Total body irradiation prior to bone marrow transplantation; some aspects of fifty year experience

Journal of B.U.ON.

Volumn 9, Issue 2, 2004, Pages 147-160

  Gocheva, Lilia ^a,b  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b NONE   (Bulgaria)

Author keywords

Bone marrow transplantation; Dose rate; Fractionation schedule; Radiobiological; Total body irradiation; Total dose

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOGENIC BONE MARROW TRANSPLANTATION; APLASTIC ANEMIA; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW TRANSPLANTATION; CANCER RECURRENCE; CATARACT; CATARACT EXTRACTION; CELL KILLING; CHRONIC GRANULOCYTIC LEUKEMIA; COMBINED IMMUNODEFICIENCY; DOSIMETRY; EXPERIENCE; GRAFT VERSUS HOST REACTION; HEALTH CARE FACILITY; HEMATOLOGIC DISEASE; HEMATOLOGIC MALIGNANCY; HODGKIN DISEASE; HUMAN; IMMUNE DEFICIENCY; INTERMETHOD COMPARISON; INTERSTITIAL PNEUMONIA; KIDNEY DISEASE; LEUKEMIA CELL; LUNG DISEASE; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; PATIENT CARE; PATIENT POSITIONING; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PRESCRIPTION; PROGNOSIS; RADIATION BEAM; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RADIATION ENERGY; RADIATION INJURY; RADIOBIOLOGY; RETROSPECTIVE STUDY; REVIEW; SPINAL CORD DISEASE; SURVIVAL; TREATMENT OUTCOME; WHOLE BODY RADIATION;

EID: 4344649765     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (118)

1. Hoffstetter S, Marchal C, Bordigoni P et al. Total body irradiation in France in the past twenty years. Cancer Radiother 2003; 7: 166-171.
2. Chaoul H, Lange K. Uber Lymphogranulomatose und ihre Behandlung mit Roentgenstrahlen. Munchener Med Wochenschrift 1923; 700: 725.
3. Jacobson LO, Marks EK, Robson MJ et al. Effect of spleen protection on mortality following X-irradiation. J Lab Clin Med 1949; 34: 1538-1543.
4. Lorenz E, Uphoff DE, Reid TR, Shelton E. Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst 195 1; 12: 197-201.
5. Webster FW. Physical considerations in the design of facilities for uniform whole body irradiation of man. Radiology 1960; 75: 19-33.
6. Lam WC, Order SE,Thomas, ED et al. Uniformity and standardization of single and opposing 60- Co sources for total body irradiation. Int J Radiat Oncol Biol Phys 1980; 6: 245-250.
7. Kolb HJ, Rider I, Bobenberger K, Netzel B et al. Dose rate and dose fractionation studies in total body irradiation of dogs. Pathol Biol 1979; 27: 370-372.
8. Surmont J, Dutreix A, LaLamme CM. Les irradiations in toto pour greffe de tissue on transplantation d organe chez l' homme. J Radiol Electrol 1960; 41: 679-689.
9. Cunningham JR, Wright DJ. A simple facility for whole-body irradiation. Radiology 1962; 78: 941-949.
10. Aget H, Van Dyk J, Leung MK. Utilization of a high energy photon beam for whole body irradiation. Radiology 1977; 123: 747-751.
11. Van Dyk J, Leung MK, Cunningham JR. Dosimetric consideration of very large cobalt- 60 fields. Int J Radiat Oncol Biol Phys 1980; 6: 753-759.
12. Leung MK, Rider WD, Webb HP et a]. Cobalt-60 therapy unit for large field irradiation. Int J Radiat Oncol Biol Phys 1981 7: 705-712.
13. Peters LJ, Withers HR, Gundiff JH et al. Radiobiological considerations in the use of total body irradiation for bone marrow transplantation. Radiology 1979; 131: 243-247.
14. Shank B, O'Reilly RJ, Cunninghan I et al. Total body irradiation for bone marrow transplantation: The Memorial Sloan-Kettering Cancer Center experience. Radiother Oncol 1990; 1: 68-81.
