Gynaecomastia in HIV-infected men on highly active antiretroviral therapy: Association with efavirenz and didanosine treatment

Antiviral Therapy

Volumn 9, Issue 4, 2004, Pages 511-517

  Mira, José A ^a   Lozano, Fernando ^a   Santos, Jesús ^b   Ramayo, Emilia ^a   Terrón, Alberto ^c   Palacios, Rosario ^b   León, Eva M ^a   Márquez, Manuel ^b   Macías, Juan ^a   Fernández Palacin, Ana ^a   Gómez Mateos, Jesús ^a   Pineda, Juan A ^a  

^a HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^c Hospital Universitario de Jerez   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ANDROSTANOLONE; DIDANOSINE; EFAVIRENZ; INDINAVIR; LAMIVUDINE; NELFINAVIR; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; SEX HORMONE; STAVUDINE; TESTOSTERONE; ZIDOVUDINE;

ADULT; AGED; ANTIVIRAL ACTIVITY; ARTICLE; BIOAVAILABILITY; BLOOD SAMPLING; CONTROLLED STUDY; FEMALE; GYNECOMASTIA; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HORMONAL REGULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOGONADISM; INFECTION CONTROL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SIDE EFFECT; TESTOSTERONE BLOOD LEVEL;

ADULT; AGED; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COHORT STUDIES; DIDANOSINE; GYNECOMASTIA; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; OXAZINES; REVERSE TRANSCRIPTASE INHIBITORS; TESTOSTERONE; TRIGLYCERIDES;

EID: 4344599725     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Pantanowitz L & Connolly JL. Pathology of the breast associated with HIV/AIDS. Breast Journal 2002; 8:234-243.
2. Ismail AA & Barth JH. Endocrinology of gynaecomastia. Annals of Clinical Biochemistry 2001; 38:596-607.
3. Peyriere H, Mauboussin JM, Rouanet I, Merle C, Sotto A, Arnaud A, Hillaire-Buys D & Balmes P. Report of gynecomastia in five male patients during antiretroviral therapy for HIV infection. AIDS 1999; 13:2167-2169.
4. Melbourne KM, Brown SL & Silverblatt FJ. Gynecomastia with stavudine treatment in an HIV-positive patient. Annals of Pharmacotherapy 1998; 32:1108.
5. Schurmann D, Bergmann F, Ehrenstein T & Padberg J. Gynecomastia in a male patient during protease inhibitor treatment for acute HIV disease. AIDS 1998; 12:2232-2233.
6. Caeiro JP, Visnegarwala F & Rodríguez MC. Gynecomastia associated with indinavir therapy. Clinical Infectious Diseases 1998; 27:1539-1540.
7. Manfredi R, Calza L & Chiodo F. Gynecomastia associated with highly active antiretroviral therapy. Annals of Pharmacotherapy 2001; 35:438-439.
8. Arranz Caso JA, de Miguel Prieto J, Casas E & Sanz J. Gynecomastia without lipodystrophy syndrome in HIV-infected men treated with efavirenz. AIDS 2001; 15:1447-1448.
9. Qazi NA, Morlese JF, King DM, Ahmad RS, Gazzard BC & Nelson MR. Gynecomastia without lipodystrophy in HIV-1-seropositive patients on efavirenz: an alternative hypothesis. AIDS 2002; 16:506-507.
10. Paech J, Lorenzen T, von Krosigk A, Graefe K, Stoehr A & Plettenberg A. Gynaecomastia in HIV-infected men: association with effects of antiretroviral therapy. AIDS 2002; 16:1193-1194.
11. Toma E & Therrien R. Gynecomastia during indinavir antiretroviral therapy in HIV infection. AIDS 1998; 12:681-682.
12. Herry I, Bernard L, de Truchis P & Perronne C. Hypertrophy of the breast in a patient with indinavir. Clinical Infections Diseases 1997; 25:937-938.
13. Evans DL, Pantanowitz L, Dezube BJ & Aboulafia DM. Breast enlargement in 13 men who were seropositive for human immunodeficiency virus. Clinical Infectious Diseases 2002; 35:1113-1119.
14. Benveniste O, Simon A & Herson S. Successful percutaneous dihydrotestosterone treatment of gynecomastia occurring during highly active antiretroviral therapy: four cases and a review of the literature. Clinical Infectious Diseases 2001; 33:891-893.
15. García-Benayas T, Blanco F, Martín-Carbonero L, Valencia E, Barrios A, González-Lahoz J & Soriano V. Gynecomastia in HIV-infected patients receiving antiretroviral therapy. AIDS Research & Human Retroviruses 2003; 19:739-741.
16. Vermeulen A, Verdonack L & Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology & Metabolism 1999; 84:3666-3672.
17. Harmon J & Aliapoulios MA. Gynecomastia in marihuana users. New England Journal of Medicine 1972; 287:936.
18. Thompson DF & Carter JR. Drug-induced gynecomastia. Pharmacotherapy 1993; 13:37-45.
19. Cates W Jr & Pope JN. Gynecomastia and cannabis smoking. A nonassociation among US Army soldiers. American Journal of Surgery 1977; 134:613-615.
20. Mauss S. HIV-associated lipodystrophy syndrome. AIDS 2000; 14(Suppl. 3):197-207.
21. Grispoon S & Bilezikian JP. HIV disease and the endocrine system. New England Journal of Medicine 1992; 327:1360-1365.
22. Dobs AS, Dempsey MA, Ladenson PW & Polk BF. Endocrine disorders in men infected with human immunodeficiency virus. American Journal of Medicine 1988; 84:611-616.
23. Collazos J, Martinez G, Mayo J & Ibarra S. Sexual hormones in HIV-infected patients: the influence of antiretroviral therapy. AIDS 2002; 16:934-937.
24. Rietschel P, Corcoran C, Stanley T, Basgoz N, Klibanski A & Grinspoon SK. Prevalence of hypogonadism among men with weight loss related to human immunodeficiency virus infection who were receiving highly active antiretroviral therapy. Clinical Infectious Diseases 2000; 31:1240-1244.
25. Mylonakis E, Koutkia P & Grinspoon S. Diagnosis and treatment of androgen deficiency in human immunodeficiency virus-infected men and women. Clinical Infectious Diseases 2001; 33:857-864.
26. Vermeulen A & Kaufman JM. Diagnosis of hypoandrogenism in the aging male. Aging Male 2002; 5:170-176.
27. Morley JE & Perry III HM. Androgen treatment of male hypogonadism in older males. Journal of Steroid Biochemistry & Molecular Biology 2003; 85:367-373.