Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome

Best Practice and Research: Clinical Gastroenterology

Volumn 18, Issue 4, 2004, Pages 747-771

  Delvaux, Michel ^a  

^a CHU NANCY BRABOIS   (France)

Author keywords

Barostat; Brain imaging; Digestive motility; Distension tests; Enteric nervous system; Irritable bowel syndrome; Manometry; Motor profiles; Visceral hypersensitivity

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ALOSETRON; ALVERINE CITRATE; ASIMADOLINE; CALCITONIN GENE RELATED PEPTIDE; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR ANTAGONIST; CILANSETRON; CLONIDINE; FEDOTOZINE; KAPPA OPIATE RECEPTOR AGONIST; LOXIGLUMIDE; MEBEVERINE; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROTRANSMITTER; OCTREOTIDE; OTILONIUM BROMIDE; PINAVERIUM BROMIDE; SAREDUTANT; SEROTONIN 3 ANTAGONIST; SEROTONIN 4 AGONIST; SEROTONIN 4 ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; SOMATOSTATIN DERIVATIVE; SPASMOLYTIC AGENT; TEGASEROD; TRICYCLIC ANTIDEPRESSANT AGENT; TRIMEBUTINE; UNINDEXED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

ABDOMINAL PAIN; ANORECTAL PRESSURE; AUTONOMIC NERVOUS SYSTEM; BAROSTAT; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; COLON DISEASE; COLON MOTILITY; DRUG MECHANISM; DRUG TARGETING; EFFERENT NERVE; GALLSTONE; GASTROINTESTINAL DISEASE; HUMAN; HYPERSENSITIVITY REACTION; INTESTINE DISTENSION; INTESTINE FUNCTION DISORDER; INTESTINE INNERVATION; INTESTINE MOTILITY; INTESTINE TRANSIT TIME; IRRITABLE COLON; LOW DRUG DOSE; MOOD DISORDER; MYENTERIC PLEXUS; NONHUMAN; PARASYMPATHETIC INNERVATION; PATHOPHYSIOLOGY; PELVIC NERVE; PERCEPTIVE THRESHOLD; PHASE 3 CLINICAL TRIAL; PUDENDAL NERVE; REVIEW; SENSORIMOTOR FUNCTION; SENSORIMOTOR NEUROPATHY; SENSORY NERVE; SPINAL NERVE; STRESS; SYMPATHETIC INNERVATION; UPPER GASTROINTESTINAL TRACT; VAGUS NERVE;

ANIMALS; CENTRAL NERVOUS SYSTEM; ENTERIC NERVOUS SYSTEM; GASTROINTESTINAL AGENTS; GASTROINTESTINAL MOTILITY; HUMANS; IRRITABLE BOWEL SYNDROME; MANOMETRY;

EID: 4344609725     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpg.2004.06.004     Document Type: Review

References (152)

1. D.A. Drossman W.E. Whitehead M. Camilleri Irritable bowel syndrome: A technical review for practice guideline development Gastroenterology 112 1997 2120-2137
2. J.E. Kellow L.J. Miller S.F. Phillips A.R. Zinsmeister Altered small bowel motility in irritable bowel syndrome is correlated with symptoms Gastroenterology 92 1987 1885-1893
3. L. Bueno J. Fioramonti Y. Ruckebusch et al. Evaluation of colonic myoelectrical activity in health and functional disorders Gut 21 1980 480-485
4. J.E. Kellow M. Delvaux F. Azpiroz et al. Principles of applied neurogastroenterology: Physiology/Motility-sensation Gut 45 1999 II17-II24
5. J. Ritchie Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome Gut 14 1973 125-132
6. R.B. Lasser J.H. Bond M.D. Levitt The role of intestinal gas in functional abdominal pain N. Engl. J. Med. 293 1975 524-526
7. E.A. Mayer H.E. Raybould Role of visceral afferent mechanisms in functional bowel disorders Gastroenterology 99 1990 1688-1704
8. N. Mei Intestinal chemosensitivity Physiol. Rev. 65 1985 211-237
9. F. Cervero Sensory innervation of the viscera: Peripheral basis of visceral pain Pharmacol. Rev. 74 1994 95-138
10. J.M. Besson La douleur: Aspects physiopharmacologiques C.R. Soc. Biol. 186 1992 26-36
11. N. Mei Vagal glucoreceptors in the small intestine of the cat J. Physiol. (Lond.) 282 1978 485-506
12. D.H. Silverman J.A. Munakata H. et al. Ennes Regional cerebral activity in normal and pathological perception of visceral pain Gastroenterology 112 1997 64-72
13. J.S. Davison Innervation of the gastro-intestinal tract, In: J. Christensen D.L. Wingate (Eds.). A Guide to Gastrointestinal Motility 1983 Wright-PSG Bristol 1-47