15. Santos GW. History of bone marrow transplantation. In: Nathan (ed): Clinics in Haernatology. Bone marrow transplantation (Vol 12). WB Saunders, London, Philadelphia, Toronto 1983, pp 611-639.
16. Cassileth PA, Anderson JW, Bennett JM et al. Escalating the intensity of post remission therapy improves the outcome in acute myeloid leukemia. The ECOG experience. Leukemia 1992; 6: 116-119.
17. Kim TH, McGlave PB, Ramsay N et al. Comparison of two total body irradiation regimens in allogeneic bone marrow transplantation for acute non-lymphoblastic leukemia in first remission. Int J Radiat Biol Oncol Phys 1990; 19: 889-897.
18. Attal M, Harousseau JL, Stoppa AM et al. A prospective randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. N Engl J Med 1996; 335: 91-97.
19. Philip T, Gugliemi C, Hagenbeck A et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. N Engl J Med 1995; 333: 1540-1545.
20. Thomas ED. Total body irradiation regimens for marrow grafting. Int J Radiat Oncol Biol Phys 1990; 19:1285-1288.
21. Cosset JM, Sosie G, Dubray B. Single dose versus fractionated total body irradiation before bone marrow transplantation: Radiobiological and clinical considerations. Int J Radiat Oncol Biol Phys 1994; 30: 477-496.
22. Clift RA, Buckner CD, Thomas ED. Allogeneic marrow transplantation using fractionated total body irradiation in patients with acute lymphoblastic leukemia in relapse. Leuk Res 1992; 6:401-407.
23. Vriesendorp HM, Van Bekkum DW. Role of total body irradiation in conditioning for bone marrow transplantation In: Thierfelder S, Rodt H, Kolb H (eds): Immunobiology of bone marrow transplantation. Springer Verlag, Berlin, 1980, pp 349-365.
24. Vriesendorp, HM, Order SE. Hodgkin's disease: new possibilities for clinical research. Int J Radiat Oncol Biol Phys 1989; 17: 1119-1121.
25. D'Angio GJ. Meeting of Orlando, 1982. Symposium on magna-field irradiation: rationale, technique, results. Int J Radiat Oncol Biol Phys 1982; 9:1905-1974.
26. Barrett A. Systemic radiotherapy. In: Steel GG, Adams GE, Peckham NJ (eds): The biological basis of radiotherapy. Elsevier, Amsterdam-New York-Oxford. 1983, pp 243-259.
27. Van Beuningen D. Some radiobiological aspects of total body irradiation. Strahlenther Oncol 1986; 162: 223-225.
28. Dutreix J, Gluckman E, Brule DM. Biological problems of total body irradiation. J Eur Radiother 1982; 3: 165-173.
29. Song CW, Kim TH, Khan FM, Kersey JH, Levitt SH. Radiobiological basis of total body irradiation with different dose rates and fractionation: repair capacity of hemopoietic sells. Int J Radiat Oncol Biol Phys 1981;7: 1695-1701.
30. Barrett A, Deledge MH, Powless RL. Interstitial pneumonitis following bone marrow transplantation after low dose rate total body irradiation. Int J Radiat Oncol Biol Phys 1983;9: 1029-1033.
31. Lopez-Cardozo B, Zoetelief H, Van Bekkum DW, Zurcher C, Hagenbeek A. Lung damage following bone marrow transplantation. The contribution of irradiation. Int J Radiat Oncol Biol Phys 1985; 11: 907-914.
32. Molls M, Budach V, Bambarg M. Total body irradiation: the lung as critical organ. Strahlenther Oncol 1986; 162: 226-232.
33. Keane TJ, Van Dyk J, Rider WD. Idiopathic interstitial pneumonia following bone marrow transplantation: The relationship with total body irradiation. Int J Radiat Oncol Biol Phys 1981; 7: 1365-1370.
34. Van Houtte M. Radiation and chemotherapy induced lung toxicity. Int J Radiat Oncol Biol Phys 1987; 13: 647-640.
35. Quast U. Total body irradiation - review of treatment techniques in Europe, Radiother Oncol 1987; 9: 91-106.
36. Quast U, Szy D. The relevant physical parameters of total body irradiation. A review. Radiobiol Radiother 1988; 2:282-294.
