Efficacy and safety of simvastatin in Asian and non-Asian coronary heart disease patients: A comparison of the GOALLS and STATT studies

Current Medical Research and Opinion

Volumn 20, Issue 8, 2004, Pages 1235-1243

  Morales, Dante ^a   Chung, Namsik ^b   Zhu, Jun Ren ^c   Sangwatanaroj, Somkiat ^d   Yin, Wei Hsien ^e   Lee, Kathy ^f   Davies, Michael J ^g   Shah, Arvind ^g   Loeys, Tom ^g   Bilheimer, David ^g  

^a Manila Doctor's Hospital   (Philippines)

^b Yonsei University College of Medicine   (South Korea)

^c FUDAN UNIVERSITY   (China)

^d KING CHULALONGKORN MEMORIAL HOSPITAL   (Thailand)

^e CHENG HSIN REHABILITATION MEDICAL CENTER   (Taiwan)

^f UNIVERSITY OF HONG KONG   (Hong Kong)

^g MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Asian; Coronary heart disease; GOALLS; LDL C; Statins; STATT

Indexed keywords

APOLIPOPROTEIN A1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN; STATINE DERIVATIVE; TRIACYLGLYCEROL;

ARTICLE; ASIAN; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; DIZZINESS; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ETHNOLOGY; HEALTH PROGRAM; HEPATITIS; HUMAN; ISCHEMIC HEART DISEASE; MEDICAL SOCIETY; MULTICENTER STUDY; MYOPATHY; OPEN STUDY; RHABDOMYOLYSIS; SIDE EFFECT; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 4344632127     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079904125004367     Document Type: Article

References (15)

1. Matsuzawa Y, Kita T, Mabuchi H, et al. Sustained reduction of serum cholesterol in low-dose 6-year simvastatin treatment with minimum side effects in 51 321 Japanese hypercholesterolemic patients. Circ J 2003;67:287-94
2. Wu CC, Sy R, Tanphaichitr V, Hin AT, Suyono S, Lee YT. Comparing the efficacy and safety of atorvastatin and simvastatin in Asians with elevated low-density lipoprotein-cholesterol - a multinational, multicenter, double-blind study. J Formos Med Assoc 2002;101:478-87
3. Kobayashi T, Homma Y. Effects of low-dose pravastatin on plasma levels of lipids and apolipoproteins in Japanese type II hyperlipoproteinemic subjects with apolipoprotein E phenotype E3/2, E3/3, and E4/3. J Clin Pharmacol 2001;41:1055-8
4. Garmendia F, Brown AS, Reiber I, Adams PC. Attaining United States and European guideline LDL-cholesterol levels with simvastatin in patients with coronary heart disease (the GOALLS study). Curr Med Res Opin 2000;16:208-19
5. Chung N, Cho SY, Choi DH, et al. STATT: a titrate-to-goal study of simvastatin in Asian patients with coronary heart disease. Simvastatin Treats Asians to Target. Clin Ther 2001;23:858-70
6. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). J Am Med Assoc 2001;285:2486-97
7. Wood D, De Backer G, Faergeman O, Graham I, Mancia G, Pyorala K. Prevention of coronary heart disease in clinical practice: recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention. Atherosclerosis 1998;140:199-270
8. Tan CE, Loh LM, Tai ES. Do Singapore patients require lower doses of statins? The SGH lipid clinic experience. Singapore Med J 2003;44:635-8
9. Dart A, Jerums G, Nicholson G, et al. A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients with hypercholesterolemia. Am J Cardiol 1997;80:39-44
10. Steinhagen-Thiessen E. Comparative efficacy and tolerability of 5 mg and 10 mg simvastatin and 10 mg pravastatin in moderate primary hypercholesterolemia [Simvastatin Pravastatin European Study Group]. Cardiology 1994;85:244-54
11. Zhou HH, Koshakji RP, Silberstein DJ, Wilkinson GR, Wood AJ. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites. New Engl J Med 1989;320:565-70
12. Muck W, Unger S, Kawano K, Ahr G. Inter-ethnic comparisons of the pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin. Br J Clin Pharmacol 1998;45:583-90
13. Chisholm A, Mann J, Sutherland W, Williams S, Ball M. Dietary management of patients with familial hypercholesterolaemia treated with simvastatin. Q J Med 1992;85:825-31
14. Clifton PM, Noakes M, Nestel PJ. Gender and diet interactions with simvastatin treatment. Atherosclerosis 1994;110:25-33
15. Poulter NR, Caulfield M, Feder G. Ethnic variations in response to a statin (EVIREST). J Hum Hypertens 2001;15(Suppl 1):S87-S89