14. L. Bueno J. Fioramonti M. Delvaux J. Frexinos Mediators and pharmacology of visceral sensitivity: From basic to clinical investigations Gastroenterology 112 1997 1714-1743
15. J. Christensen The enteric nervous system, In: D.L. Wingate D. Kumar (Eds.). An Illustrated Guide to Gastrointestinal Motility 1993 Churchill Livingstone London 10-31
16. J.M.A. Laird B. Chang R. Hoey F. Cervero Capsaicin-sensitive vagal afferent fibers and gastric motility: Evidence for an axon reflex mechanism J. Gastrointest. Mot. 3 1991 138-143
17. J.M. Rouillon F. Azpiroz J. Malagelada Reflex changes in intestinal tone: Relationship to perception Am. J. Physiol. 261 1991 G280-G286
18. F. Azpiroz J.R. Malagelada Perception and reflex relaxation of the stomach in response to gut distension Gastroenterology 98 1990 1193-1198
19. J. Frexinos L. Bueno J. Fioramonti Diurnal changes in myoelectric spiking activity of human colon Gastroenterology 88 1985 1104-1110
20. E.S. Bjornsson W.D. Chey U. et al. Ladabaum Differential 5-HT3 mediation of human gastrocolonic response and colonic peristaltic reflex Am. J. Physiol. 275 1998 G498-G505
21. D. Louvel M. Delvaux G. et al. Staumont Intracolonic injection of glycerol: A model for abdominal pain in irritable bowel syndrome? Gastroenterology 110 1996 351-361
22. H.C. Tjeerdsma mout L.M.A. Akkermans Voluntary suppression of defecation delays gastric emptying Dig. Dis. Sci. 38 1983 832-836
23. K. Otake D.J. Reis D.A. Ruggiero Afferents to the midline thalamus issue collaterals to the nucleus tractus solitarii: An anatomical basis for thalamic and visceral reflex integration J. Neurosci. 14 1994 5694-5707
24. P.L.R. Andrews Modulation of visceral afferent activity as a therapeutic possibility for gastro-intestinal disorders, In: N.W. Read (Ed.). Irritable Bowel Syndrome 1991 Blackwell London 91-121
25. M. Delvaux Etude des récepteurs du muscle lisse digestif: Intérêt des cellules musculaires isolées Gastroenterol. Clin. Biol. 18 1994 475-485
26. M.D. Levitt Production and excretion of hydrogen gas in man N. Engl. J. Med. 281 1969 122-127
27. J.H. Bond M.D. Lewitt Investigation of the small bowel transit time in man utilizing pulmonary hydrogen (H 2 ) measurements J. Lab. Clin. Med. 85 1975 546-555
28. P.A. Cann N.W. Read C. Brown et al. Irritable bowel syndrome: Relationship of disorders in the transit of a single solid meal to symptom patterns Gut 24 1983 405-411
29. S. Chaussade A. Khyari H. Roche et al. Determination of total and segmental colonic transit time in constipated patients. Results in 91 patients with a new simplified method Dig. Dis. Sci. 34 1989 1168-1172
30. A.M. Metcalf S.F. Phillips A.R. Zinsmeister et al. Simplified assessment of segmental colonic transit time Gastroenterology 92 1987 40-47
31. L. Picon M. Lemann B. Flourié et al. Right and left colonic transit after eating assessed by a dual isotopic technique in healthy humans Gastroenterology 103 1992 80-85
32. M. Proano M. Camillieri S.F. Phillips et al. Transit of solids through the human colon: Regional quantification in the unprepared bowel Am. J. Physiol. 258 1990 G856-G862
33. M. Thumshirn B. Coulie M. Camilleri et al. Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome Aliment. Pharmacol. Ther. 14 2000 869-878
34. M. Camilleri Perfused tube manometry, In: D.L. Wingate D. Kumar (Eds.). An Illustrated Guide to Gastrointestinal Motility 1993 Churchill Livingstone London 183-199
35. J.E. Kellow T.J. Borody S.F. Phillips et al. Human interdigestive motility: Variations in patterns from oesophagus to colon Gastroenterology 91 1986 386-395
36. F. Narducci G. Bassoti M. Gaburri A. Morelli Twenty four hours manometric recording of colonic motor activity in healthy man Gut 28 1987 17-25
