Erythropoietin attenuates hydrogen peroxide-induced damage of hepatocytes

Turkish Journal of Gastroenterology

Volumn 18, Issue 4, 2007, Pages 239-244

  Yazihan, Nuray ^a   Ataoǧlu, Haluk ^a   Yener, Burcu ^a   Aydin, Cengiz ^b  

^a ANKARA UNIVERSITY   (Turkey)

^b Yuksek Ihtisas Heart Education and Research Hospital   (Turkey)

Author keywords

ATP dependent K channel; Caspase 3; Erythropoietin (EPO); Glibenclamide; Hepatocyte; Hydrogen peroxide (H2O2) toxicity; Lactate dehydrogenase (LDH)

Indexed keywords

CASPASE 3; ERYTHROPOIETIN; GLIBENCLAMIDE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; POTASSIUM CHANNEL;

APOPTOSIS; ARTICLE; ATTENUATION; CELL ASSAY; CELL COUNT; CELL PROLIFERATION; CELL PROTECTION; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; ENZYME RELEASE; HUMAN; HUMAN CELL; LIVER CELL; MITOCHONDRION; OXIDATIVE STRESS;

APOPTOSIS; CASPASE 3; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; ERYTHROPOIETIN; GLYBURIDE; HEPATOCYTES; HUMANS; HYDROGEN PEROXIDE; L-LACTATE DEHYDROGENASE; LIVER NEOPLASMS; OXIDATIVE STRESS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; TUMOR CELLS, CULTURED;

EID: 43349099248     PISSN: 13004948     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Jaeschke H, Gores GJ, Cederbaum AI, et al. Mechanisms of hepatotoxicity. Toxicol Sci 2002; 65(2): 166-76.
2. Yeldandi AV, Rao MS, Reddy JK. Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis. Mutat Res 2000; 448(2): 159-77.
3. Jaeschke H. Mechanisms of liver injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions. Am J Physiol Gastrointest Liver Physiol 2006; 290(6): G1083-8.
4. Schwabe RF, Brenner DA. Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006; 290(4): G583-9.
5. Ghezzi P, Brines M. Erythropoietin as an antiapoptotic, tissue-protective cytokine. Cell Death Differ 2004; 11 (Suppl 1): S37-44.
6. Fliser D, Bahlmann FH, Haller H. EPO: renoprotection beyond anemia correction. Pediatr Nephrol 2006; 21(12): 1785-9.
7. Wei L, Yu SP, Gottron F, et al. Potassium channel blockers attenuate hypoxia- and ischemia-induced neuronal death in vitro and in vivo. Stroke 2003; 34(5): 1281-6.
8. Chai Y, Niu L, Sun XL, et al. Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel. Biochem Biophys Res Commun 2006; 350(2): 307-14.
9. Hai S, Takemura S, Minamiyama Y, et al. Mitochondrial K(ATP) channel opener prevents ischemia-reperfusion injury in rat liver. Transplant Proc 2005; 37(1): 428-31.
10. Ates E, Yilmaz S, Ihtiyar E, et al. Preconditioning-like amelioration of erythropoietin against laparoscopy-induced oxidative injury. Surg Endosc 2006; 20(5): 815-9.
11. Joyeux-Faure M, Ramond A, Beguin PC, et al. Early pharmacological preconditioning by erythropoietin mediated by inducible NOS and mitochondrial ATP-dependent potassium channels in the rat heart. Fundam Clin Pharmacol 2006; 20(1): 51-6.
12. Cuzzocrea S, Di Paola R, Mazzon E, et al. Erythropoietin reduces the development of nonseptic shock induced by zymosan in mice. Crit Care Med. 2006; 34(4): 1168-77.
13. Peltenburg HG, Hermens WT, Willems GM, et al. Estimation of the fractional catabolic rate constants for the elimination of cytosolic liver enzymes from plasma. Hepatology 1989; 10(5): 833-9.
14. Liu D, Slevin JR, Lu C, et al. Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death. J Neurochem 2003; 86(4): 966-79.
15. Takashi E, Wang Y, Ashraf M. Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway. Circ Res 1999; 85(12): 1146-53.
16. Malhi H, Irani AN, Rajvanshi P, et al. KATP channels regulate mitogenically induced proliferation in primary rat hepatocytes and human liver cell lines. Implications for liver growth control and potential therapeutic targeting. J Biol Chem 2000; 275(34): 26050-7.
17. Huang Q, Bu S, Yu Y, et al. Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase. Endocrinology 2007; 148(1): 81-91.
18. Ahmad N, Wang Y, Haider KH, et al. Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning. Am J Physiol Heart Circ Physiol 2006; 290(6): H2402-8.
19. Hanlon PR, Fu P, Wright GL, et al. Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling. FASEB J 2005; 19(10): 1323-5.