A small randomized phase III single-center trial on postoperative UFT administration in patients with completely resected non-small cell lung cancer

Anti-Cancer Drugs

Volumn 15, Issue 1, 2004, Pages 29-33

  Ueda, Hitoshi ^a,b   Sakada, Takashi ^a   Kuwahara, Motohisa ^a   Motohiro, Akira ^a  

^a FUKUOKA NATIONAL HOSPITAL   (Japan)

^b MATSUYAMA RED CROSS HOSPITAL   (Japan)

Author keywords

Adjuvant therapy; Non small cell lung cancer; Surgery; UFT

Indexed keywords

UFT;

ADULT; AGED; ANOREXIA; ARTICLE; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG WITHDRAWAL; FATIGUE; FEMALE; FOLLOW UP; HERPES ZOSTER; HUMAN; LIVER INJURY; LUNG NON SMALL CELL CANCER; MALE; NAUSEA; PATIENT COMPLIANCE; PHASE 3 CLINICAL TRIAL; POSTOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH ULCER; SURGICAL TECHNIQUE; SURVIVAL RATE; TREATMENT OUTCOME;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; JAPAN; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; POSTOPERATIVE CARE; PROSPECTIVE STUDIES; SURVIVAL RATE; TEGAFUR; TREATMENT OUTCOME; URACIL;

EID: 4344561704     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200401000-00005     Document Type: Article

References (17)

1. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics, 2003. CA Cancer J Clin 2003; 53:5-26.
2. Japanese Joint Committee of Lung Cancer Registry Lung Cancer in Japan. Analysis of Lung Cancer Registry for resected cases in 1994. Jap J Lung Cancer 2002; 42:555-566.
3. Non-small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trails. Br Med J 1995; 311:899-909.
4. Taniguchi T. UFT: biochemical modulation for 5-fluorouracil (5-FU). Clin Med J (Engl) 1997; 110:294-296.
5. Ota K, Taguchi T, Kimura K. Report on nationwide pooled data and cohort investigation in UFT phase II study. Cancer Chem Pharm 1988; 22:333-338.
6. Wada H, Hitomi S, Teramatsu T, the West Japan Study Group for Lung Cancer Surgery. Adjuvant chemotherapy after complete resection in non-small-cell Lung caner. J Clin Oncol 1996; 14:1048-1054.
7. Wada H, Tanaka F, Yanagihara K, Ariyasu T, Yokomise H, Inui K, et al. Time trends and survival after surgery for primary lung cancer during 1976-1990. J Thorac Cardiovasc Surg 1996; 112:349-355.
8. Bach PB, Cramer LD, Schrag D, Downey RJ, Gelfand SE, Gegg CB. The influence of hospital volume on survival after resection for lung cancer. N Engl J Med 2001; 345:181-188.
9. Endo C, Saito Y, Iwanami H, Tsushima T, Imai T, Kawamura M, et al. A randomized trial of postoperative UFT therapy in p stage I, II non-small cell lung cancer: North-east Japan Study Group for Lung Cancer Surgery. Lung Cancer 2003; 40:181-186.
10. Watanabe H, Yamamoto S, Naito T. Clinical results of oral UFT therapy under cooperative study. Jpn J Cancer Chemother 1980; 7:1588-1596.
11. Nishioka K, Nomura K, Hashimoto S, Matsumoto M, Yunoki K, Tomomatsu H, et al. Clinical effect of UFT on the advanced cancer with special reference to lung cancer. Jpn J Cancer Chemother 1981; 8:294-301.
12. Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002; 346:92-98.
13. Nakanishi H, Kobayashi K, Nishimura T, Inada K, Tsukamoto T, Tatematsu M. Chemosensitivity of micrometastasis and circulating tumor cells to uracil and tegafur as evaluated using LacZ gene-tagged Lewis lung carcinoma cell. Cancer Lett 1999; 142:31-41.
14. Uchida J, Sato K, Okabe H, Saito H, Nakano K, Fujioka A, et al. Experimental postoperative adjuvant chemotherapy by UFT using primary tumor amputation model. Int J Mol Med 2000; 5:357-362.
15. Ishikura H, Kondo K, Miyoshi T, Kinoshita H, Takahashi Y, Fujino H, et al. Suppression of mediastinal metastasis by uracil-tegafur or cis-diamminedichloroplatinum(II) using a lymphogenous metastatic model in a human lung cancer cell line. Clin Cancer Res 2001; 7:4202-4208.
16. Shibata J, Murakami K, Abe M, Hashimoto A, Utsugi T, Fukushima M, et al. Life prolonging effect of antitumor agents on postoperative adjuvant therapy in the lung spontaneous metastasis model in mice. Anticancer Res 1998; 18:1203-1209.
17. Yonekura K, Basaki Y, Chikahisa L, Okabe S, Hashimoto A, Miyadera K, et al. UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice. Clin Cancer Res 1999; 5:2185-2191.