37. G. Bassotti M. Gaburri Manometric investigation of high amplitude propagated contractile activity of the human colon Am. J. Physiol. 255 1988 G660-G664
38. M. von der Ohe R.B. Hanson M. Camilleri Barostat recordings of intracolonic pressure activity: Comparison with manometry in healthy subjects (abstract) Gastroenterology 103 1992-1378
39. W.E. Whitehead M. Delvaux Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract Dig. Dis. Sci. 42 1997 223-241
40. T. Lembo J. Munakata H. Mertz Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome Gastroenterology 107 1994 1686-1696
41. C. Blanc M. Delvaux C. Maillot et al. Distension protocols for evaluation of rectal sensitivity: The simplest, the best? (abstract) Gastroenterology 114 1998 A722
42. K.R. Jones W.E. Whitehead K. Meyer Agreement between different methods of measuring pain sensitivity (abstract) Gastroenterology 116 1999 A1012
43. M. Delvaux Y. Aggadi C. Blanc J. Frexinos Protocols of distension to evaluate visceral sensitivity in patients with irritable bowel syndrome (IBS): Is the simplest, the best? (abstract) Gastroenterology 120 2001 A133
44. B.D. Naliboff J. Munakata S. Fullerton et al. Evidence of two distinct perceptual alterations in irritable bowel syndrome Gut 41 1997 505-512
45. M.J. Ford M. Camilleri A.R. Zinsmeister R.B. Hanson Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon Gastroenterology 109 1995 1772-1780
46. M. Bradette M. Delvaux G. Staumont et al. Evaluation of colonic sensory thresholds in IBS patients using a barostat: Definition of optimal conditions and comparison with healthy subjects Dig. Dis. Sci. 39 1994 449-457
47. M.J. Vassallo M. Camilleri S.F. Phillips et al. Colonic tone and motility in patients with irritable bowel syndrome Mayo Clin. Proc. 67 1992 725-731
48. E. Lagier M. Delvaux B. Vellas et al. Influence of age on rectal tone and sensitivity to distension in healthy subjects Neurogastroenterol. Mot. 11 1999 101-108
49. V. Loening-Baucke S. Anuras Effect of age and sex on ano-rectal manometry Am. J. Gastroenterol. 80 1985 50-53
50. W.M. Sun N.W. Read Anorectal function in normal human subjects: Effect of gender Int. J. Colorectal Dis. 4 1989 188-196
51. C. Blanc C. Maillot M. Delvaux et al. Influence of gender and menstrual cycle on visceral perception in healthy volunteers (abstract) Gastroenterology 116 1999 A724
52. E. Lagier M. Delvaux S. Metivier et al. Colonic tone influences thresholds of sensory perception to luminal distension in IBS patients (abstract) Gastroenterology 110 1996 A700
53. A.M. Bell J.H. Pemberton R.B. Hanson A.R. Zinsmeister Variations in muscle tone of the human rectum: Recordings with an electromechanical barostat Am. J. Physiol. 260 1991 G17-G25
54. C.J. Steadman S.F. Phillips M. Camilleri et al. Variation of muscle tone in the human colon Gastroenterology 101 1991 373-381
55. Q. Aziz J. Andresson S. Valind et al. Identification of human brain loci processing oesophageal sensation using positron emission tomography Gastroenterology 113 1997 50-60
56. Q. Aziz J.C. Rothwell S. Hamdy et al. The topographic representation of esophageal motor function on the human cerebral cortex Gastroenterology. 111 1996 855-862
57. E.M. Quigley P.H. Deprez P. Hellstrom et al. mbulatory intestinal manometry: A consensus report on its clinical role Dig. Dis. Sci. 92 1997 2395-2400
58. P. Fleckenstein A. Ooigaard Electrical spike activity in the human small intestine. A multiple electrode study of fasting diurnal variations Dig. Dis. Sci. 23 1978 776-780
59. I. DeWever C. Eeckhout G. Van Trappen J. Hellemans Disruptive effect of test meals on interdigestive motor complex in dogs Am. J. Physiol. 235 1978 E661-E665
60. G. Staumont M. Delvaux J. Fioramonti et al. Differences between jejunal myoelectric activity after a meal and during phase II of migrating motor complexes in healthy humans Dig. Dis. Sci. 37 1992 1554-1561
