Reproductive disorders in pubertal and adult phase of the male rats exposed to vinclozolin during puberty

Journal of Veterinary Medical Science

Volumn 66, Issue 7, 2004, Pages 847-853

  Yu, Wook Joon ^a   Lee, Beom Jun ^a   Nam, Sang Yoon ^a   Ahn, Byeongwoo ^a   Hong, Jin Tae ^a   Do, Jae Cheul ^b   Kim, Young Cheul ^c   Lee, Yong Soon ^d   Yun, Young Won ^a  

^a Chungbuk National University   (South Korea)

^b Gyeongbuk Veterinary Service Laboratory   (South Korea)

^c Keimyung University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Flutamide; Serum testosterone; Sperm count; Sperm motility; Vinclozolin

Indexed keywords

ANIMALIA; CAPUT;

ANTIANDROGEN; FLUTAMIDE; FUNGICIDE; METHYLTESTOSTERONE; OXAZOLE DERIVATIVE; TESTOSTERONE; VINCLOZOLIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; DRUG EFFECT; MALE; ORAL DRUG ADMINISTRATION; PATHOLOGY; PUBERTY; RAT; SEMINAL VESICLE; SPERMATOZOON; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SPRAGUE DAWLEY RAT; TESTIS;

ADMINISTRATION, ORAL; ANDROGEN ANTAGONISTS; ANIMALS; FLUTAMIDE; FUNGICIDES, INDUSTRIAL; MALE; METHYLTESTOSTERONE; OXAZOLES; PUBERTY; RATS; RATS, SPRAGUE-DAWLEY; SEMINAL VESICLES; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTIS; TESTOSTERONE;

EID: 4344651654     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.66.847     Document Type: Article

References (12)

1. Andrews, P., Freyberger, A., Hartmann, E., Eiben, R., Loof, I., Schmidt, U., Temerowski, M. and Becka, M. 2001. Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandrogenic drug flutamide. Arch. Toxicol. 75: 65-73.
2. Choi, G.J., Lee, H.J. and Cho, K.Y. 1996. Lipid peroxidation and membrane disruption by vinclozolin in dicarboximide-susceptible and -resistant isolates of Botrytis cinerea. Pestic. Biochem. Physiol. 55: 29-39.
3. Gray, L.E. Jr., Ostby, J. and Kelce, W. 1994. Development effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat. Toxicol. Appl. Pharmacol. 129: 46-52.
4. Kelce, W.R., Monosson, E., Gamcsik, M.P., Laws, S.C. and Gray, L.E. Jr. 1994. Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol. Appl. Pharmacol. 126: 276-285.
5. Marchetti, B. and Labrie, F. 1988. Characteristics of flutamide action on prostatic and testicular functions in the rat. J. Steroid. Biochem. 29: 691-698.
6. Meriggiola, M.C. and Bremner, W.J. 1997. Progestin-androgen combination regimens for male contraception. J. Androl. 18: 240-244.
7. Monosson, E., Kelce, W., Lambright, C., Ostby. J. and Gray, L.E. Jr. 1999. Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the male rat. Toxicol. Ind. Health 15: 65-79.
8. Moorman, W.J., Cheever, K.L., Skaggs, S.R., Clark, J.C., Turner, T.W., Marlow, K.L. and Schrader, S.M. 2000. Male adolescent exposure to endocrine-disrupting pesticides: vinclozolin exposure in peripubertal rabbits. Andrologia 32: 285-293.
9. O'Connor, J.C., Cook, J.C., Slone, T.W., Makovec, G.T., Frame, S.R. and Davis, L.G. 1998. An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs). Toxicol. Sci. 46: 45-60.
10. Rankin, G.O., Teets, V.J., Nicoll, D.W. and Brown, P.I. 1989. Comparative acute renal effects of three N-(3,5-dichlorophenyl)carboxide fungicides: N-(3,5-Dichlorophenyl)-scuccinimide, vinclozolin and iprodione. Toxicology 56: 263-272.
11. Russell, L.D., Malone, J.P. and Karpas, S.L. 1981. Morphological pattern elicited by agents affecting spermatogenesis by stimulation. Tissue Cell. 13: 369-380.
12. Wong, C., Kelce, W.R., Sar, M. and Wilson, E.M. 1995. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J. Biol. Chem. 270: 19998-20003.