Detection of Oestrogen receptors (ER) α and β in conjunctiva, lacrimal gland, and tarsal plates

Eye

Volumn 18, Issue 7, 2004, Pages 729-733

  Spelsberg, H ^a   Klueppel, M ^a   Reinhard, T ^a   Glaeser, M ^b   Niederacher, D ^a   Beckmann, M W ^c   Sundmacher, R ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b LILLY DEUTSCHLAND GMBH   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Conjunctiva; Keratoconjunctivitis sicca; Lacrimal gland; Oestrogen receptor; Tarsal plate

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA;

ADULT; AGED; ARTICLE; CATARACT EXTRACTION; CLINICAL ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; EYELID RECONSTRUCTION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATOCONJUNCTIVITIS SICCA; LACRIMAL GLAND; MALE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAMPLE SIZE; TISSUE SECTION;

EID: 4344570970     PISSN: 0950222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.eye.6701314     Document Type: Article

References (19)

1. Sullivan DA, Sullivan BD, Evans JE, Schirra E. Yamagami H, Liu M et al. Androgen deficiency, meibomian gland dysfunction, and evaporative dry eye. Ann NY Acad Sci 2002; 966: 211-222.
2. Kramer P, Lubkin V, Potter W, Jacobs M, Labay G, Silverman P. Cyclic changes in conjunctival smears from menstruating females. Ophthalmology 1990; 97: 303-307.
3. Wenderlein M, Mattes S. Phänomen 'Trockenes Auge' und Ovarialfunktion. Studie an 700 Frauen prä- und postmenopausal. Zentralbl Gynakol 1996; 118: 643-649.
4. Schaumberg DA, Buring JE, Sullivan DA, Dana MR. Hormone replacement therapy and dry eye syndrome. JAMA 2001; 286: 2114-2119.
5. Sator MO, Joura EA, Golaszewski T, Gruber D, Frigo P, Metka M et al. Treatment of menopausal keratoconjunctivitis sicca with topical oestradiol. Br J Obstet Gynaecol 1998; 105: 100-102.
6. Pavao M, Traish AM. Estrogen receptor antibodies: specificity and utility in detection, localization and analyses of estrogen receptor a and β. Review article. Steroids 2001; 66: 1-16.
7. Wickham LA, Gao J, Toda I, Rocha EM, Ono M, Sullivan DA. Identification of androgen, estrogen and progesterone receptor mRNAs in the eye. Acta Ophthalmol Scand 2000; 78: 146-153.
8. Suzuki T, Kinoshita Y, Tachibana M, Matsushima Y, Kobayashi Y, Adachi W et al. Expression of sex steroid hormone receptors in human cornea. Curr Eye Res 2001; 22: 28-33.
9. Munaut C, Lambert V, Noël A, Frankenne F, Deprez M, Foidart JM et al. Presence of oestrogen receptor type β in human retina. Br J Ophthalmol 2001; 85: 877-882.
10. Esmaeli B, Harvey JT, Hewlett B. Immunohistochemical evidence for estrogen receptors in meibomian gland. Ophthalmology 2000; 107: 180-184.
11. Ogueta SB, Schwartz SD, Yamashita CK, Farber DB. Estrogen receptor in the human eye: influence of gender and age on gene expression. Invest Opthalmol Vis Sci 1999; 40: 1906-1911.
12. Gans LA, Lee SF, Lemp MA, Pepose JS. Estrogen and progesterone receptors and human conjunctiva. Am J Ophthalmol 1990; 109: 474-477.
13. Lemp MA, Chacko B. Diagnosis and treatment of tear deficiencies. In: Tasman W, Jaeger EA (eds). Clinical Ophthalmology, Vol. 4, Chapter 14. Lippincott-Raven: New York, 1991, pp 1-13.
14. Gläser M, Beckmann MW, Hanstein B, Floetotto T, Niederacher D. Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas. Horm Metab Res 2001; 33: 121-126.
15. Beckmann MW, Niederacher D, Massenkeil G, Tutschek B, Beckmann A, Schenko G et al. Expression analyses of epidermal growth factor receptor and Her-2/neu: no advantage of prediction of recurrence or survival in breast cancer patients. Oncology 1996; 53: 441-447.
16. Sullivan DA, Wickham LA, Rocha EM, Krenzer KL, Sullivan BD, Steagall R et al. Androgens and dry eye in Sjögren's syndrome. Ann NY Acad Sci 1999; 876: 312-324.
17. Suzuki T, Sullivan DA. Estrogen stimulation of cytokine gene expression in human corneal epithelial cells. Abstract ARVO 2002.
18. Worda C, Nepp J, Huber JC, Sator MC. Treatment of keratoconjunctivitis sicca with topical androgen. Maturitas 2001; 37: 209-212.
19. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 1998; 17: 584-589.