61. T. Borody D. Byrnes D. Bell L. Henderson The migrating motor complex - Its relation to circulating CCK, motilin and pancreatic polypeptide in irritable bowel syndrome patients and in controls (abstract) Clin. Res. 32 1984 23A
62. D.A. Gorard G.W. Libby M.J. Farthing Ambulatory small motility in diarrhoea-predominant irritable bowel syndrome Gut 35 1994 203-210
63. J.E. Kellow S.F. Phillips Altered small bowel motility in irritable bowel syndrome is correlated with symptoms Gastroenterology 92 1987 1885-1893
64. J.E. Kellow R.C. Gill D.L. Wingate Prolonged ambulant recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome Gastroenterology 98 1990 1208-1218
65. J.G.C. Kingham R. Brown R. Colson M.L. Clarck Jejunal motility in patients with functional abdominal pain Gut 25 1984 375-380
66. T. Schmidt N. Hackelsberger R. Widmer et al. Ambulatory 24-hour jejunal motility in diarrhea-predominant irritable bowel syndrome Scand. J. Gastroenterol. 31 1997 581-589
67. P.K. Small M.A. Loudon C.M. Hau et al. Large scale ambulatory study of post-prandial jejunal motility in irritable bowel syndrome Scand. J. Gastroenterol. 32 1997 39-47
68. J.E. Kellow G.M. Eckersley M.P. Jones Enteric and central contributions to intestinal dismotility in irritable bowel syndrome Dig. Dis. Sci. 37 1992 168-174
69. J.E. Kellow L.J. Miller S.F. Phillips A.R. Zinsmeister Dysmotility of the small intestine in irritable bowel syndrome Gut 29 1988 1236-1243
70. R. Jian Y. Najean J.J. Bernier Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhea by a dual isotope technique Gut 25 1984 728-731
71. I.F. Totman C.C. Price Bloated irritable bowel syndrome defined by dynamic 99m Tc bran scan Lancet ii 1986 364-366
72. P.A. Cann N.W. Read C. Brown Irritable bowel syndrome: Relationship of disorders in the transit of a single solid meal to symptom patterns Gut 24 1983 405-411
73. A. Aggarwal T.F. Cutts T.L. Abell et al. Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities Gastroenterology 106 1994 945-950
74. L. Bueno J. Fioramonti J. Frexinos Y. Ruckebusch Colonic myoelectrical activity in diarrhoea and constipation Hepatogastroenterology 27 1980 381-389
75. S.N. Reddy G. Bazzocchi S. Chan et al. Effect of eating on colonic motility and transit in patients with functional diarrhea. Simultaneous scintigraphic and manometric evaluations Gastroenterology 101 1991 1298-1306
76. G. Bazzocchi J. Ellis J. Villanueva-Meyer et al. Post-prandial colonic transit and motor activity in chronic constipation Gastroenterology 98 1990 686-693
77. M.A. Sullivan S. Cohen W.J.J. Snape Colonic myoelectrical activity in irritable bowel syndrome. Effect of eating and anticholinergics N. Engl. J. Med. 298 1978 878-883
78. C. Niederau S. Faber M. Karaus Cholecystokinin's role in regulation of colonic motility in health and irritable bowel syndrome Gastroenterology 102 1992 1889-1898
79. F. Narducci G. Bassotti M.T. Granata et al. Colonic motility and gastric emptying in patients with irritable bowel syndrome. Effect of pretreatment with octilinium bromide Dig. Dis. Sci. 31 1986 241-246
80. W.E. Whitehead M.D. Crowell J.C. Robinson Effect of stressful life events on bowel symptoms: Subjects with irritable bowel symptoms compared with subjects without bowel dysfunction Gut 33 1992 825-830
81. F. Narducci nape W.M. Battle Increased colonic motility during exposure to a stressful situation Dig. Dis. Sci. 30 1985 40-44
82. P. Welgan H. Meshkinpour M. Beeler Effect of anger on colon motor and myoelectrical activity in irritable bowel syndrome Gastroenterology 94 1988 1150-1156
83. S. Fukudo J. Suzuki Colonic motility, autonomic function and gastrointestinal hormones under psychological stress in irritable bowel syndrome Tokyo J. Exp. Med. 151 1987 373-385
