, F ^a,b   Kozak, G ^c   Scott, S ^a   Trpkov, K ^c   Ko, E ^b   Mikhaail Philips, M ^a,b   Bestor, T H ^d   Moens, P ^e   Martin, R H ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b ALBERTA CHILDREN'S HOSPITAL   (Canada)

^c Rockyview Hospital   (Canada)

^d Columbia University ^*  (United States)

^e YORK UNIVERSITY   (Canada)

Author keywords

Male infertility; Meiotic recombination; Non obstructive azoospermia; Pachytene spermatocytes; Synaptonemal complex analysis

Indexed keywords

PROTEIN ANTIBODY; PROTEIN MLH1;

ADULT; ARTICLE; AUTOSOME; AZOOSPERMIA; CASE REPORT; CENTROMERE; CYTOGENETICS; GENE LOCUS; GENETIC PROCEDURES; GENETIC RECOMBINATION; HUMAN; IMMUNOGENETICS; MALE; MALE INFERTILITY; MEIOSIS; PACHYTENE; PROPHASE; SYNAPTONEMAL COMPLEX;

EID: 4344654289     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deh335     Document Type: Article

References (16)

1. Aboulghar H, Aboulghar M, Manour R, Serour G, Amin Y and Al-Inany H (2001) A prospective controlled study of karyotyping for 430 consecutive babies conceived through intracytoplasmic sperm injection. Fertil Steril 76,249-254.
2. Anderson LK, Reeves A, Webb LM and Ashley T (1999) Distribution of crossing over on mouse synaptonemal complexes using immunofluorescent localization of MLH1 protein. Genetics 151,1569-1579.
3. Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A et al. (1996) Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet 13,336-342.
4. Barlow AL and Hultén MA (1998) Crossing over analysis at pachytene in man. Eur J Hum Genet 6,350-358.
5. Bascom-Slack C, Ross L and Dawson D (1997) Chiasmata, crossovers, and meiotic chromosome segregation. Adv Hum Genet 35,253-283.
6. Bourc'his D, Xu G-L, Lin C-S, Bollman B and Bestor TH (2001) Dnmt3L and the establishment of maternal genomic imprints. Science 294, 2536-2539.
7. Egozcue J, Templado C, Vidal F, Navarro J, Morer-Fargas F and Marina S (1983) Meiotic studies in a series of 1100 infertile and sterile males. Hum Genet 65,185-188.
8. Hultén M, Eliasson R and Tillinger KG (1970) Low chiasma count and other meiotic irregularities in two infertile 46, XY men with spermatogenic arrest. Hereditas 65,285-290.
9. Hunt P and Hassold T (2002) Sex matters in meiosis. Science 296, 2181-2183.
10. Johnson M (1998) Genetic risks of intracytoplasmic sperm injection in the treatment of male infertility: recommendations for genetic counseling and screening. Fertil Steril 70,397-411.
11. Lynn A, Koehler KE, Judis L, Chan ER, Cherry JP, Schwartz S, Seftel A, Hunt P and Hassold TJ (2002) Covariation of synaptonemal complex length and mammalian meiotic exchange rates. Science 296,2222-2225.
12. Marcon E and Moens P (2003) MLH1p and MLH3p localize to precociously induced chiasmata of okadaic-acid-treated mouse spermatocytes. Genetics 165,2283-2287.
13. Martin R (1996) The risk of chromosomal abnormalities following ICSI. Hum Reprod 11,924-925.
14. Shi Q and Martin R (2001) Aneuploidy in human spermatozoa: FISH analysis in men with constitutional chromosomal abnormalities, and in infertile men. Reproduction 121,655-666.
15. Shi Q, Spriggs E, Field L, Ko E, Barclay L and Martin R (2001) Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human sperm. Am J Med Genet 99,34-38.
16. Van Steirteghem A, Bonduelle M, Devroey P and Liebaers I (2002) Follow-up of children born after ICSI. Hum Reprod Update 8,111-116.