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Jemal, A.1
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2
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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
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Hingorani SR, Petricoin EF, Maitra A, et al.: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003, 4:437-450. This paper describes a transgenic mouse model directed at pancreatic KRAS that spontaneously forms PanINs and eventually pancreatic cancer. This type of model could be used for preventive and therapeutic investigation.
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Hingorani, S.R.1
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Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreas
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Ammori JB, Colletti LM, Zalupski MM, et al.: Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreas. J Gastrointest Surg 2003, 7:766-772.
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Ammori, J.B.1
Colletti, L.M.2
Zalupski, M.M.3
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4
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0142048579
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An orthotopic nude mouse model for evaluating pathophysiology and therapy of pancreatic cancer
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Hotz HG, Reber HA, Hotz B, et al.: An orthotopic nude mouse model for evaluating pathophysiology and therapy of pancreatic cancer. Pancreas 2003, 26:e89-e98.
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Hotz, H.G.1
Reber, H.A.2
Hotz, B.3
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5
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0346217046
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Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression
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Buchler P, Reber HA, Buchler MW, et al.: Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression. Cancer 2004, 100:201-210.
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Buchler, P.1
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CEACAM6 as a novel target for indirect type 1 immunotoxin-based therapy in pancreatic adenocarcinoma
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Duxbury MS, Ito H, Ashley SW, et al.: CEACAM6 as a novel target for indirect type 1 immunotoxin-based therapy in pancreatic adenocarcinoma. Biochem Biophys Res Commun 2004, 317:837-843. This study demonstrated that the inhibition of CEACAM6 resulted in smaller tumors in vivo and made the cancer cells more susceptible to normal cellular death mechanisms.
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Biochem Biophys Res Commun
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Duxbury, M.S.1
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7
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Highly expressed genes in pancreatic ductal adenocarcinomas: A comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
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Iacobuzio-Donahue CA, Ashfaq R, Maitra A, et al.: Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 2003, 63:8614-8622.
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Iacobuzio-Donahue, C.A.1
Ashfaq, R.2
Maitra, A.3
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8
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Preoperative staging and tumor resectability assessment of pancreatic cancer: Prospective study comparing endoscopic ultrasonography, helical computed tomography, magnetic resonance imaging, and angiography
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Soriano A, Castells A, Ayuso C, et al.: Preoperative staging and tumor resectability assessment of pancreatic cancer: prospective study comparing endoscopic ultrasonography, helical computed tomography, magnetic resonance imaging, and angiography. Am J Gastroenterol 2004, 99:492-501.
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Am J Gastroenterol
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Soriano, A.1
Castells, A.2
Ayuso, C.3
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9
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Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA vs. percutaneous FNA
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Micames C, Jowell PS, White R, et al.: Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA vs. percutaneous FNA. Gastrointest Endosc 2003, 58:690-695.
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Gastrointest Endosc
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Micames, C.1
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White, R.3
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10
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0042835658
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Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreas
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Ammori JB, Colletti LM, Zalupski MM, et al.: Surgical resection following radiation therapy with concurrent gemcitabine in patients with previously unresectable adenocarcinoma of the pancreas. J Gastrointest Surg 2003, 7:766-772.
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J Gastrointest Surg
, vol.7
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Ammori, J.B.1
Colletti, L.M.2
Zalupski, M.M.3
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11
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Neoadjuvant preoperative chemoradiation in patients with pancreatic cancer
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Magnin V, Moutardier V, Giovannini MH, et al.: Neoadjuvant preoperative chemoradiation in patients with pancreatic cancer. Int J Radiat Oncol Biol Phys 2003, 55:1300-1304.
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Magnin, V.1
Moutardier, V.2
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Surgical treatment of pancreatic adenocarcinoma; actual survival and prognostic factors in 343 patients
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Kuhlmann KF, de Castro SM, Wesseling JG, et al.: Surgical treatment of pancreatic adenocarcinoma; actual survival and prognostic factors in 343 patients. Eur J Cancer 2004, 40:549-558.
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Kuhlmann, K.F.1
De Castro, S.M.2
Wesseling, J.G.3
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An evidence-based approach to the surgical management of resectable pancreatic adenocarcinoma
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Stojadinovic A, Brooks A, Hoos A, et al.: An evidence-based approach to the surgical management of resectable pancreatic adenocarcinoma. J Am Coll Surg 2003, 196:954-964.
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J Am Coll Surg
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Stojadinovic, A.1
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Hoos, A.3
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Concomitant laparoscopic gastric and biliary bypass and bilateral thoracoscopic splanchnotomy: The full package of minimally invasive palliation for pancreatic cancer
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Ali S, Ammori BJ: Concomitant laparoscopic gastric and biliary bypass and bilateral thoracoscopic splanchnotomy: the full package of minimally invasive palliation for pancreatic cancer. Surg Endosc 2003, 17:2028-2031.