37. Van Dyk J, Galvin JM, Glasgow GP, Podgorsak E. The physical aspects of total and half body photon irradiation. AAPM report 17, 1987.
38. Gopal R, Ha CS, Tucher SL et al. Comparison of two total body irradiation fractionation regimens with respect to acute and late pulmonary toxicity. Cancer 2001; 92: 1949-1958.
39. Corvo R, Paoli G, Barra S et al. Total body irradiation correlates with chronic graft versus host disease and affects prognosis of patients with acute lymphoblastic leukemia receiving an HLA identical allogeneic bone marrow-transplant. Int J Radiat Oncol Biol Phys 1999; 43: 497-503.
40. Miralbell R, Rouzaud M, Grob E et al. Can a total body irradiation technique be fast and reproducible? Int J Radiat Oncol Biol Phys 1991; 29:1167-1173.
41. Alleti P. Summary of the discussion on lung shielding. J Eur Radiother 1982; 4: 255-256.
42. Rosenbloom M. Summary of the discussion on homogeneity of dose distribution. J Eur Radiother 1982; 4: 252-254.
43. Quast U. Dosimetry of total body irradiation. A review, methods and considerations. In: Dosimetry in radiotherapy. IAEA, Vienna, pp 188-210.
44. Podgorsak EB, Pla C, Evans M, Pla M. The influence of phantom size on output, peak scatter factor, and percentage depth dose in large-field photon irradiation. Med Phys 1985; 12: 639-645.
45. Trott KR, Holler M, Kolb HJ. Strahlenbiologische Uberlegungen zur Weiterent wicklung der Ganzkorperbestrahlung bei der Behandlung akuter Leukaemien mit auschliessender Knochen-marktransplantation. Strahenther Onkol 198 1; 157: 537-541.
46. Peters LJ, Withers HR, Cundiff JH, Dicke KA. Radiobiological considerations in the use of total body irradiation forbone marrow transplantation. Radiology 1979; 113: 243-247.
47. Dutreix J, Gluckman E, Brule DM. Biological problems of total body irradiation. J Eur Radiother 1982; 3: 165-173.
48. Clift RA, Buckner CD, Appelbaum FR et al. Allogeneic marrow transplantation in patients with acute myeloid leukemia in the first remission: A randomized trial of two irradiation regimens. Blood 1990; 76:1867-1871.
49. Clift RA, Buckner CD, Appelbaum FR et al. Allogeneic marrow transplantation in patients with chronic myeloid leukemia in the chronic phase; A randomized trial of two irradiation regimens. Blood 1991; 77: 1660-1665.
50. Vriesendorp HM, Herman MG, Saral R. Future analyses of total body irradiation. Int J Radiat Oncol Biol Phys 1991; 20: 635-637.
51. Gale RP, Butturini A, Bortin MM. What does total body irradiation do in bone marrow transplants for leukemia? Int J Radiat Oncol Biol Phys 1991; 20: 629-632.
52. Weiner RS, Bortin MM, Gale RP et al. Interstitial pneumonitis after bone marrow transplantation. Assessment of risk factors. Ann Intern Med 1986; 104: 168-175.
53. Keane TJ, Van Dyk J. TBI schedules prior to bone marrow transplantation; requirements for composition. Radiother Oncol 1989; 15: 207-209.
54. Broerce JJ, Dutreix A, Noordijk EM. Physical, biological and clinical aspects of total body irradiation. Proc ESTRO, EULEP and EBMT TBI - Meeting, The Haag, 1988. Radiother Oncol 1990; 18 (Suppl 1): S1 - S162.
55. Down HJ, Tarbell NJ, Thames HD et al. Syngeneic and allogeneic bone marrow entgraftment after total body irradiation: Dependence on dose, dose rate and fractionation. Blood 1991; 77: 661-669.
56. Spitzer TR, McAfee SL, Powell S. Dose escalated total body irradiation (TBI) and autologous peripheral blood stem cell transplantation (PBSCT) for refractory hematologic malignancy (HM). Blood 1996; 88: 8b (abstr).
