Synthesis and evaluation of novel bioactive composite starch/bioactive glass microparticles

Journal of Biomedical Materials Research - Part A

Volumn 70, Issue 3, 2004, Pages 442-449

  Silva, G A ^a,b   Costa, F J ^a   Coutinho, O P ^a   Radin, S ^b   Ducheyne, P ^b   Reis, R L ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bioactive; Bioactive glass; Biodegradable; Composites; Microparticles; Natural origin; Short term cytotoxicity; Starch

Indexed keywords

BODY FLUIDS; CELLS; COMPOSITE MATERIALS; ENCAPSULATION; GENES; PROTEINS; STARCH;

BIOACTIVE GLASS (BG); CHEMICAL CHARACTERIZATION; MICROPARTICLES; MORPHOGENETIC PROTEINS;

BIOMEDICAL ENGINEERING;

APATITE; BIOMATERIAL; BONE MORPHOGENETIC PROTEIN; CALCIUM PHOSPHATE; GLASS; NANOPARTICLE; POLYLACTIC ACID; STARCH;

ANIMAL CELL; ARTICLE; BIODEGRADATION; BODY FLUID; CHEMICAL ANALYSIS; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; EMULSION; ENCAPSULATION; EVALUATION; MORPHOLOGY; MOUSE; NONHUMAN; PARTICLE SIZE; POWDER; SIMULATION; SYNTHESIS;

EID: 4344577848     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.30099     Document Type: Article

References (24)

1. Hench L, Andersson O. Bioactive glasses. In: Hench L, Wilson J, editors. An introduction to bioceramics. Advanced series in bioceramics I. Singapore: World Scientific; 1993. p 41-62.
2. Ducheyne P. Bioceramics: material characteristics versus in vivo behavior. J Biomed Mater Res 1987;21(A2):219-236.
3. Gomes ME, Ribeiro AS, Malafaya PB, Reis RL, Cunha AM. A new approach based on injection moulding to produce biodegradable starch based polymeric scaffolds. Biomaterials 2001;22:883-889.
4. Reis RL, Cunha AM. Starch and starch based thermoplastics. Biological and biomimetic materials. In: Jurgen Buschow KH, Cahn RW, Flemings MC, Ilschner B, Kramer EJ, Mahajan S, editors. Encyclopedia of materials science and technology. Vol. 11. Amsterdam: Pergamon-Elsevier Science; 2001. p 8810-8816.
5. Boesel LF, Mano JF, Elvira C, San Román J, Reis RL. Hydrogels and hydrophilic partially degradable bone cements based on biodegradable blends incorporating starch. In: Chiellini E, editor. Biodegradable polymers and plastics. Dordrecht: Kluwer Academic; 2003. Forthcoming.
6. Malafaya PB, Elvira C, Gallardo A, San Román J, Reis RL. Porous starch-based drug delivery systems processed by a microwave treatment. J Biomater Sci Polym Ed 2001;12(11): 1227-1241.
7. Gomes ME, Godinho JS, Tchalamov D, Cunha AM, Reis RL. Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation, mechanical properties and biological response. Mater Sci Eng C 2002;20(1-2):19-26.
8. Reis RL, Cunha AM, Allan PS, Bevis MJ. Mechanical behaviour of injection moulded starch based polymers. J Polym Adv Tech 1996;7:784-790.
9. Sousa RA, Mano JF, Reis RL, Cunha AM, Bevis MJ. Mechanical performance of starch based bioactive composite biomaterials molded with preferred orientation for potential medical applications. Polym Eng Sci 2002;42(5):1032-1045.
10. Marques AP, Reis RL, Hunt JA. In vitro evaluation of the biocompatibility of novel starch based polymeric and composite material. Biomaterials 2001;21:1471-1478.
11. Mendes SC, Bovell YP, Reis RL, Cunha AM, de Bruijn JD, van Blitterswijk CA. Biocompatibility testing of novel starch-based materials with potential application in orthopaedic surgery. Biomaterials 2001;22:2057-2064.
12. El-Ghannam A, Ducheyne P, Shapiro IM. Formation of surface reaction products on bioactive glass and their effects on the expression of the osteoblastic phenotype and the deposition of mineralized extracellular matrix. Biomaterials 1997;18:295-303.
13. Lai W, Garino J, Ducheyne P. Silicon excretion from bioactive glass implanted in rabbit bone. Biomaterials 2002;23:213-217.
14. Scheppers E, De Clercq M, Ducheyne P, Kempeneers R. Bioactive glass particulate material as a filler for bone lesions. Oral Rehab 1991;18:439-452.
15. Ducheyne P. Stimulation of biological function with bioactive glass. Mater Res Bull 1998;23:43-49.
16. Silva GA, Dias ACP, Coutinho OP, Reis RL. Entrapment ability and release profile of corticosteroids using starch-based microparticles. 2004. In preparation.
17. Qiu QQ, Ducheyne P, Ayyaswamy PS. New bioactive, degradable composite microspheres as tissue engineering substrates. J Biomed Mater Res 2000;52:66-76.
18. Abe Y, Kokubo T, Yamamuro T. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J Mater Sci Mater Med 1990;1:233.
19. Yee HY. A simplified method for automated phosphorus analysis of serum and urine. Clin Chem 1968;14:898-902.
20. Zeltinger J, Sherwood JK, Graham DA, Mueller R, Griffith LG. Effect of pore size and void fraction on cellular adhesion, proliferation and matrix deposition. Tissue Eng 2001;7(5):557-572.
21. Slater TF, Sawyer B, Strauli U. Studies on succinate-tetrazolium reductase systems. III. Points of coupling of four different tetrazolium salts. Biochim Biophys Acta 1963;77:383-393.
22. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
23. Silva GA, Vaz CM, Coutinho OP, Cunha AM, Reis RL. In vitro degradation and cytocompatibility evaluation of novel soy and sodium caseinate-based membrane biomaterials. J Mater Sci Mater Med 2003;14:1055-1066.
24. Smith PK. Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85.