Antiparkinsonian actions of a selective 5-HT1A agonist, tandospirone, in rats

Biogenic Amines

Volumn 18, Issue 3-6, 2004, Pages 329-338

  Ishibashi, Tadashi ^a   Ohno, Yukihiro ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

5 HT1A agonist; Catalepsy; L DOPA; Parkinson's disease; Rotation behavior; Tandosphirone

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ANTIPARKINSON AGENT; BENSERAZIDE; BROMOCRIPTINE; BUSPIRONE; DIAZEPAM; DOPAMINE 2 RECEPTOR BLOCKING AGENT; HALOPERIDOL; LEVODOPA; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; OXIDOPAMINE; PEROSPIRONE; RESERPINE; RITANSERIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; TANDOSPIRONE; ZIPRASIDONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; CIRCLING BEHAVIOR; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG MECHANISM; DRUG SELECTIVITY; LOCOMOTION; MALE; NERVOUS SYSTEM INJURY; NONHUMAN; PARKINSON DISEASE; PARKINSONISM; RAT;

PARKINSONIA;

EID: 4344615955     PISSN: 01688561     EISSN: None     Source Type: Journal    
DOI: 10.1163/1569391041501924     Document Type: Article

References (23)

1. Andersen, H. L. and Kilpatrick, I. C. (1996). Prevention by (±)-8-hydroxy-2-(di-n-propylamino) tetralin of both catalepsy and the rises in rat striatal dopamine metabolism caused by haloperidol, Br. J. Pharmacol. 118, 421-427.
2. Colpaert, F. C. (1987). Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat, Neuropharmacology 26, 1431-1440.
3. Costall, B., Naylor, R. J. and Pycock, C. (1976). Non-specific supersensitivity of striatal dopamine receptors after 6-hydroxydopamine lesion of the nigrostriatal pathway, Eur. J. Pharmacol. 35, 275-283.
4. Elliott, P. J., Close, S. P., Walsh, D. M., et al. (1990). Neuroleptic-induced catalepsy as a model of Parkinson's disease. I. Effect of dopaminergic agents, Neural Transm. Park. Dis. Dement. Sect. 2, 79-89.
5. 2 antagonistic actions, Jpn. J. Pharmacol. 53, 321-329.
6. Jolicoeur, F. B. and Rivest, R. (1992). Rodent models of Parkinson's disease, in: Neuromethods, Vol. 21: Animal Models of Neurological Disease I, Boulton, A., Baker, G. and Butterworth, R. (Eds), pp. 135-158. The Humana Press, New Jersey, USA.
7. Kobayashi, T., Araki, T., Itoyama, Y., et al. (1997). Effects of L-DOPA and bromocriptine on haloperidol-induced motor deficits in mice, Life Sci. 61, 2529-2538.
8. Lang, A. E. and Lozano, A. M. (1998). Parkinson's disease. First of two parts, New Engl. J. Med. 339, 1044-1053.
9. 2A/C antagonist, reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release, Psychopharmacology 131, 57-63.
10. Meltzer, H. Y. and Nash, J. F. (1991). Effects of antipsychotic drugs on serotonin receptors, J. Pharmacol. Exp. Ther. 295, 853-861.
11. Menza, A. M. and Mark, M. H. (1994). Parkinson's disease and depression: the relationship to disability and personality, J. Neuropsychiatry Clin. Neurosci. 6, 165-169.
12. Menza, A. M., Robertson-Hoffman, D. E. and Bonapace, A. S. (1993). Parkinson's disease and anxiety: comorbidity with depression, Biol. Psychiatry 34, 465-470.
13. 1A receptors, J. Pharmacol. Exp. Ther. 295, 853-861.
14. Neal-Beliveau, B. S., Joyce, J. N. and Lucki, I. (1993). Serotonergic involvement in haloperidol-induced catalepsy, J. Pharmacol. Exp. Ther. 265, 207-217.
15. 1A receptor agonist, tandospirone improves gait disturbance of patients with Parkinson's disease, J. Mov. Disord. Disability 7, 65-70.
16. Robertson, G. S., Fine, A. and Robertson, H. A. (1991). Dopaminergic grafts in the striatum reduce D1 but not D2 receptor-mediated rotation in 6-OHDA-lesioned rats, Brain Res. 539, 304-311.
17. 2 antagonist modulates the effects of D-2 dopamine receptor blockade, J. Pharmacol. Exp. Ther. 253, 1162-1170.
18. Shimizu, H., Hirose, A., Tatsuno, T., et al. (1987). Pharmacological properties of SM-3997: a new anxioselective anxiolytic candidate, Jpn. J. Pharmacol. 45, 493-500.
19. Shimizu, H., Karai, N., Hirose, A., et al. (1988). Interaction of SM-3997 with serotonin receptors in rat brain, Jpn. J. Pharmacol. 46, 311-314.
20. Shimizu, H., Kumasaka, Y., Tanaka, H., et al. (1992). Anticonflict action of tandospirone in a modified Geller-Seiffer conflict test in rats, Jpn. J. Pharmacol. 58, 283-289.
21. 2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition, Psychopharmacology 98, 45-50.
22. Ungerstedt, U. and Arbuthnott, G. W. (1970). Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system, Brain Res. 24, 485-493.
23. 1A autoreceptors by the local application of 8-OH-DPAT reverses raclopride-induced catalepsy in the rat, Neuropharmacology 34, 495-499.