57. Pape H. Knochenmarktramsplantation: Die Rolle der Strahlentherapie. Schweiz Rundsch Med Prax 1996; 85: 749-752.
58. Passweg JR, Tiberghien P, Cahn JY et al. Graft versus leukemia effects in T lineage and B lineage acute lymphoblastic leukemia. Bone Marrow Transplant 1998; 21: 153-158.
59. Vitale V, Corvo R, Franzone P et al. Allogeneic marrow transplantation in patients with acute and chronic myeloid leukemia. Influence of total body irradiation dose and graft versus disease in relapse rate. Bull Cancer/Radiother 1991; 78: 207-216.
60. Bieri S, Helg C, Chapnis B, Miralbell R. Total body irradiation before allogeneic bone marrow transplantation: is more dose better? Int J Radiat Oncol Biol Phys 2001; 49: 1071-1077.
61. Socie G, Veum Stone J, Wingard JR et al. Long term survival and late deaths after allogeneic bone marrow transplantation. N Engl J Med 1999; 43: 14-21.
62. Fowler JF. The linear quadratic formula and progress in fractionated radiotherapy. Br Radiat 1989; 62: 679-694.
63. Evans RG. Biologic and physical principles of total body irradiation for allogencic and autologous bone marrow transplantation in children with leukemia and lymphoma. In: Cassady JR (eds): Radiation therapy in pediatric oncology. New York: Springer - Verlag, 1994, pp 115-121.
64. Van Bekkum DW, Hagenbeek A. Immunohematological aspects of total body irradiation and bone marrow transplantation for the treatment of leukemia. Radiother Oncol 1990; 1: 28-36.
65. Vrisendorp HM, Johnson PM, Fey TA et al. Optimal dose of total body irradiation for allogeneic bone marrow transplantation. Transplant Proc 1985; 17: 583.
66. Frassoni F, Scarpati D, Bacigalupo A et al. The effect of total body irradiation dose and chronic graft versus host disease of leukemic relapse after allogencic bone marrow transplantation. Br Haematol 1989; 73: 211-216.
67. Frassoni F, Sessarego M, Bacigalupo A. Competition between recipient and donor cells after total bone marrow transplantation for chronic myeloid leukemia. Br J Haematol 1992; 9: 471-475.
68. Fowler JF, Travis EL. The radiation pneumonitis syndrome in half body radiation therapy. Int J Radiat Oncol Biol Phys 1978; 4: 1111 -1113.
69. Socie G, Devergie A, Girinsky T et al. Influence of fractionation of total body irradiation on complications and relapse rate for chronic myelogeneous leukemia. Int J Radiat Oncol Biol Phys 1991; 20: 397-404.
70. Miralbell R, Bieri S, Mermillod B et al. Renal toxicity after allogeneic bone marrow transplantation: the combined effect of total body irradiation and graft-versus-host disease. J Clin Oncol 1996; 14:579-585.
71. Benyunes MC, Sullivan KM, Deeg HJ et al. Cataracts after bone marrow transplantation: Long-term follow-up of adults treated with fractionated total body irradiation. Int J Radiat Oncol Biol Phys 1995; 32: 661-670.
72. Lohr F, Wenz F, Schraube P. Lethal pulmonary toxicity after autologous bone marrow transplantation /peripheral blood stem cell transplantation for hematological malignancies. Radiother Oncol 1998; 48: 45-51.
73. Farag SS, Elder PJ, Marcucci G et al. Radiation-free regimens result in similar outcomes of allogeneic hematopoietic progenitor cell transplantation in patients aged e″50 years compared to younger adults with low-risk disease. Bone Marrow Transplant 2003; 31: 87-93.
74. Villela L, Sureda A, Canals C et al. Low transplant related mortality in older patients with hematologic malignancies undergoing autologous stem cell transplantation. Haematologica 2003; 88: 300-305.
75. Frassoni F, Labopin M, Powels R et al. Effect of centre on outcome of bone marrow transplantation for acute myeloid leukemia. Lancet 2000; 355: 1393-1398.