84. F. Azpiroz J.R. Malagelada Physiological variations in canine gastric tone measured by an electronic barostat Am. J. Physiol. 248 1985 G229-G237
85. W.E. Whitehead B. Holtkotter P. Enck et al. Tolerance for recto-sigmoid distension in irritable bowel syndrome Gastroenterology 98 1990 1187-1192
86. A.M. Accarino F. Azpiroz J.R. Malagelada Symptomatic responses to stimulation of sensory pathways in the jejunum Am. J. Physiol. 263 1992 G673-G677
87. K.C. Trimble R. Farouk A. Pryde et al. Heightened visceral sensation in functional gastro-intestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity Dig. Dis. Sci. 40 1995 1607-1613
88. C.Y. Francis L.A. Houghton P.J. Whorwell et al. Enhanced sensitivity of the whole gut in patients with irritable bowel syndrome (IBS) (abstract) Gastroenterology 108 1995 A601
89. H. Mertz B. Naliboff J. Munakata et al. Altered rectal perception is a biological marker of patients with irritable bowel syndrome Gastroenterology 109 1995 40-52
90. M. Delvaux D. Louvel E. Lagier et al. The kappa agonist Fedotozine relieves hypersensitivity to colonic distension in patients with irritable bowel syndrome (IBS) Gastroenterology 116 1999 38-45
91. A. Prior N.W. Read Reduction of rectal sensitivity and postprandial motility by granisetron, a 5-HT3 receptor antagonist, in patients with irritable bowel syndrome Aliment. Pharmacol. Ther. 7 1993 175-180
92. F. Harraf M. Schmulson L. Saba et al. Subtypes of constipation predominant irritable bowel syndrome based on rectal perception Gut 43 1998 388-394
93. G.J. Oettle K.W. Heaton Rectal dissatisfaction in the irritable bowel syndrome Int. J. Colorectal Dis. 1 1986 183-185
94. A.M. Accarino F. Azpiroz J.R. Malagelada Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome Gastroenterology 108 1995 636-643
95. S.M. Collins B. Vallance G. Barbara M. Borgaonkar Putative inflammatory and immunological mechanisms in functional bowel disorders Baillieres Best Pract. Res. Clin. Gastroenterol. 13 1999 429-436
96. N.A. Chaudhary S.C. Truelove The irritable bowel syndrome Q. J. Med. 31 1962 307-322
97. A.J. Bergin T.C. Donnelly M.W. McKendrick N.W. Read Changes in ano-rectal function in persistent bowel disturbance following salmonella gastroenteritis Eur. J. Gastroenterol. Hepatol. 5 1993 617-620
98. K.A. Gwee J.C. Graham M.W. McKendrick et al. Psychometric scores and persistence of irritable bowel after infectious diarrhoea Lancet 347 1996 150-153
99. K.R. Neal J. Hebden R. Spiller Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: Postal survey of patients Br. Med. J. 314 1997 779-782
100. M.J. Farthing J.E. Lennard-Jones Sensibility of the rectum to distension and the anorectal distension reflex in ulcerative colitis Gut 19 1978 64-69
101. S.S. Rao N.W. Read J.A. Stobart et al. Anorectal contractility under basal conditions and during rectal infusion of saline in ulcerative colitis Gut 29 1988 769-777
102. S.S. Rao N.W. Read C. Brown et al. Studies on the mechanism of bowel disturbance in ulcerative colitis Gastroenterology 93 1987 934-940
103. V. Loening-Baucke A.M. Metcalf S. Shirazi Rectosigmoid motility in patients with quiescent and active ulcerative colitis Am. J. Gastroenterol. 84 1989 34-39
104. M. Bouin M. Delvaux C. Blanc et al. Intrarectal injection of glycerol induces hypersensitivity to rectal distension in healthy subjects without modifying rectal compliance Eur. J. Gastroenterol. Hepatol. 13 2001 573-580
105. W. Hasler H. Soudah C. Owyang A somatostatine analogue inhibits afferent pathways mediating perception of rectal distension Gastroenterology 104 1993 1390-1397
106. V. Plourde T. Lembo Z. Shui et al. Effects of the somatostatin analogue octreotide on rectal afferent nerves in humans Am. J. Physiol. 265 1993 G742-G751
