Analysis of G-protein-coupled receptor kinase RGS homology domains

Methods in Enzymology

Volumn 390, Issue , 2004, Pages 295-310

  Day, Peter W ^a   Wedegaertner, Philip B ^a   Benovic, Jeffrey L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 4344579208     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(04)90019-5     Document Type: Chapter

References (21)

1. Biddlecome G.H., Berstein G., Ross E.M. Regulation of phospholipase C-β1 by Gq and m1 muscarinic cholinergic receptor: Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation. J. Biol. Chem. 271:1996;7999-8007
2. q11 by an RGS domain in the G protein-coupled receptor kinase, GRK2. J. Biol. Chem. 274:1999;34483-34492
3. Chen Z., Wells C.D., Sternweis P.C., Sprang S.R. Structure of the rgRGS domain of p115RhoGEF. Nature Struct Biol. 8:2001;805-809
4. Chidiac P., Gadd M.E., Hepler J.R. Measuring RGS protein interactions with Gqα Methods Enzymol. 344:2002;686-702
5. q family. Biochemistry. 42:2003;9176-9184
6. Hart M.J., Jiang X., Kozasa T., Roscoe W., Singer W.D., Gilman A.G., Sternweis P.C., Bollag G. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Gα13. Science. 280:1998;2112-2114
7. Hepler J.R., Berman D.M., Gilman A.G., Kozasa T. RGS4 and GAIP are GTPase-activating proteins for Gqα and block activation of phospholipase C β by γ-thio-GTP-Gqα Proc. Natl. Acad. Sci. USA. 94:1997;428-432
8. Heximer S.P., Lim H., Bernard J.L., Blumer K.J. Mechanisms governing subcellular localization and function of human RGS2. J. Biol. Chem. 276:2001;14195-14203
9. Kishida S., Yamamoto H., Ikeda S., Kishida M., Sakamoto I., Koyama S., Kikuchi A. Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin. J. Biol. Chem. 273:1998;10823-10826
10. Krupnick J.G., Benovic J.L. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu. Rev. Pharmacol. Toxicol. 38:1998;289-319
11. Lodowski D.T., Pitcher J.A., Capel W.D., Lefkowitz R.J., Tesmer J.J. Keeping G proteins at bay: A complex between G protein-coupled receptor kinase 2 and Gβγ Science. 300:2003;1256-1262
12. Longenecker K.L., Lewis M.E., Chikumi H., Gutkind J.S., Derewenda Z.S. Structure of the RGS-like domain from PDZ-RhoGEF: Linking heterotrimeric G protein-coupled signaling to Rho GTPases. Structure. 9:2001;559-569
13. Pitcher J.A., Freedman N.J., Lefkowitz R.J. G protein-coupled receptor kinases. Annu. Rev. Biochem. 67:1998;653-692
14. Pitcher J.A., Inglese J., Higgins J.B., Arriza J.L., Casey P.J., Kim C., Benovic J.L., Kwatra M.M., Caron M.G., Lefkowitz R.J. Role of βγ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors. Science. 257:1992;1264-1267
15. Pronin A.N., Loudon R.P., Benovic J.L. Characterization of G protein-coupled receptor kinases. Methods Enzymol. 343:2002;547-559
16. Ross E.M., Wilkie T.M. GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein signaling (RGS) and RGS-like proteins. Annu. Rev. Biochem. 69:2000;795-827
17. Sallese M., Mariggio S., D'Urbano E., Iacovelli L., De Blasi A. Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: Direct interaction of kinase N terminus with activated Gαq. Mol. Pharmacol. 57:2000;826-831
18. Siderovski D.P., Hessel A., Chung S., Mak T.W., Tyers M. A new family of regulators of G-protein-coupled receptors? Curr. Biol. 6:1996;211-212
19. Sterne-Marr R., Tesmer J.J., Day P.W., Stracquatanio R.P., Cilente J.A., O'Connor K.E., Pronin A.N., Benovic J.L., Wedegaertner P.B. GRK2:Gαq11 interaction: A novel surface on an RGS homology domain for binding Gα subunits. J. Biol. Chem. 278:2003;6050-6058
20. Usui H., Nishiyama M., Moroi K., Shibasaki T., Zhou J., Ishida J., Fukamizu A., Haga T., Sekiya S., Kimura S. RGS domain in the amino-terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling. Int. J. Mol. Med. 5:2000;335-340
21. Zhong H., Neubig R.R. Regulator of G protein signaling proteins: Novel multifunctional drug targets. J. Pharmacol. Exp. Ther. 297:2001;837-845