76. Quast U(ed). Dose to lung. Proc DGMP-TBI-working group meeting, University of Essen, 1990, pp 1-270.
77. Lehnert S. Response of the lung to intermittent irradiation: importance of average versus instantaneous dose rate. Int J Radiat Oncol Biol Phys 1985; 11: 2183-2184.
78. Travis EL, Peters LJ, McNeill J et al. Effect of dose rate on total body irradiation lethality and pathologic findings. Radiother Oncol 1985; 4: 341-351.
79. Peters L, Travis EL. The radiobiology of total body irradiation. Proc ESTRO 1987, 121 (abstr).
80. Dewey WC, Ling CC, Meyn RE. Radiation-induced apoptosis: Relevance to radiotherapy. Int J Radiat Oncol Biol Phys 1995; 33: 781-796.
81. Ozsahin M, Pene F, Touboul E. Total body irradiation before bone marrow transplantation. Results of two randomized instantaneous dose rates in 157 patients. Cancer 1992 ; 69: 2853-2865.
82. Down JD, Tarbell NJ, Thames HD et al. Syngeneic and allogeneic. Dependence on dose, dose rate, and fractionation. Blood 1991; 76: 151-157.
83. Song CW, Kim TH, Khan FM et al. Radiobiological basis of total body irradiation with different dose rate and fractionation repair capacity of hemopoietic cells. Int J Radiat Oncol Biol Phys 1995; 33: 781-796.
84. Gogna NK, Morgan G, Downs K et al. Lung dose rate and interstitial pneumonitis in total body irradiation for bone marrow transplantation. Australas-Radiol 1992; 36: 317-320.
85. Barrett A, Nicholls J, Gibson B. Late effects of total body irradiation. Radiother Oncol 1987; 9: 131-135.
86. Bray LC, Carey PJ, Proctor SJ et al. Ocular complications of bone marrow transplantation. Br J Ophthalmol 1991; 75: 611-614.
87. Belkacemi Y, Pene F, Touboul E et al. Total body irradiation before bone marrow transplantation for acute leukemia in first or second complete remission. Results and prognostic factor in 326 consecutive patients. Strahlenther Oncol 1998; 174: 92-104.
88. Tichelli A. Late ocular complications after bone marrow transplantation. Nouv Rev Fr Hematol 1994; 36:79-82.
89. Belkacemi Y, Labopin M, Vernant JP et al. Cataracts after total body irradiation and bone marrow transplantation in patients with acute leukemia in complete remission. A study of the European group for blood and bone marrow transplantation. Int J Radiat Oncol Biol Phys 1998; 41: 659-668.
90. Belkacemi Y, Labopin M, Vernant JP et al. Cataract incidence after total body irradiation (TBI) and bone marrow transplantation (BMT) for acute leukemia (AL) in complete remission (CR). An EBMT study. Bone Marrow Transplant 1992; 19 (Suppl 1):S78 (abstr).
91. Ozsahin M, Belkacemi Y, Pene F et al. Total body irradiation and cataract incidence: a randomized comparison of two instantaneous dose rates. Int J Radiat Oncol Biol Phys 1994; 28: 343-347.
92. Ozsahin M, Pene F, Touboul E et al. Total body irradiation before bone marrow transplantation. Cancer 1992; 69: 2853-2865.
93. Zierhut D, Lohr F, Schraube P et al. Cataract incidence after total body irradiation. Int J Radiat Oncol Biol Phys 2000: 46: 131-135.
94. Belkacemi Y, Ozsahin M, Pene F et al. Cataractogenesis after total body irradiation. Int J Radiat Oncol Biol Phys 1996; 35: 53-60.
95. Glasgow GP. The dosimetry of fixed, single source hemibody and total body irradiation. Med Phys 1982; 9: 311-322.
96. Dutriex A, Wambersie A, Lonette M et al. Total body irradiation technique and dosimetry. Pathol Biol 1979; 27:273-278.
97. Lehnert S, Aybuka B, Suissa S, Giambatisto D. Radiation response of hematopoietic cell lines of human origin. Int J Radiat Oncol Biol Phys 1986; 49: 423-431.
98. Uckun FM, Song CW. Radiobiological features of fresh leukemic bone marrow progenitor cells in acute lymphoblastic leucemia. Cancer Res 1989; 48: 5788-5795.