107. M. Bradette G. Staumont M. Delvaux et al. Somatostatin analogue increases thresholds of discomfort and pain perception to colonic distension in irritable bowel syndrome patients Dig. Dis. Sci. 39 1994 1171-1178
108. W.D. Chey A. Beydoun D.J. Roberts et al. Octreotide reduces perception of rectal electrical stimulation by spinal afferent pathway inhibition Am. J. Physiol. 269 1995 G821-G826
109. H. Mertz V. Morgan G. Tanner et al. Regional cerebral activation in irritable bowel syndrome and control subjects with painful and non-painful rectal distension Gastroenterology 118 2000 842-848
110. B. Naliboff S. Derbyshire J. Munakata et al. Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulation Psychosom. Med. 63 2001 365-375
111. A. Ploghaus I. Tracey J.S. Gati et al. Dissociating pain from its anticipation in the human brain Science 284 1999 1979-1981
112. J. Erckenbrecht Noise and intestinal motor alterations, In: L. Buéno S. Collins J.L. Junien (Eds.). Stress and Digestive Motility 1989 John Libbey Eurotext London 93-96
113. H. Mönnikes I. Heymann-Mönnikes R. Arnold Patients with irritable bowel syndrome have alterations in the CNS-modulation of visceral afferent perception (abstract) Gut 37 1995 A168
114. S. Métivier M. Delvaux D. Louvel et al. Influence of stress on sensory thresholds to rectal distension in healthy volunteers (abstract) Gastroenterology 110 1996 A717
115. T. Lembo S. Fullerton D. Diehl et al. Symptom duration in patients with irritable bowel syndrome Am. J. Gastroenterol. 91 1996 898-905
116. S. Berman J. Munakata B.D. Naliboff et al. Gender differences in regional brain responses to visceral pressure in IBS patients Eur. J. Pain 4 2000 157-172
117. A.M. Accarino F. Azpiroz J.R. Malagelada Attention and distraction: Effect on gut perception Gastroenterology 113 1997 415-422
118. J.E. Kellow G.M. Eckeerskey M.P. Jones Enhanced perception of physiological intestinal motility in the irritable bowel syndrome Gastroenterology 101 1991 1621-1627
119. M. Delvaux Stress and visceral perception Can. J. Gastroenterol. 13 1999 32A-36A
120. A. Prior D. Maxton P.J. Whorwell Anorectal manometry in irritable bowel syndrome: Differences between diarrhoea and constipation-predominant subjects Gut 31 1990 458-462
121. W.E. Whitehead B.T. Engel M.M. Schuster Irritable bowel syndrome. Physiological and psychological differences between diarrhea-predominant and constipation-predominant patients Dig. Dis. Sci. 25 1980 404-413
122. A. Prior E. Sorial W.M. Sun N.W. Read Irritable bowel syndrome: Difference between patients who show rectal sensitivity and those who do not Eur. J. Gastroenterol. Hepatol. 5 1993 343-349
123. W.J. Snape G.M. Carlson S. Cohen Colonic myoelectric activity in the irritable bowel syndrome Gastroenterolgoy 70 1976 326-330
124. C.H. Clemens M. Samsom G.P. Van Berge Henegouwen A.J. Smout Abnormalities of left colonic motility in ambulant nonconstipated patients with irritable bowel syndrome Dig. Dis. Sci. 48 2003 74-82
125. C.H. Clemens M. Samsom J.M. Roelofs et al. Association between pain episodes and high amplitude propagated pressure waves in patients with irritable bowel syndrome Am. J Gastroenterol. 98 2003 1838-1843
126. P.R. Evans E.J. Bennet Y.-T. Bak et al. Jejunal sensorimotor dysfunction in irritable bowel syndrome - Clinical and psychosocial features Gastroenterology 110 1996 393-404
127. J. Serra F. Azpiroz J.-R. Malagelada Intestinal gas dynamics and tolerance in humans Gastroenterology 115 1998 542-550
128. M.P. Caldarella J. Serra F. Azpiroz J.R. Malagelada Prokinetic effects in patients with intestinal gas retention Gastroenterology 122 2002 1748-1755
129. E.A. Mayer G.F. Gebhart Basic and clinical aspects of visceral hyperalgesia Gastroenterology 107 1994 271-293
