Antigen epitope of Helicobacter pylori vacuolating cytotoxin A

World Journal of Gastroenterology

Volumn 10, Issue 16, 2004, Pages 2340-2343

  Liu, Xiu Li ^a   Li, Shu Qin ^a   Liu, Chun Jie ^a   Tao, Hao Xia ^a   Zhang, Zhao Shan ^a  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTISERUM; BACTERIAL ANTIGEN; EPITOPE; ESCHERICHIA COLI ENTEROTOXIN; HELICOBACTER PYLORI VACCINE; IMMUNOGLOBULIN G; VACUOLATING TOXIN;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGENICITY; ARTICLE; BIOINFORMATICS; CELL VACUOLE; CONTROLLED STUDY; FEMALE; HELA CELL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; NONHUMAN; PLASMID; PREDICTION;

EID: 4344580565     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v10.i16.2340     Document Type: Article

References (26)

1. Telford JL, Ghiara P, Dell'Orco M, Comanducci M, Burroni D, Bugnoli M, Tecce MF, Censini S, Covacci A, Xiang Z. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med 1994; 179: 1653-1658
2. van Amsterdam K, van Vliet AH, Kusters JG, Feller M, Dankert J, van der Ende A. Induced Helicobacter pylori vacuolating cytotoxin VacA expression after initial colonisation of human gastric epithelial cells. FEMS Immunol Med Microbiol 2003; 39: 251-256
3. Inui T, Mizuno S, Takai K, Nakagawa M, Uchida M, Fujimiya M, Asakawa A, Inui A. Helicobacter pylori cytotoxin: a novel ligand for receptor-like protein tyrosine phosphatase beta. Int J Mol Med 2003; 12: 917-921
4. Cho SJ, Kang NS, Park SY, Kim BO, Rhee DK, Pyo S. Induction of apoptosis and expression of apoptosis related genes in human epithelial carcinoma cells by Helicobacter pylori VacA toxin. Toxicon 2003; 42: 601-611
5. Toro Rueda C, Garcia-Samaniego J, Casado Farinas I, Rubio Alonso M, Baquero Mochales M. Clinical importance of the CagA and VacA proteins and of the host factores in the development of peptic ulcer in patients infected by Helicobacter pylori. Rev Clin Esp 2003; 203: 430-433
6. Parsonnet J, Hansen S, Rodriguez L, Gelb AB, Warnke RA, Jellum E, Orentreich N, Vogelman JH, Friedman GD. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994; 330: 1267-1271
7. Yuan JP, Li T, Shi XD, Hu BY, Yang GZ, Tong SQ, Guo XK. Deletion of Helicobacter pylori vacuolating cytotoxin gene by introduction of directed mutagenesis. World J Gastroenterol 2003; 9: 2251-2257
8. Gebert B, Fischer W, Weiss E, Hoffmann R, Haas R. Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 2003; 301: 1099-1102
9. Qiao W, Hu JL, Xiao B, Wu KC, Peng DR, Atherton JC, Xue H. cagA and vacA genotype of Helicobacter pylori associated with gastric diseases in Xi'an area. World J Gastroenterol 2003; 9: 1762-1766
10. Caputo R, Tuccillo C, Manzo BA, Zarrilli R, Tortora G, Blanco Cdel V, Ricci V, Ciardiello F, Romano M. Helicobacter pylori VacA toxin up-regulates vascular endothelial growth factor expression in MKN 28 gastric cells through an epidermal growth factor receptor-, cyclooxygenase-2-dependent mechanism. Clin Cancer Res 2003; 9: 2015-2021
11. Wang J, van Doorn LJ, Robinson PA, Ji X, Wang D, Wang Y, Ge L, Telford JL, Crabtree JE. Regional variation among vacA alleles of Helicobacter pylori in China. J Clin Microbiol 2003; 41: 1942-1945
12. Cover TL, Blaser MJ. Purification and characterization of the vacuolating toxin from Helicobacter pylori. J Biol Chem 1992; 267: 10570-10575
13. Lupetti P, Heuser JE, Manetti R, Massari P, Lanzavecchia S, Bellon PL, Dallai R, Rappuoli R, Telford JL. Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin. J Cell Biol 1996; 133: 801-807
14. Nguyen VQ, Caprioli RM, Cover TL. Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin. Infect Immun 2001; 69: 543-546
15. Lanzavecchia S, Bellon PL, Lupetti P, Dallai R, Rappuoli R, Telford JL. Three-dimensional reconstruction of metal replicas of the Helicobacter pylori vacuolating cytotoxin. Struct Biol 1998; 121: 9-18
16. Cover TL, Hanson PI, Heuser JE. Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly. J Cell Biol 1997; 138: 759-769
17. Yahiro K, Niidome T, Kimura M, Hatakeyama T, Aoyagi H, Kurazono H, Imagawa K, Wada A, Moss J, Hirayama T. Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta. J Biol Chem 1999; 274: 36693-36699
18. McClain MS, Cao P, Cover TL. Amino-terminal hydrophobic region of Helicobacter pylori vacuolating cytotoxin (VacA) mediates transmembrane protein dimerization. Infect Immun 2001; 69: 1181-1184
19. Cover TL, Halter SA, Blaser MJ. Characterization of HeLa cell vacuoles induced by Helicobacter pylori broth culture supernatant. Hum Pathol 1992; 23: 1004-1010
20. Hopp TP, Woods KR. Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci U S A 1981; 78: 3824-3828
21. Scott JK, Smith GP. Searching for peptide ligands with an epitope library. Science 1990; 249: 386-390
22. Welling GW, Weijer WJ, van der Zee R, Welling-Wester S. Prediction of sequential antigenic regions in proteins. FEBS Lett 1985; 188: 215-218
23. Zhao S, Goodsell DS, Olson AJ. Analysis of a data set of paired uncomplexed protein structures: new metrics for side-chain flexibility and model evaluation. Proteins 2001; 43: 271-279
24. Kolibal SS, Brady C, Cohen SA. Definition of epitopes for monoclonal antibodies developed against purified sodium channel protein: implications for channel structure. J Membr Biol 1998; 165: 91-99
25. Thomson SA, Sherritt MA, Medveczky J, Elliott SL, Moss DJ, Fernando GJ, Brown LE, Suhrbier A. Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccination. J Immunol 1998; 160: 1717-1723
26. Mateo L, Gardner J, Chen Q, Schmidt C, Down M, Elliott SL, Pye SJ, Firat H, Lemonnier FA, Cebon J, Suhrbier A. An HLA-A2 polyepitope vaccine for melanoma immunotherapy. J Immunol 1999; 163: 4058-4063