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Surg Endosc
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Ali, S.1
Ammori, B.J.2
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Matched study of three methods for palliation of malignant pyloroduodenal obstruction
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Mittal A, Windsor J, Woodfield J, et al.: Matched study of three methods for palliation of malignant pyloroduodenal obstruction. Br J Surg 2004, 91:205-209.
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Br J Surg
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Mittal, A.1
Windsor, J.2
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A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
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Neoptolemos JP, Stocken DD, Friess H, et al.: A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 2004, 350:1200-1210. This randomized prospective trial represents one of the largest trials ever investigating adjuvant 5-fluorouracil and radiotherapy for pancreatic cancer. The authors conclude that chemotherapy is useful but chemoradiation may be harmful in patients treated after resection.
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N Engl J Med
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Neoptolemos, J.P.1
Stocken, D.D.2
Friess, H.3
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Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer
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Hu YC, Komorowski RA, Graewin S, et al.: Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer. Clin Cancer Res 2003, 9:4165-4171.
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Hu, Y.C.1
Komorowski, R.A.2
Graewin, S.3
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18
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Interferon-based adjuvant chemoradiation therapy after pancreaticoduodenectomy for pancreatic adenocarcinoma
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Picozzi VJ, Kozarek RA, Traverso LW: Interferon-based adjuvant chemoradiation therapy after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am J Surg 2003, 185:476-480. These investigators describe an interferon-based adjuvant therapy with actuarial survival at 1-year, 2-year, and 5-year periods of 95%, 64%, and 55%, respectively. This trial is now the focus of a larger study by the American College of Surgeons Oncology Group.
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Am J Surg
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Picozzi, V.J.1
Kozarek, R.A.2
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19
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Prognostic value of CA19-9 levels in patients with inoperable adenocarcinoma of the pancreas treated with gemcitabine
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Ziske C, Schlie C, Gorschluter M, et al.: Prognostic value of CA19-9 levels in patients with inoperable adenocarcinoma of the pancreas treated with gemcitabine. Br J Cancer 2003, 89:1413-1417.
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Br J Cancer
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Ziske, C.1
Schlie, C.2
Gorschluter, M.3
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Intraductal papillary mucinous neoplasms of the pancreas: An analysis of clinicopathologic features and outcome
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D'Angelica M, Brennan MF, Suriawinata AA: Intraductal papillary mucinous neoplasms of the pancreas: an analysis of clinicopathologic features and outcome. Ann Surg 2004, 239:400-408.
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Ann Surg
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D'Angelica, M.1
Brennan, M.F.2
Suriawinata, A.A.3
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21
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Preoperative predictors of malignancy in pancreatic intraductal papillary mucinous neoplasms
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Wiesenauer CA, Schmidt CM, Cummings OW, et al.: Preoperative predictors of malignancy in pancreatic intraductal papillary mucinous neoplasms. Arch Surg 2003, 138:610-617.
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Arch Surg
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Aggressive surgery for metastatic liver neuroendocrine tumors
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Norton JA, Warren RS, Kelly MG, et al.: Aggressive surgery for metastatic liver neuroendocrine tumors. Surgery 2003, 134:1057-1063.
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Surgery
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Norton, J.A.1
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Autoimmune pancreatitis: Pathological, clinical, and immunological features
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Kloppel G, Luttges J, Lohr M, et al.: Autoimmune pancreatitis: pathological, clinical, and immunological features. Pancreas 2003, 27:14-19.
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Pancreas
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Incidental pancreatic cysts: Clinicopathologic characteristics and comparison with symptomatic patients
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Fernandez-del Castillo C, Targarona J, Thayer SP, et al.: Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. Arch Surg 2003, 138:427-433. This group, known for their expertise in cystic lesions of the pancreas, reports that in patients with asymptomatic lesions less than 2 cm, the rate of premalignant cysts was as high as 46%. This calls into question the role of watchful waiting in the management of these lesions.
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Arch Surg
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Fernandez-Del Castillo, C.1
Targarona, J.2
Thayer, S.P.3
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Cystic lesions of the pancreas: Selection criteria for operative and nonoperative management in 209 patients
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Allen PJ, Jaques DP, D'Angelica M, et al.: Cystic lesions of the pancreas: selection criteria for operative and nonoperative management in 209 patients. J Gastrointest Surg 2003, 7:970-977.
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J Gastrointest Surg
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Allen, P.J.1
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D'Angelica, M.3
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