99. Cosset JM, Girinsky T, Socie G. The never-ending controversy about TBI schedules. Radiother Oncol 1992: 23: 268.
100. Turesson L. Radiobiological aspects of continuous low dose rate irradiation and fractionated high dose rate irradiation. Radiother Oncol 1990; 19: 1-16.
101. Cosset JM, Socie G, Dubray B et al. Single dose versus fractionated total body irradiation before bone marrow transplantation: radiobiological and clinical considerations. Int J Radiat Oncol Biol Phys 1994; 30: 477-492.
102. Shank B, Hopfan S, Kim H et al. Hyperfractionated total body irradiation for bone marrow transplantation. Early results in leukemia patients; 22nd Ann Meet Am Soc Ther Radiol, Dallas, Texas, 1980.
103. Deeg HJ, Sullivan KM, Buckner CD et al. Marrow transplantation for acute nonlymphoblastic leukemia in first remission: Toxicity and long-term follow-up of patients conditioned with single dose or fractionated total body irradiation. Bone Marrow Transplant 1986; 1: 151-157.
104. Cosset JM, Girinsky T, Malaise EP et al. Clinical basis for TBI fractionation. Radiother Oncol 1990; 1: 60-67.
105. Slavin S, Or R, Weshler Z, Hale G et al. The use of total lymphoid irradiation for abrogation of host resistance to T cell depleted marrow allografts. Bone Marrow Transplant 1986; 1: 98.
106. Iriondo A, Hermosa V, Richard C et al. Graft rejection following T lymphocyte depleted bone marrow transplantation with two different TBI regimens. Br J Haematol 1987; 65: 246-248.
107. Poynton CH, MacDonalds, Byrom NA et al. Rejection after T cell depletion of donor bone marrow. Bone Marrow Transplant 1987; 2 (Suppl 1): 153.
108. Ganem G, Guentz M, Beaujeau F et al. Additional total lymphoid irradiation (TLI) in preventing graft failure of T cell depleted bone marrow transplantation (BMT) fromHLA identical siblings: Results of a prospective randomized study. Bone Marrow Transplant 1987; 2 (Suppl 1): 156.
109. Lohr F, Wenz F, Schraube P et al. Lethal pulmonary toxicity after bone marrow transplantation/peripheral blood stem cell transplantation for hematological malignancies. Radiother Oncol 1988; 48: 45-51.
110. Wara W, Pillips T, Margolis L et al. Radiation pneumonitis: A new approach to the deviation of time dose factors. Cancer 1973; 32: 547-552.
111. Thomas ED, Clift RA, Hersman J et al. Marrow transplantation for acute nonlymphoblastic leucemia in first remission using fractionated or single dose irradiation. Int J Radiat Oncol Biol Phys 1982; 8: 817-821.
112. Vriesendorp HM. Radiobiological speculations on therapeutic total body irradiation. Crit Rev Oncol 1990; 10:211-224.
113. Vriesendorp HM. Predictions of effects of therapeutic total body irradiation in man. Radiother Oncol 1990; 1: 37-50.
114. Tait RC, Burnett AK, Robertson AG et al. Subclinical pulmonary function defects following autologous and allogeneic bone marrow transplantation: relationship to total body irradiation and graft-versus-host disease. Int J Radiat Oncol Biol Phys 1991; 20: 1219-1227.
115. Wenz F, Steinvorth S, Lohr F et al. Prospective evaluation of delayed central nervous system (CNS) toxicity of hyperfractionated total body irradiation. Int J Radiat Oncol Biol Phys 2000; 48: 1497-1501.
116. Alvegard T. Transplantation of bone marrow and peripheral stem cells. Acta Oncol 1996; 35: 137-140.
117. Quast U. Problems of dose modification in total body irradiation. Strahlenther Oncol 1986; 162: 271-275.
118. Peper M, Steinvorth S, Schraube P et al. Neurobehavioral toxicity of total body irradiation: a follow-up in long-term survivors. Int J Radiat Oncol Biol Phys 2000;46: 303-311. bone marrow entgraftment after total body irradiation: