The deadly toll of invasive methicillin-resistant Staphylococcus aureus infection in community hospitals

Clinical Infectious Diseases

Volumn 46, Issue 10, 2008, Pages 1568-1577

  Kaye, Keith S ^a,b,c   Anderson, Deverick J ^a,b   Choi, Yong ^a,b   Link, Katherine ^a,b   Thacker, Paul ^a,b   Sexton, Daniel J ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

^c Box 3152 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; CARBAPENEM; CEPHALOSPORIN; CIPROFLOXACIN; LINEZOLID; MACROLIDE; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULFAMETHOXAZOLE; VANCOMYCIN; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; BACTERIUM IDENTIFICATION; COHORT ANALYSIS; COMMUNITY HOSPITAL; CONTROLLED STUDY; FEMALE; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORTALITY; OUTCOME ASSESSMENT; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; SEPSIS; STAPHYLOCOCCUS INFECTION; SURGICAL INFECTION; TERTIARY HEALTH CARE; TREATMENT OUTCOME; AGED; COMPARATIVE STUDY; CROSS INFECTION; DRUG EFFECT; HOSPITAL; MICROBIOLOGY; MIDDLE AGED; PENICILLIN RESISTANCE; PROSPECTIVE STUDY; STAPHYLOCOCCUS AUREUS; TIME; UNITED STATES;

AGED; ANTI-BACTERIAL AGENTS; BACTEREMIA; COHORT STUDIES; CROSS INFECTION; FEMALE; HOSPITALS; HUMANS; MALE; METHICILLIN RESISTANCE; MIDDLE AGED; PROSPECTIVE STUDIES; SOUTHEASTERN UNITED STATES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; SURGICAL WOUND INFECTION; TIME FACTORS; TREATMENT OUTCOME;

EID: 43249118667     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/587673     Document Type: Article

References (18)

1. Fast facts on US hospitals. Vol. 2007. Washington, DC: American Hospital Association, 2007.
2. Accreditation Council for Graduate Medical Education. 2004-2005 Annual report. Vol. 2007. Chicago, IL: Accreditation Council for Graduate Medical Education, 2005.
3. Cosgrove SE, Carmeli Y. The impact of antimicrobial resistance on health and economic outcomes. Clin Infect Dis 2003; 36:1433-7.
4. Fowler VG Jr, Justice A, Moore C, et al. Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia. Clin Infect Dis 2005; 40:695-703.
5. King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med 2006; 144:309-17.
6. Cosgrove SE, Qi Y, Kaye KS, Harbarth S, Karchmer AW, Carmeli Y. The impact of methicillin resistance in Staphylococcus aureus bacter emia on patient outcomes: mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol 2005; 26:166-74.
7. Kaye KS, Sloane R, Sexton DJ, Schmader KA. Risk factors for surgical site infections in older people. J Am Geriatr Soc 2006; 54:391-6.
8. Kaye KS, Schmit K, Pieper C, et al. The effect of increasing age on the risk of surgical site infection. J Infect Dis 2005; 191:1056-62.
9. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16:128-40.
10. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40:373-83.
11. McCabe WR, Jackson GG. Gram-negative bacteremia. Arch Intern Med 1962; 110:847-55.
12. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged: the index of ADL - a standardized measure of biological and psychosocial function. JAMA 1963; 185:914-9.
13. Friedman ND, Kaye KS, Stout JE, et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002; 137:791-7.
14. Social Security Death Index. Available at: http://ssdi.rootsweb.com/. Accessed 15 December 2007.
15. Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, Carmeli Y. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 2003; 36:53-9.
16. Engemann JJ, Carmeli Y, Cosgrove SE, et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis 2003; 36:592-8.
17. Saiman L, O'Keefe M, Graham PL 3rd, et al. Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women. Clin Infect Dis 2003; 37:1313-9.
18. Institute for Healthcare Improvement Campaign Web page. Available at: http://www.ihi.org/IHI/Programs/Campaign/. Accessed 15 December 2007.