130. M. Bouin V. Plourde M. Boivin et al. Rectal distention testing in patients with irritable bowel syndrome: Sensitivity, specificity, and predictive values of pain sensory thresholds Gastroenterology 122 2002 1771-1777
131. M. Camilleri Study of human gastroduodenojejunal motility. Applied physiology in clinical practice Dig. Dis. Sci. 38 1993 785-794
132. P. Enck Biofeedback training in disordered defecation: A critical review Dig. Dis. Sci. 38 1993 1953-1960
133. W.E. Whitehead W.G. Thompson Motility as a therapeutic modality, In: M.M. Schuster (Ed.). Atlas of Gastrointestinal Motility in Health and Disease 1993 Williams & Wilkins Baltimore 300-316
134. W.M. Gonsalkorale V. Miller A. Afzal P.J. Whorwell Long term benefits of hypnotherapy for irritable bowel syndrome Gut 52 2003 1623-1629
135. R. Lea L.A. Houghton E.L. Calvert et al. Gut-focused hypnotherapy normalizes disordered rectal sensitivity in patients with irritable bowel syndrome Aliment. Pharmacol. Ther. 17 2003 635-642
136. K.B. Klein Controlled treatment trials in the irritable bowel syndrome: A critique Gastroenterology 95 1988 232-241
137. G. Farrugia M. Camilleri W.E. Whitehead Therapeutic strategies for motility disorders Gastroenterol. Clin. North Am. 25 1996 225-246
138. T. Poynard S. Naveau B. Mory J.C. Chaput Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome Aliment. Pharmacol. Ther. 8 1994 499-510
139. T. Poynard C. Regimbeau Y. Benhamou Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome Aliment. Pharmacol. Ther. 15 2001 355-361
140. J. Jailwala T.F. Imperiale K. Kroenke Pharmacologic treatment of the irritable bowel syndrome: A systematic review of randomized, controlled trials Ann. Intern. Med. 133 2 2000 136-147
141. L.A. Houghton J.M. Foster P.J. Whorwell Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers Aliment. Pharmacol. Ther. 14 2000 775-782
142. M. Camilleri A.R. Northcutt S. Kong et al. Efficacy and safety of alosetron in women with irritable bowel syndrome: A randomised, placebo-controlled trial Lancet 355 2000 1035-1040
143. C.M. Prather M. Camilleri A.R. Zinsmeister et al. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome Gastroenterology 118 2000 463-468
144. S.A. Müller-Lissner I. Fumagalli K.D. Bardhan et al. Tegaserod, a 5HT 4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation Aliment. Pharmacol. Ther. 15 2001 1655-1666
145. M. Delvaux D. Louvel J.P. Mamet et al. Effect of Alosetron on responses to colonic distension in patients with irritable bowel syndrome Aliment. Pharmacol. Ther. 12 1998 849-855
146. I. Schwetz B. Naliboff J. Munakata et al. Anti-hyperalgesic effect of octreotide in patients with irritable bowel syndrome Aliment. Pharmacol. Ther. 19 2004 123-131
147. P. Ducrotté M. Njeunga I. Berkelmans P. Denis Symptomatic effect of octreotide in long term treatment of patients with severe epigastric pain (abstract) Gastroenterol. Clin. Biol. 26 2002 A156
148. S. Delgado-Aros H.J. Chial M. Camilleri et al. Effects of a kappa opioid agonist, asimadolime, on satiation and gastrointestinal motor and sensory functions in humans Am. J. Physiol. 284 2003 G558-G566
149. M. Delvaux A. Beck J. Jacob et al. Asimadoline, a kappa opioid agonist, decreases pain induced by colonic distension in patients with irritable bowel syndrome Aliment. Pharmacol. Ther. 20 2004 237-246
150. M. Dapoigny J.L. Abitbol B. Fraitag Efficacy of peripheral kappa agonist fedotozine versus placebo in treatment of irritable bowel syndrome. A multicenter dose - Response study Dig. Dis. Sci. 40 1995 2244-2248
151. Y. Tache V. Martinez M. Million L. Wang Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: Role of brain corticotropin-releasing factor receptors Am. J. Physiol. 280 2001 G173-G177
152. H. Monnikes J.J. Tebbe M. Hildebrandt et al. Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity Dig. Dis. 19 2001 201-211